December 2, 2020

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Nitrosation Reactions and the Chemistry of Nitric Oxide

Nitrosation Reactions and the Chemistry of Nitric Oxide
Author : D.L.H. Williams
Publisher : Elsevier
Release Date : 2004-12-16
Category : Science
Total pages :280
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Since 1988, there has been much literature published on the chemistry of nitric oxide, particularly in the field of S-nitrosation and the chemistry of S-nitroso compounds. Written by a chemist for the chemistry community, this book provides an update of the chemistry of nitrosation reactions, dealing with both the synthetic and mechanistic aspects of these reactions. It also looks at the chemistry of nitric oxide in relation to the amazing biological properties of this simple diatomic molecule, which were unknown until around 1990. * Provides an update on previously published literature on nitric oxide chemistry * Contains chapters on reagents for nitrosation, nitrosation at nitrogen, aliphatic and aromatic carbon, oxygen, sulfur and metal centres * Looks at hot research topics such as synthesis, properties and reactions of s-nitrosothiols

NO More Heart Disease

NO More Heart Disease
Author : Louis Ignarro
Publisher : St. Martin's Press
Release Date : 2006-01-24
Category : Health & Fitness
Total pages :272
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Dr. Louis Ignarro discovered "the atom" of cardiovascular health--a tiny molecule called Nitric Oxide. NO, as it is known by chemists, is a signaling molecule produced by the body, and is a vasodilator that helps control blood flow to every part of the body. Dr. Ignarro's findings led to the development of Viagra. Nitric Oxide has a beneficial effect on the cardiovascular system as well. NO relaxes and enlarges the blood vessels, prevents blood clots that trigger strokes and heart attacks, and regulates blood pressure and the accumulation of plaque in the blood vessels. Dr. Ignarro's current research indicates that Nitric Oxide may help lower cholesterol by facilitating the actions of statin drugs like Lipitor. The goal of the regimen presented in NO More Heart Disease is to age proof the cardiovascular system, keeping the vascular network clean and elastic through enhanced NO productivity. The plan is easy-to-follow without extreme lifestyle adjustments, involving taking supplements to stimulate Nitric Oxide production, incorporating NO friendly food into the diet, and a moderate exercise program.

Nitric Oxide

Nitric Oxide
Author : Louis J. Ignarro
Publisher : Academic Press
Release Date : 2000-09-13
Category : Science
Total pages :1017
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Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas that is produced by one cell and which penetrates through membranes and regulates the function of another cell represents an entirely new principle for signaling in biological systems. NO is a signal molecule of key importance for the cardiovascular system acting as a regulator of blood pressure and as a gatekeeper of blood flow to different organs. NO also exerts a series of other functions, such as acting a signal molecule in the nervous system and as a weapon against infections. NO is present in most living creatures and made by many different types of cells. NO research has led to new treatments for treating heart as well as lung diseases, shock, and impotence. Scientists are currently testing whether NO can be used to stop the growth of cancerous tumors, since the gas can induce programmed cell death, apoptosis. This book is the first comprehensive text on nitric oxide to cover all aspects--basic biology, chemistry, pathobiology, effects on various disease states, and therapeutic implications. Edited by Nobel Laureate Louis J. Ignarro, editor of the Academic Press journal, Nitric Oxide Authored by world experts on nitric oxide Includes an overview of basic principles of biology and chemical biology Covers principles of pathobiology, including the nervous system, cardiovascular function, pulmonary function, and immune defense

Nitric Oxide

Nitric Oxide
Author : Lester Packer
Publisher : Gulf Professional Publishing
Release Date : 1996
Category : Nitric oxide
Total pages :528
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Nitric Oxide Protocols

Nitric Oxide Protocols
Author : Aviv Hassid
Publisher : Springer Science & Business Media
Release Date : 2004
Category : Science
Total pages :246
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Carrying on the high standards of the much-praised first edition of Nitric Oxide Protocols, Aviv Hassid has brought together a panel of expert researchers and clinician scientists to describe in step-by-step detail the latest methodologies for the measurement of nitric oxide--and the enzyme that produces it-in biological tissues and fluids. The authors take advantage of the latest methodologies for the quantitation of biological fluids and tissues, including capillary electrophoresis, microcoaxial electrodes, in vivo measurement of nitric oxide in exhaled air, confocal microscopy, gas chromatography, in situ hybridization, and real-time polymerase chain reaction. Chapters on the measurement of the novel products of nitric oxide, such as nitrated proteins, S-nitrosylated proteins, and dioxygen-dependent NO metabolism, are also included. Additional chapters address the expression of nitric oxide synthase via the use of viral vectors in gene therapy for erectile dysfunction and cancer, as well as in retrovirus, adenovirus, or adenoassociated virus-mediated expression of nitric oxide synthase in vivo. The protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. State-of-the-art and highly practical, Nitric Oxide Protocols, 2nd ed., offers investigators and clinican/scientists a gold-standard collection of readily reproducible analytical techniques for measuring levels of nitric oxide and determining its manifold functions and effects.

