November 27, 2020

Download Ebook Free Novel Approaches And Strategies For Biologics, Vaccines And Cancer Therapies

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies
Author : Manmohan Singh,Maya Salnikova
Publisher : Academic Press
Release Date : 2014-12-30
Category : Medical
Total pages :520
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Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Drug Delivery Systems

Drug Delivery Systems
Author : Anonim
Publisher : Academic Press
Release Date : 2019-10-23
Category : Medical
Total pages :792
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Drug Delivery Systems examines the current state of the field within pharmaceutical science and concisely explains the history of drug delivery systems, including key developments. The book translates the physicochemical properties of drugs into drug delivery systems administered via various routes, such as oral, parenteral, transdermal and inhalational. Regulatory and product development topics are also explored. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of drug delivery systems within the pharmaceutical sciences industry and research, as well as in chemical engineering. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists. This book provides a comprehensive examination that is suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnologies, and related industries. Provides up-to-date information on how to translate the physicochemical properties of drugs into drug delivery systems Explores how drugs are administered via various routes, such as oral, parenteral, transdermal and inhalational Contains extensive references and further reading for course and self-study

Drying Technologies for Biotechnology and Pharmaceutical Applications

Drying Technologies for Biotechnology and Pharmaceutical Applications
Author : Satoshi Ohtake,Ken-ichi Izutsu,David Lechuga-Ballesteros
Publisher : John Wiley & Sons
Release Date : 2020-02-10
Category : Medical
Total pages :400
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A comprehensive source of information about modern drying technologies that uniquely focus on the processing of pharmaceuticals and biologicals Drying technologies are an indispensable production step in the pharmaceutical industry and the knowledge of drying technologies and applications is absolutely essential for current drug product development. This book focuses on the application of various drying technologies to the processing of pharmaceuticals and biologicals. It offers a complete overview of innovative as well as standard drying technologies, and addresses the issues of why drying is required and what the critical considerations are for implementing this process operation during drug product development. Drying Technologies for Biotechnology and Pharmaceutical Applications discusses the state-of-the-art of established drying technologies like freeze- and spray- drying and highlights limitations that need to be overcome to achieve the future state of pharmaceutical manufacturing. The book also describes promising next generation drying technologies, which are currently used in fields outside of pharmaceuticals, and how they can be implemented and adapted for future use in the pharmaceutical industry. In addition, it deals with the generation of synergistic effects (e.g. by applying process analytical technology) and provides an outlook toward future developments. -Presents a full technical overview of well established standard drying methods alongside various other drying technologies, possible improvements, limitations, synergies, and future directions -Outlines different drying technologies from an application-oriented point of view and with consideration of real world challenges in the field of drug product development -Edited by renowned experts from the pharmaceutical industry and assembled by leading experts from industry and academia Drying Technologies for Biotechnology and Pharmaceutical Applications is an important book for pharma engineers, process engineers, chemical engineers, and others who work in related industries.

Cancer Vaccines

Cancer Vaccines
Author : Adrian Bot,Mihail Obrocea,Francesco M. Marincola
Publisher : CRC Press
Release Date : 2015-05-06
Category : Medical
Total pages :280
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Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: From Research to Clinical Practice is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist. Cancer Vaccines: From Research to Clinical Practice: Analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential Discusses "theranostics" as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics

Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics
Author : Lisa Plitnick,Danuta Herzyk
Publisher : Academic Press
Release Date : 2013-06-27
Category : Medical
Total pages :432
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Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics. Provides in-depth coverage of the process of nonclinical safety assessment and comprehensive reviews of each type of biopharmaceutical Contains the most pertinent international regulatory guidance documents for nonclinical evaluation Covers early de-risking strategies and designs of safety assessment programs for novel biopharmaceuticals and vaccines, as well as follow-on biologics or "biosimilars" A multi-authored book with chapters written by qualified experts in their respective fields

