May 7, 2021

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Nitric Oxide Donors

Nitric Oxide Donors
Author : Peng George Wang,Tingwei Bill Cai,Naoyuki Taniguchi
Publisher : John Wiley & Sons
Release Date : 2005-08-16
Category : Science
Total pages :407
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Nitric oxide is a highly potent regulatory molecule with great pharmaceutical potential. This handbook fills a real gap in combining the chemistry of nitric oxide releasing substances with their practical applications in biology and drug design. It covers all classes of nitric oxide donors, from organic nitrates to nitroso compounds, guanidines and metal-NO complexes. In addition to a detailed treatment of the chemistry of NO donors, numerous examples of successful diagnostic and pharmacological applications are discussed, as well as further therapeutic targets for these substances.

Nitric Oxide Donors

Nitric Oxide Donors
Author : Amedea Seabra
Publisher : Academic Press
Release Date : 2017-03-17
Category : Medical
Total pages :364
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Nitric Oxide Donors: Biomedical Applications and Perspectives presents the current state of art, challenges and innovations in the design of therapeutics nitric oxide donors with great impact in several aspects of human physiology and pathophysiology. Although considerable innovative progress has been achieved using Nitric Oxide donors in biomedical applications, certain drawbacks still need to be overcome to successfully translate these research innovations into clinical applications. This book encompasses several topics on nitric oxide such as its sources and biological properties; its performance in the cardiovascular and neurologic systems, in the human skin and its application in the treatment of neglected diseases, neurodegenerative disorders, and cancer. Additionally, it covers its role in inflammation and immunity, penile erection function, photodynamic therapy, antimicrobial activities. It also discusses the future of nitric oxide donors in combination with other therapeutic drugs, in implantable sensors, and nitric oxide releasing hydrogels and medical devices for topical applications. The book is a valuable source for researchers on different areas of biomedical field who are interested in the improvements that these molecules can make in the treatment of several conditions. Provides background information about biology and chemistry of nitric oxide Discusses the state-of-the-art in the design of nitric oxide releasing nanomaterials for biomedical applications Covers the usage of nitric oxide donors in the treatment of several conditions, such as cancer, human skin, cardiovascular system, and immunity Discusses the future of nitric oxide donors and their FDA approval

Role of Free Radicals in the Bioactivation of Nitric Oxide Donors

Role of Free Radicals in the Bioactivation of Nitric Oxide Donors
Author : Samir Lutf M. Y. Aleryani
Publisher : Unknown
Release Date : 1999
Category : Biotransformation (Metabolism)
Total pages :226
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Nitric Oxide (Donor/Induced) in Chemosensitization

Nitric Oxide (Donor/Induced) in Chemosensitization
Author : Benjamin Bonavida
Publisher : Academic Press
Release Date : 2017-06-28
Category : Medical
Total pages :248
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Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy. Brings updated information as reviewed by experts in the field Presents expert analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches that can be used in reader investigations

Antiinflammatory and Antithrombotic Effects of Nitric Oxide Donors

Antiinflammatory and Antithrombotic Effects of Nitric Oxide Donors
Author : Alessandra Meneguzzi
Publisher : Unknown
Release Date : 2005
Category :
Total pages :93
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Photoactive Nitric Oxide Donors

Photoactive Nitric Oxide Donors
Author : Genevieve M. Halpenny
Publisher : Unknown
Release Date : 2011
Category :
Total pages :450
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Cumulated Index Medicus

Cumulated Index Medicus
Author : Anonim
Publisher : Unknown
Release Date : 1991
Category : Medicine
Total pages :129
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Synthesis and Characterization of Dendrimer-based Nitric ...

