November 28, 2020

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NMR Metabolomics in Cancer Research

NMR Metabolomics in Cancer Research
Author : Miroslava Čuperlović-Culf
Publisher : Elsevier
Release Date : 2012-12-17
Category : Medical
Total pages :446
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The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field. Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics Current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications Information about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

NMR-Based Metabolomics

NMR-Based Metabolomics
Author : G. A. Nagana Gowda,Daniel Raftery
Publisher : Humana
Release Date : 2020-08-29
Category : Science
Total pages :489
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This book provides broad coverage of nuclear magnetic resonance (NMR) spectroscopy-based methods and applications for the analysis of metabolites in a wide range of biological samples, from biofluids, cells, animal models, human, to plants and foods. The applications range from mechanistic understanding, biomarker discovery, environmental studies, and drug discovery to nutrition, while NMR methods include global, targeted, and isotope tracer-based techniques. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, NMR-Based Metabolomics: Methods and Protocols serves as a wealth of information for beginners as well as advanced practitioners and also as stepping stones for further advances in the field of metabolomics.

Methodologies for Metabolomics

Methodologies for Metabolomics
Author : Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers
Publisher : Cambridge University Press
Release Date : 2013-01-21
Category : Medical
Total pages :129
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Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.

Lung Cancer

Lung Cancer
Author : Alba Fabiola Costa Torres
Publisher : BoD – Books on Demand
Release Date : 2018-10-31
Category : Medical
Total pages :204
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Among the deadliest type of cancers, lung cancer faces several challenges in diagnosis and treatment: late diagnosis and misdiagnosis, inadequate tumor sampling, and resistance development to current therapies, among others. Together with advances in the understanding of molecular features, factors, and mechanisms involved in initiation and tumor progression, important improvements have occurred in diagnostics and therapeutics in the shape of advances in molecular genotyping, procedures for sampling, new potential, and less invasive sources of samples for the diagnosis and development of new targeted therapies. The aim of this book is to provide an exciting read on strategies in the diagnosis and therapy of lung cancer.

Cancer Metabolomics 2018

Cancer Metabolomics 2018
Author : Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto
Publisher : MDPI
Release Date : 2019-09-03
Category : Medical
Total pages :184
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The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.

Proteomic and Metabolomic Approaches to Biomarker Discovery

Proteomic and Metabolomic Approaches to Biomarker Discovery
Author : Haleem J. Issaq,Timothy D. Veenstra
Publisher : Academic Press
Release Date : 2019-10-24
Category : Science
Total pages :504
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Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

An Omics Perspective on Cancer Research

An Omics Perspective on Cancer Research
Author : William C.S. Cho
Publisher : Springer Science & Business Media
Release Date : 2010-04-07
Category : Medical
Total pages :269
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Omics is an emerging and exciting area in the field of science and medicine. Numerous promising developments have been elucidated using omics (including genomics, transcriptomics, epigenomics, proteomics, metabolomics, interactomics, cytomics and bioinformatics) in cancer research. The development of high-throughput technologies that permit the solution of deciphering cancer from higher dimensionality will provide a knowledge base which changes the face of cancer understanding and therapeutics. This is the first book to provide such a comprehensive coverage of a rapidly evolving area written by leading experts in the field of omics. It complies and details cutting-edge cancer research that covers the broad advances in the field and its application from cancer-associated gene discovery to drug target validation. It also highlights the potential of using integration approach for cancer research. This unique and timely book provides a thorough overview of developing omics, which will appeal to anyone involved in cancer research. It will be a useful reference book for graduate students of different subjects (medicine, biology, engineering, etc) and senior scientists interested in the fascinating area of advanced technologies in cancer research. Readership: This is a precious book for all types of readers – cancer researchers, oncologists, pathologists, biologists, clinical chemists, pharmacologists, pharmaceutical specialists, biostatisticians, and bioinformaticists who want to expand their knowledge in cancer research.

The Handbook of Metabonomics and Metabolomics

The Handbook of Metabonomics and Metabolomics
Author : John C. Lindon,Jeremy K. Nicholson,Elaine Holmes
Publisher : Elsevier
Release Date : 2011-08-11
Category : Science
Total pages :572
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Molecular biology operates at three levels – genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields of metabonomics and metabolomics. It covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications. * comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies * aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification * covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.