Nitric Oxide in the Eye

Nitric Oxide in the Eye
Author : A. Akaike
Publisher : Springer Science & Business Media
Release Date : 2000-08
Category : Medical
Total pages :184
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Nitric oxide (NO) is a simple gas with free radical properties. No one would have imagined a role for such a simple substance in the human body. In 1998, R. E Furchgott, E Murad, and L. J. Ignarro received the Nobel prize for their work on NO. Interestingly, Alfred B. Nobel, who invented dynamite by combining nitro glycerin with other substances, took nitroglycerin for his chest pain without realizing that NO mediates its action. Now, in addition to its vasodilating action, NO is known to possess many fundamental functions that include neurotrans mission, blood pressure control, blood clotting, and immune responses. These diverse functions, conversely, imply that the simple NO molecule may unite neuroscience, physiology, and immunology and may change our understanding of how cells communicate and defend themselves. In this context, the Inter national Symposium, Nitric Oxide and Free Radicals, was organized to address current thinking about the widespread distribution and variety of functions of NO in the eye. The symposium was held in Kyoto, Japan, September 28-29 as a Satellite Symposium of the XII International Congress of Eye Research, 1996. The Symposium was the first international gathering of leading scientists and ophthalmologists meeting to present and discuss their most recent results in a specialized area of research, specifically concerning the eye.

Nitric Oxide

Nitric Oxide
Author : Louis J. Ignarro,Bruce Freeman
Publisher : Academic Press
Release Date : 2017-08-03
Category : Science
Total pages :434
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Nitric Oxide: Biology and Pathobiology, Third Edition, provides information on nitric oxide, a signaling molecule of key importance for the cardiovascular system that regulates blood pressure and blood flow to different organs. With recent links to the role of nitric oxide in the expression of healthy benefits of controlled diet and aerobic exercise, and the reactions of nitric oxide that can impact cell signaling, this book provides a comprehensive resource during a time when increased research attention is being paid across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology. Includes perspectives from Jack Lancaster on the discovery of EDRF and nitric oxide Provides detailed coverage of the new gaseous signaling agents Features expanded coverage on the principles of biology, including nitric oxide synthases, nitrite and nitrate biology and pathobiology, and signaling mechanisms Incorporates expanded pathobiology coverage, including nitric oxide and cardiovascular function, obesity, diabetes, and erectile function/dysfunction

Nitric Oxide

Nitric Oxide
Author : Anonim
Publisher : Elsevier
Release Date : 2002-12-09
Category : Science
Total pages :514
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The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Presents information on nitrosothiols and nitric oxide in cell signaling Details nitric oxide and mitochondrial functions Explains nitric oxide synthases

On the Determination of Nitric Acid as Nitric Oxide

On the Determination of Nitric Acid as Nitric Oxide
Author : Robert Warington
Publisher : Unknown
Release Date : 1880
Category : Nitric acid
Total pages :15
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Food, Nutrition, and the Nitric Oxide Pathway

Food, Nutrition, and the Nitric Oxide Pathway
Author : Nathan S. Bryan
Publisher : DEStech Publications, Inc
Release Date : 2010
Category : Medical
Total pages :218
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This book provides a scientific analysis of the effects of foods and nutrients on the NO pathway in humans. Contributors to the book clarify novel chemical and biochemical connections between dietary intake and nitric oxide, particularly in cases of NO deficiency. In this context, the book addresses how specific foods can restore nitric oxide production and bioactivity—without medical interventions. A variety of evidential data is presented showing how NO-rich dietary elements are implicated in disease prevention and modulation. The book offers new knowledge for food technologists, food manufacturers, nutrition researchers, and healthcare practitioners. From the Foreword by Louis J. Ignarro, Nobel Laureate in Physiology/Medicine "The body of work contained in this volume, linking NO to food and nutrition, may have revolutionary implications in terms of developing strategies to combat heart disease and many other contemporary diseases associated with NO deficiency. Proving that a natural and inexpensive regimen of foods rich in nitric oxide activity does restore NO homeostasis can have profound effects on human health…The research presented in this text provides an important expansion of NO work…(and) Dr. Nathan Bryan, the editor…is to be congratulated for…communicating new knowledge and assembling the world's experts in their fields."