Synthesis and Characterization of Dendrimer-based Nitric ...
Author : Anonim
Publisher : Unknown
Release Date : 2021
Category :
Total pages :129
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Index Medicus

Index Medicus
Author : Anonim
Publisher : Unknown
Release Date : 2004
Category : Medicine
Total pages :129
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The Biology of Nitric Oxide

The Biology of Nitric Oxide
Author : Salvador Moncada
Publisher : Unknown
Release Date : 1992
Category : Cellular signal transduction
Total pages :397
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Methods in Nitric Oxide Research

Methods in Nitric Oxide Research
Author : Martin Feelisch,Jonathan Stamler
Publisher : John Wiley & Sons Incorporated
Release Date : 1996-06-04
Category : Medical
Total pages :712
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This handbook describes methods for the measurement and investigation of nitric oxide. The topics discussed include the metabolism of substrates and cofactors, the detection of nitrogen oxides, the detection of nitrogen oxide synthase activity, and the detection of adducts and reaction products.

Nitric Oxide, Part A: Sources and Detection of NO; NO Synthase

Nitric Oxide, Part A: Sources and Detection of NO; NO Synthase
Author : Lester Packer,Enrique Cadenas,Melvin I. Simon,Helmut Sies
Publisher : Academic Press
Release Date : 1996
Category : Science
Total pages :555
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Nitric oxide, recently named"Molecule of the Year"by the journal Science, impinges on a wide range of fields in biological research, particularly in the areas of biomedicine and cell and organismal biology, as well as in fundamental chemistry. This volume and its companion Volume 269 highlight the most current and up-to-date methods used to research the physiology and toxicity of nitric oxide in cellular and organismal systems. It will be a valuable resourcefor the experienced researcher as well as for those newly entering the field. Generation, detection, and characterization of biological and chemical sources of nitric oxide Biochemistry and molecular biology of enzymes and proteins associated with nitric oxide metabolism

Development of Nitric Oxide-releasing Polymers with Improved Blood Compatibility

Development of Nitric Oxide-releasing Polymers with Improved Blood Compatibility
Author : Huiping Zhang
Publisher : Unknown
Release Date : 2002
Category :
Total pages :129
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Recurrent Administration of the Nitric Oxide Donor, Isosorbide Dinitrate, Induces a Persistent Cephalic Cutaneous Hypersensitivity: A Model for Migraine Progression

Recurrent Administration of the Nitric Oxide Donor, Isosorbide Dinitrate, Induces a Persistent Cephalic Cutaneous Hypersensitivity: A Model for Migraine Progression
Author : Anonim
Publisher : Unknown
Release Date : 2021
Category :
Total pages :129
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Background A subgroup of migraineurs experience an increase in attack frequency leading to chronic migraine. Methods We assessed in rats the roles of dose and repeat administration of systemic isosorbide dinitrate (ISDN), a nitric oxide donor, on the occurrence and development of cephalic/face and extracephalic/hindpaw mechanical allodynia as a surrogate of migraine pain, and the effect of acute systemic sumatriptan and olcegepant and chronic systemic propranolol on these behavioral changes. Results A single high (H-ISDN) but not low (L-ISDN) dose of ISDN induces a reversible cephalic and extracephalic mechanical allodynia. However, with repeat administration, L-ISDN produces reversible cephalic but never extracephalic allodynia, whereas H-ISDN induces cephalic and extracephalic allodynia that are both potentiated. H-ISDN-induced cephalic allodynia thus gains persistency. Sumatriptan and olcegepant block single H-ISDN-induced behavioral changes, but only olcegepant reduces these acute changes when potentiated by repeat administration. Neither sumatriptan nor olcegepant prevent chronic cephalic hypersensitivity. Conversely, propranolol blocks repeat H-ISDN-induced chronic, but not acute, behavioral changes. Conclusions Repeated ISDN administration appears to be a naturalistic rat model for migraine progression, suitable for screening acute and preventive migraine therapies. It suggests frequent and severe migraine attacks associated with allodynia may be a risk factor for disease progression.

Studies on the Contribution of Oxygen and Metals Towards Nitric Oxide-mediated Cytotoxicity

Studies on the Contribution of Oxygen and Metals Towards Nitric Oxide-mediated Cytotoxicity
Author : Kenneth Teh-Ling Chiang
Publisher : Unknown
Release Date : 2000
Category :
Total pages :428
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