April 14, 2021

Download Ebook Free Novel Therapies In Head And Neck Cancer: Beyond The Horizon

Novel Therapies in Head and Neck Cancer: Beyond the Horizon

Novel Therapies in Head and Neck Cancer: Beyond the Horizon
Author : Maie A. St. John,No hee Park
Publisher : Academic Press
Release Date : 2020-06-29
Category : Science
Total pages :266
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Novel Therapies in Head and Neck Cancer: Beyond the Horizon, Volume Twelve, provides a high-level synthesis of the latest treatments and outcomes relating to head and neck cancer. Chemotherapy and immunotherapy for those cancer types are rapidly evolving, and an updated source based on the expertise of internationally renowned researchers is necessary. This book discusses the outcome of recent trials using chemotherapy, novel approaches for HPV+ SCCA, cases in which immunotherapy is more likely to be successful, and precision medicine based on target therapies. Additionally, new approaches for rare diseases in head and neck and novel drug delivery platforms are presented. This book will be a very useful source so that students, scientists and clinicians who can be facile with the data, build on what is known, and continue to offer cutting-edge, validated therapies to all patients. Covers new chemotherapy trials, specifically on HPV and non-HPV related cancer types Discusses the application of immunotherapy to treat rare types of head and neck cancer Presents updated information on targeted therapies, specifically focusing on skin cancer in the region

Head and Neck Cancer

Head and Neck Cancer
Author : John Frederick Ensley,Silvio Gutkind,John A. Jacobs,Scott Lippman
Publisher : Elsevier
Release Date : 2003-01-07
Category : Medical
Total pages :602
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By detailing experimental and basic research, from premalignancy to fully invasive tumors, this book has wide applicability to all human carcinomas. No other group of human cancers is better positioned for the application of recently developed novel and targeted therapies, and this book uniquely presents the unusual opportunities tumors of the head and neck provide for clinical, translational, and basic science research. Cutting-edge and experimental treatment approaches are presented, along with future strategies and an evaluation of emerging technologies. Presents a multi-disciplinary perspective from authorities in diverse fields Addresses state-of-the art approaches in cancer research as well as other scientific opportunities in this field Provides comprehensive yet easily comprehendible source of information

pH-Interfering Agents as Chemosensitizers in Cancer Therapy

pH-Interfering Agents as Chemosensitizers in Cancer Therapy
Author : Claudiu Supuran,Simone Carradori
Publisher : Academic Press
Release Date : 2020-09-15
Category : Science
Total pages :228
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pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field. Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered. Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modeling Explains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehension Discusses novel targets to explore new possibilities that enhance research in the field

Overcoming Ovarian Cancer Chemoresistance

Overcoming Ovarian Cancer Chemoresistance
Author : Goli Samimi,Christina Annunziata
Publisher : Academic Press
Release Date : 2020-11-06
Category : Science
Total pages :188
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Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment. The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer. Provides a comprehensive view of both biological and genetic determinants of resistance, as well as technical approaches to monitor response Discusses genetic reversions as a unique alteration and a new field of study Includes a chapter on upcoming and promising agents that are in the pre-clinical and early clinical space, to set the stage for future directions in the field

Therapeutic Strategies to Overcome ALK Resistance in Cancer

Therapeutic Strategies to Overcome ALK Resistance in Cancer
Author : Luc Friboulet
Publisher : Academic Press
Release Date : 2021-01-18
Category : Science
Total pages :216
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Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment. Explains the biology of ALK RTK, focusing on its tissue expression, structure and functionality Presents an overview of current treatments and the benefits of ALK TKI in lung and other cancer types, such as ALCL, neuroblastoma and inflammatory myofibroblastic tumor Encompasses information on systemic treatments other than TKI, including chemotherapy, immunotherapy and antiangiogenic agents in ALK-driven NSCLC

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance
Author : Andrew Freywald,Franco Vizeacoumar
Publisher : Academic Press
Release Date : 2020-12-04
Category : Science
Total pages :308
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Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