Mucosal Delivery of Drugs and Biologics in Nanoparticles

Mucosal Delivery of Drugs and Biologics in Nanoparticles
Author : Pavan Muttil,Nitesh K. Kunda
Publisher : Springer Nature
Release Date : 2020-03-18
Category : Medical
Total pages :277
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Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Annual Meeting Proceedings

Annual Meeting Proceedings
Author : American Society of Clinical Oncology. Meeting
Publisher : Unknown
Release Date : 2008
Category :
Total pages :129
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Pancreatic Cancer

Pancreatic Cancer
Author : Andrew M. Lowy,Steven D. Leach,Philip Philip
Publisher : Springer Science & Business Media
Release Date : 2008-07-10
Category : Medical
Total pages :744
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Since the previous M.D. Anderson Solid Tumor Oncology Series publication on pancreatic cancer, there have been major advances in our understanding of molecular events which underlie pancreatic cancer development, both in the sporadic and inherited forms. This book provides information on the recent progress and improvements. It brings to the forefront the most current advances that have been made in understanding pancreatic cancer development and successfully treating this disease.

Medical Management of the Thoracic Surgery Patient E-Book

Medical Management of the Thoracic Surgery Patient E-Book
Author : Michael I. Lewis,Robert J. McKenna
Publisher : Elsevier Health Sciences
Release Date : 2009-10-30
Category : Medical
Total pages :560
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Medical Management of the Thoracic Surgery Patient, by Michael I. Lewis, MD and Robert J. McKenna, Jr., MD, is a comprehensive pulmonary and thoracic reference that takes a practical approach to the diagnosis, workup and care of the thoracic surgery patient. It is geared towards pulmonary and critical care physicians and their trainees as well as all other specialties with whom thoracic surgeons consult and interact. It outlines the principles for understanding the underlying disease entities as well as the clinical implications and complications of surgery, and interprets key surgical concepts such as correlative and functional anatomy for non-surgeons. Contributions from today’s authorities...“at-a-glance detailed key information, as well as summary bullets...and a multidisciplinary perspective, combine to offer essential guidance for confident patient management. As an Expert Consult title it includes convenient online access to the complete contents of the book—fully searchable—along with video clips of thoracic procedures, patient information sheets, all of the images downloadable for your personal use, and references linked to Medline at www.expertconsult.com. Includes access to a companion website at expertconsult.com where you can search the complete contents of the book, watch video clips of thoracic procedures, print out patient information sheets, download all of the images, and review references linked to Medline...providing you with a powerful resource for convenient consultation anytime, anywhere. Features ‘real world’ illustrative cases presented in a brief, bulleted format that facilitates easy access to and retention of the material. Examines every aspect of diagnosis and management for pre-, peri-, and postoperative care for an all-encompassing reference to respond to unique surgical problems. Provides coverage of individual topics supplemented by a brief case-based presentation, where appropriate, that lend a real-life perspective to the material. Contains all of the “need-to-know facts for a complete, thorough consultation in diagnosis and treatment of patients who undergo thoracic surgery. Offers practical information that utilizes the experience of today’s leaders while based on evidence in the literature for coverage you can trust. Examines current clinical controversies, providing you with an arena for discussion of sensitive topics and guidance on preferred approaches when relevant. Presents pearls, pitfalls, key points, and other learning elements in each chapter, to help you locate summaries of essential information “at-a-glance. Features chapters written by specialists of various disciplines, to equip you with a balanced perspective on each condition.