Applications of NMR Spectroscopy:

Applications of NMR Spectroscopy:
Author : Atta-ur-Rahman,M. Iqbal Choudhary
Publisher : Elsevier
Release Date : 2015-12-11
Category : Science
Total pages :232
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Applications of NMR Spectroscopy, Volume 1, originally published by Bentham and now distributed by Elsevier, presents the latest developments in the field of NMR spectroscopy, including the analysis of edible oils and lipid content in foods, the role of NMR spectroscopy in the human metabolomics and the diagnosis of autism-related disorders, protein-protein interactions, and NMR spectroscopy of chiral molecules. The fully illustrated chapters contain comprehensive references to the recent literature. The applications presented cover a wide range of the field, such as drug development, medical imaging and diagnostics, food science, mining, petrochemical, process control, materials science, and chemical engineering, making this resource a multi-disciplinary reference with broad applications. The content is ideal for readers who are seeking reviews and updates, as it consolidates scientific articles of a diverse nature into a single volume. Sections are organized based on disciplines, such as food science and medical diagnostics. Each chapter is written by eminent experts in the field. Consolidates the latest developments in NMR spectroscopy into a single volume Authored and edited by world-leading experts in spectroscopy Features comprehensive references to the most recent related literature More than 75 illustrations aid in the retention of key concepts

Principles of Clinical Cancer Research

Principles of Clinical Cancer Research
Author : Loren K. Mell, MD,Phuoc T. Tran, MD, PhD,James B. Yu, MD, MHS,Qiang (Ed) Zhang, PhD
Publisher : Springer Publishing Company
Release Date : 2018-11-28
Category : Medical
Total pages :576
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Principles of Clinical Cancer Research provides comprehensive coverage of the fundamentals of clinical cancer research, including the full spectrum of methodologies used in the field. For those involved in research or considering research careers, this book offers a mix of practical advice and analytical tools for effective training in theoretical principles as well as specific, usable teaching examples. The clinical oncologist or trainee will find a high-yield, practical guide to the interpretation of the oncology literature and the application of data to real-world settings. Valuable for both researchers and clinicians who wish to sharpen their skills, this book contains all of the cornerstones and explanations needed to produce and recognize quality clinical science in oncology. Written from the physician-scientist’s perspective, the book lays a strong foundation in preclinical sciences that is highly relevant to careers in translational oncology research along with coverage of population and outcomes research and clinical trials. It brings together fundamental principles in oncology with the statistical concepts one needs to know to design and interpret studies successfully. With each chapter including perspectives of both clinicians and scientists or biostatisticians, Principles of Clinical Cancer Research provides balanced, instructive, and high-quality topic overviews and applications that are accessible and thorough for anyone in the field. KEY FEATURES: Gives real-world examples and rationales behind which research methods to use when and why Includes numerous tables featuring key statistical methods and programming commands used in everyday clinical research Contains illustrative practical examples and figures in each chapter to help the reader master concepts Provides tips and pointers for structuring a career, avoiding pitfalls, and achieving success in the field of clinical cancer research Access to fully downloadable eBook

Metabolomics: From Fundamentals to Clinical Applications

Metabolomics: From Fundamentals to Clinical Applications
Author : Alessandra Sussulini
Publisher : Springer
Release Date : 2017-01-28
Category : Science
Total pages :350
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This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.

Tumor Microenvironment

Tumor Microenvironment
Author : Jacinta Serpa
Publisher : Springer Nature
Release Date : 2020-03-04
Category : Medical
Total pages :443
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The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.

NMR-based Metabolomics

NMR-based Metabolomics
Author : Hector C Keun
Publisher : Royal Society of Chemistry
Release Date : 2018-01-17
Category : Science
Total pages :368
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This book describes the state of the art in the application of NMR spectroscopy to metabolomics and will be a key title for researchers and practitioners.

Metabolomics and Systems Biology in Human Health and Medicine

Metabolomics and Systems Biology in Human Health and Medicine
Author : Oliver A.H. Jones
Publisher : CABI
Release Date : 2014-10-24
Category : Science
Total pages :206
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The metabolomics and systems biology approach to research can be applied to many disciplines. This book provides a solid introduction to medical metabolomics and systems biology, and demonstrates how they have been applied to studies in medicine and human health, including nutrition and pathogenic microorganisms. Following core themes of diagnosis, pathology and aetiology of disease, this book provides a reference for health care professionals interested in how to use metabolomics for medical research.

Cancer Research

Cancer Research
Author : Anonim
Publisher : Unknown
Release Date : 2007-03
Category : Cancer
Total pages :129
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