AJCC Cancer Staging Manual

AJCC Cancer Staging Manual
Author : Frederick L, Greene,David L. Page,Irvin D. Fleming,April G. Fritz,Charles M. Balch,Daniel G. Haller,Monica Morrow
Publisher : Springer Science & Business Media
Release Date : 2013-11-21
Category : Medical
Total pages :421
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The American Joint Committee on Cancer's Cancer Staging Manual is used by physicians throughout the world to diagnose cancer and determine the extent to which cancer has progressed. All of the TNM staging information included in this Sixth Edition is uniform between the AJCC (American Joint Committee on Cancer) and the UICC (International Union Against Cancer). In addition to the information found in the Handbook, the Manual provides standardized data forms for each anatomic site, which can be utilized as permanent patient records, enabling clinicians and cancer research scientists to maintain consistency in evaluating the efficacy of diagnosis and treatment. The CD-ROM packaged with each Manual contains printable copies of each of the book’s 45 Staging Forms.

Gnepp's Diagnostic Surgical Pathology of the Head and Neck E-Book

Gnepp's Diagnostic Surgical Pathology of the Head and Neck E-Book
Author : Douglas R. Gnepp,Justin A. Bishop
Publisher : Elsevier Health Sciences
Release Date : 2020-05-05
Category : Medical
Total pages :1216
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Offering the most comprehensive collection of head and neck pathology specimens available in one reference, Gnepp’s Diagnostic Surgical Pathology of the Head and Neck, 3rd Edition, is a must-have resource for pathologists in training and practice. This abundantly illustrated volume covers both common and rare disease entities of the entire head and neck area, with particular emphasis on differential diagnosis and diagnostic problems and pitfalls. Detailed text and a highly visual format help you improve turnaround time when diagnosing a specimen and facilitate clear communication of prognosis and therapeutic management options to surgical/medical colleagues. Covers key topics such as molecular aspects of disease, especially in reference to targeted therapy and personalized medicine; the latest classification and staging systems for head and neck diseases and disorders; and immunohistochemical features that help ensure diagnostic accuracy. Discusses new diagnostic biomarkers and their utility in differential diagnosis, as well as newly described variants and new histologic entities. Includes a new chapter on eye pathology. Incorporates new criteria as established by the 2017 World Health Organization classification of Head and Neck tumors and the 2017 World Health Organization classification of Endocrine organ tumors. Provides clinicopathologic correlations throughout to give you all the information you need to formulate a complete diagnostic report. Features more than 1700 full-color illustrations that capture the pathologic appearance of the full range of common and rare neoplastic and non-neoplastic lesions.

Beyond the Horizon: The Frontier

Beyond the Horizon: The Frontier
Author : Peter Watt
Publisher : Pan Australia
Release Date : 2012-10-01
Category : Fiction
Total pages :416
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"the home grown version of Wilbur Smith" The Sunday Age Beyond the Horizon continues the much-loved saga of the Duffys and Macintoshes, told with Peter Watt's trademark mastery of grand scope, family drama and enthralling adventure. It is 1918, a year when the War will end, but an even greater killer will arise. On the bloody fields of the Western Front and the battle-scarred desert plains of the Middle East, Tom and Matthew Duffy are facing the enemy. Even as they are trapped on the front lines, they must also find the courage to fight for the women they love when all hope is lost. Back in Australia, George Macintosh is outraged by the stipulations of his father's will that provide for his despised nephew, and is determined to eliminate any threats to his power. And in a sacred cave in the far Outback, old Wallarie foresees a tide of unspeakable death sweeping through his homeland. As all nations come to terms with the devastating consequences of the Great War, a new world will be born. But not everyone will live to see it. PRAISE FOR THE SERIES "A rousing and revealing yarn" Weekend Australian "the historical detail brings the ... 19th century to rip-roaring life" The Australian "Watt's fans love his work for its history, adventure and storytelling" Brisbane News

Difficult Decisions in Head and Neck Oncologic Surgery

Difficult Decisions in Head and Neck Oncologic Surgery
Author : Zhen Gooi,Nishant Agrawal
Publisher : Springer
Release Date : 2019-07-12
Category : Medical
Total pages :387
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This book provides a practical guide to decision making in head and neck oncologic surgery. As new technology is introduced, there is increasing knowledge regarding the efficacy of traditional head and neck surgical therapies and how to select among these varied and complex approaches is becoming increasingly difficult. Concise easy to follow chapters are devoted to one or two specific questions or decisions in head and neck oncologic surgery, aiding the reader to develop their decision making skills. Difficult Decisions in Head and Neck Oncologic Surgery is a timely reference source for practicing surgeons, surgeons in training, and educators on the recommended ideal approaches in selected clinical situations.