40th Annual Meeting of the American Society of Clinical Oncology

40th Annual Meeting of the American Society of Clinical Oncology
Author : American Society of Clinical Oncology. Annual Meeting,American Society of Clinical Oncology
Publisher : Unknown
Release Date : 2004
Category : Cancer
Total pages :1064
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Novel Therapies in Head and Neck Cancer: Beyond the Horizon

Novel Therapies in Head and Neck Cancer: Beyond the Horizon
Author : Maie A. St. John,No hee Park
Publisher : Academic Press
Release Date : 2020-06-29
Category : Science
Total pages :266
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Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients. Covers new chemotherapy trials, specifically on HPV and non-HPV related cancer types Discusses the application of immunotherapy to treat rare types of head and neck cancer Presents updated information on targeted therapies, specifically focusing on skin cancer in the region

Pharmaceutical Biotechnology

Pharmaceutical Biotechnology
Author : Carlos A. Guzmán,Giora Z. Feuerstein
Publisher : Springer Science & Business Media
Release Date : 2010-01-01
Category : Medical
Total pages :276
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Pharmaceutical Biotechnology is a unique compilation of reviews addressing frontiers in biologicals as a rich source for innovative medicines. This book fulfills the needs of a broad community of scientists interested in biologicals from diverse perspectives—basic research, biotechnology, protein engineering, protein delivery, medicines, pharmaceuticals and vaccinology. The diverse topics range from advanced biotechnologies aimed to introduce novel, potent engineered vaccines of unprecedented efficacy and safety for a wide scope of human diseases to natural products, small peptides and polypeptides engineered for discrete prophylaxis and therapeutic purposes. Modern biologicals promise to dramatically expand the scope of preventive medicine beyond the infectious disease arena into broad applications in immune and cancer treatment, as exemplified by anti-EGFR receptors antibodies for the treatment of breast cancer. The exponential growth in biologicals such as engineered proteins and vaccines has been boosted by unprecedented scientific breakthroughs made in the past decades culminating in an in-depth fundamental understanding of the scientific underpinnings of immune mechanisms together with knowledge of protein and peptide scaffolds that can be deliberately manipulated. This has in turn led to new strategies and processes. Deciphering the human, mammalian and numerous pathogens’ genomes provides opportunities that never before have been available—identification of discrete antigens (genomes and antigenomes) that lend themselves to considerably improved antigens and monoclonal antibodies, which with more sophisticated engineered adjuvants and agonists of pattern recognition receptors present in immune cells, deliver unprecedented safety and efficacy. Technological development such a nanobiotechnologies (dendrimers, nanobodies and fullerenes), biological particles (viral-like particles and bacterial ghosts) and innovative vectors (replication-competent attenuated, replication-incompetent recombinant and defective helper-dependent vectors) fulfill a broad range of cutting-edge research, drug discovery and delivery applications. Most recent examples of breakthrough biologicals include the human papilloma virus vaccine (HPV, prevention of women genital cancer) and the multivalent Pneumoccocal vaccines, which has virtually eradicated in some populations a most prevalent bacterial ear infection (i.e., otitis media). It is expected that in the years to come similar success will be obtained in the development of vaccines for diseases which still represent major threats for human health, such as AIDS, as well as for the generation of improved vaccines against diseases like pandemic flu for which vaccines are currently available. Furthermore, advances in comparative immunology and innate immunity revealed opportunities for innovative strategies for ever smaller biologicals and vaccines derived from species such as llama and sharks, which carry tremendous potential for innovative biologicals already in development stages in many pharmaceutical companies. Such recent discoveries and knowledge exploitations hold the promise for breakthrough biologicals, with the coming decade. Finally, this book caters to individuals not directly engaged in the pharmaceutical drug discovery process via a chapter outlining discovery, preclinical development, clinical development and translational medicine issues that are critical the drug development process. The authors and editors hope that this compilation of reviews will help readers rapidly and completely update knowledge and understanding of the frontiers in pharmaceutical biotechnologies.

CRC Critical Reviews in Immunology

CRC Critical Reviews in Immunology
Author : Anonim
Publisher : Unknown
Release Date : 2007
Category : Immunology
Total pages :129
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Indian Journal of Experimental Biology

Indian Journal of Experimental Biology
Author : Anonim
Publisher : Unknown
Release Date : 2004
Category : Biology
Total pages :129
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Journal of the National Cancer Institute

Journal of the National Cancer Institute
Author : Anonim
Publisher : Unknown
Release Date : 2001
Category : Cancer
Total pages :129
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