Nitric Oxide Protocols

Nitric Oxide Protocols
Author : Michael A. Titheradge
Publisher : Springer Science & Business Media
Release Date : 1998
Category : Science
Total pages :324
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Michael Titheradge provides both the experienced researcher and the newcomer with time-tested techniques to cover all aspects of NO synthase and metabolism. Topics range from the cloning and expression of the different isoforms of NO synthase to the role of NO in DNA damage and apoptosis and include indirect and direct measurements of NO production, measurement on NO synthase mRNA both in situ and in vitro, and Western blotting and immunohistochemical localization of different isoforms of NO synthase. A variety of alternative techniques are described to enable researchers to set up an assay using either the simplest equipment or the most expensive EPR machines.

The Role of Nitric Oxide in Heart Failure

The Role of Nitric Oxide in Heart Failure
Author : Bodh I. Jugdutt
Publisher : Springer Science & Business Media
Release Date : 2007-05-08
Category : Medical
Total pages :252
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Research on nitric oxide (NO) is a very hot topic since 1998, when three prominent researchers were recognized by Nobel prize awards. Addresses clinically pertinent issues related to nitric oxide in the pathophysiology and therapeutics of heart failure. Chapters written by basic scientists and clinicians to emphasize translation character of research in nitric oxide. An excellent reference source for researchers, practitioners and students.

Functional Neuroanatomy of the Nitric Oxide System

Functional Neuroanatomy of the Nitric Oxide System
Author : H.W.M. Steinbusch,J. de Vente,S.R. Vincent
Publisher : Elsevier
Release Date : 2000-06-30
Category : Psychology
Total pages :472
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This volume of the Handbook of Neuroanatomy is concerned with nitric oxide synthase. In this volume different research areas are presented together, which adds up to the first major review volume on the localization of nitric oxide synthase in the nervous system. The subjects range from developmental aspects in vertebrates to a functional neuroanatomy of the nervous system in vertebrates. This presentation gives an impressive look on the overwhelming presence of NOS in animal organism and the significance of NO - cGMP signaling. By clearly stating the limitations of our present knowledge the book is also a stimulant for further research. This book presents for the first time an overview of NOS and NO-cGMP signaling in the retina and urogenital system. In addition the effects if injuries on the expression of NOS are summarized in a number of models, which has not been done before. The frame of the book is a classical neuroanatomic description of the localization of NOS. Several authors give detailed advice to prevent pitfalls which may occur when different methods to locate NOS are used. In addition, several chapters detail the target structures for NO while describing the localization of NOS at the same time. All these points together make this volume very timely, i.e. overviewing a decade of NO research.

Nitric Oxide in Plants

Nitric Oxide in Plants
Author : Y.Y. Leshem
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Science
Total pages :154
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This book - the first published on this topic in plants - presents the reader with an overview of recent research on nitric oxide (NO) in plants, which, in view of its empirical interest and its growth regulatory potential, is in the forefront of scientific endeavor in plant science. Subject matter is divided into two parts: Part 1 deals with NO and peroxynitrite biochemistry and regulative mechanisms as presently known in the Plant Kingdom and outlines some of the problems still awaiting clarification. Emphasis is placed on ethylene emission regulation, postharvest control, plant phytopathology and environmental stress tolerance. A further topic is plant NO, like Viagra, related to cyclic nucleotide turnover. Part 2 deals with environmental aspects of NO as an atmospheric pollutant and discusses endogenous means which plants at times employ to cope with this particular type of stress, and how their coping mechanisms may be harnessed for purposes of depollution and augmentation of nitrogen fertilization. The text, accompanied by a wealth of illustrations and annotated references, is intended for lecturers, advanced students and research scientists at universities and research institutes dealing with plant sciences and agriculture, as well as for environmental researchers.

Methods in Nitric Oxide Research

Methods in Nitric Oxide Research
Author : Martin Feelisch,Jonathan Stamler
Publisher : John Wiley & Sons Incorporated
Release Date : 1996-06-04
Category : Medical
Total pages :712
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This handbook describes methods for the measurement and investigation of nitric oxide. The topics discussed include the metabolism of substrates and cofactors, the detection of nitrogen oxides, the detection of nitrogen oxide synthase activity, and the detection of adducts and reaction products.