Tuesdays with Morrie

Tuesdays with Morrie
Author : Mitch Albom
Publisher : Crown
Release Date : 2007-06-29
Category : Biography & Autobiography
Total pages :224
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A special 20th anniversary edition of the beloved international bestseller that changed millions of lives Maybe it was a grandparent, or a teacher, or a colleague. Someone older, patient and wise, who understood you when you were young and searching, helped you see the world as a more profound place, gave you sound advice to help you make your way through it. For Mitch Albom, that person was Morrie Schwartz, his college professor from nearly twenty years ago. Maybe, like Mitch, you lost track of this mentor as you made your way, and the insights faded, and the world seemed colder. Wouldn't you like to see that person again, ask the bigger questions that still haunt you, receive wisdom for your busy life today the way you once did when you were younger? Mitch Albom had that second chance. He reconnected with Morrie in the last months of the older man's life. Knowing he was dying, Morrie visited with Mitch in his study every Tuesday, just as they used to back in college. Their rekindled relationship turned into one final "class:" lessons in how to live. Tuesdays with Morrie is a magical chronicle of their time together, through which Mitch shares Morrie's lasting gift with the world.

Head and Neck Cancer

Head and Neck Cancer
Author : Jacques Bernier
Publisher : Springer
Release Date : 2016-08-22
Category : Medical
Total pages :878
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​This second edition ​provides a comprehensive view of consolidated and innovative concepts, in terms of both diagnosis and treatment. Written by leading international physicians and investigators, this book emphasizes the necessity of combining local and systemic treatments to achieve the objective of yielding higher cure rates and lower toxicities. Heavily updated from the previous edition, it highlights new surgery and radiotherapy techniques, disease awareness, patient quality of life, and comprehensive management. Head-and-neck cancers are a complex clinical entity and their response to treatment is also known to vary markedly in function of host-related factors. Notwithstanding the impressive progresses observed in the field of imaging, head and neck cancers are often diagnosed at a late stage and the presence of locally advanced disease in a significant number of patients implies the use of aggressive treatments in order to both ensure local disease control and reduce distant metastasis risks. In comparison with the first edition, Head and Neck Cancer, Second Edition provides a detailed update of innovative concepts in chemo- and bio-radiation, viral infection impact on tumor growth and response to treatment, and impact of tumor- and host-related factors on treatment outcome.

Disease Control Priorities, Third Edition (Volume 6)

Disease Control Priorities, Third Edition (Volume 6)
Author : King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha
Publisher : World Bank Publications
Release Date : 2017-11-06
Category : Medical
Total pages :506
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Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Brain Tumor Immunotherapy

Brain Tumor Immunotherapy
Author : Linda M. Liau,Donald P. Becker,Timothy F. Cloughesy,Darell D. Bigner
Publisher : Springer Science & Business Media
Release Date : 2000-11-10
Category : Medical
Total pages :374
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An authoritative panel of researchers and clinicians critically reviews the entire field to provide a comprehensive guide to modern brain tumor immunotherapy and thereby enhance future research in this area. The contributors detail many of the key laboratory experiments and clinical protocols that are currently being investigated, integrate the available information from previous and ongoing research, and help define the current status of the field. Topics range from adoptive cellular and antibody-mediated immunotherapy of brain tumors to tumor vaccines and related strategies, and include many vanguard experimental strategies and immunological techniques for studying brain tumor immunotherapy. Cutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now harnessing the immune response for brain tumor therapeutics.

Sophie's World

Sophie's World
Author : Jostein Gaarder
Publisher : Farrar, Straus and Giroux
Release Date : 2007-03-20
Category : Fiction
Total pages :544
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One day Sophie comes home from school to find two questions in her mail: "Who are you?" and "Where does the world come from?" Before she knows it she is enrolled in a correspondence course with a mysterious philosopher. Thus begins Jostein Gaarder's unique novel, which is not only a mystery, but also a complete and entertaining history of philosophy.