June 13, 2021

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Nuclear Architecture and Dynamics

Nuclear Architecture and Dynamics
Author : Christophe Lavelle,Jean-Marc Victor
Publisher : Academic Press
Release Date : 2017-10-27
Category : Medical
Total pages :618
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Nuclear Architecture and Dynamics provides a definitive resource for (bio)physicists and molecular and cellular biologists whose research involves an understanding of the organization of the genome and the mechanisms of its proper reading, maintenance, and replication by the cell. This book brings together the biochemical and physical characteristics of genome organization, providing a relevant framework in which to interpret the control of gene expression and cell differentiation. It includes work from a group of international experts, including biologists, physicists, mathematicians, and bioinformaticians who have come together for a comprehensive presentation of the current developments in the nuclear dynamics and architecture field. The book provides the uninitiated with an entry point to a highly dynamic, but complex issue, and the expert with an opportunity to have a fresh look at the viewpoints advocated by researchers from different disciplines. Highlights the link between the (bio)chemistry and the (bio)physics of chromatin Deciphers the complex interplay between numerous biochemical factors at task in the nucleus and the physical state of chromatin Provides a collective view of the field by a large, diverse group of authors with both physics and biology backgrounds

Nuclear Architecture and Dynamics of Stably Integrated Retroviral Sequences

Nuclear Architecture and Dynamics of Stably Integrated Retroviral Sequences
Author : Jens Nagel
Publisher : Unknown
Release Date : 2011
Category :
Total pages :147
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Dynamics and Manipulation of Nuclear Architecture and Gene Expression

Dynamics and Manipulation of Nuclear Architecture and Gene Expression
Author : Katharina Thanisch
Publisher : Unknown
Release Date : 2015
Category :
Total pages :129
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Dynamics of Nuclear Architecture Investigated by Live Cell Microscopy and Quantitative 4-D Reconstruction

Dynamics of Nuclear Architecture Investigated by Live Cell Microscopy and Quantitative 4-D Reconstruction
Author : Daniel Gerlich
Publisher : Unknown
Release Date : 2002
Category :
Total pages :68
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Nuclear Architecture and Structural Dynamics

Nuclear Architecture and Structural Dynamics
Author : Josef H. Exler
Publisher : Unknown
Release Date : 2010
Category :
Total pages :181
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Nuclear Architecture Dynamics in Tadpole Tail Regeneration

Nuclear Architecture Dynamics in Tadpole Tail Regeneration
Author : Jessica Kay Chang
Publisher : Unknown
Release Date : 2019
Category :
Total pages :129
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Mammals possess very limited regeneration capabilities, where the few examples of scarless healing tend to be restricted to early development. In light of this, it is of great interest to study animals that can faithfully regrow complete appendages, and uncover the biological properties that facilitate regeneration. Xenopus tropicalis is an excellent vertebrate model of regeneration, as tadpoles rapidly regenerate amputated tails, a process that has an interesting developmental history that may be widely informative as to why mammals selectively heal through scarring as they age. Though we have some understanding of what processes are required for tail regeneration, we have yet to systematically chronicle the molecular and regulatory events that must set up an apparently coordinated response. In this dissertation, I address two primary questions in the field of regeneration—what molecular events occur in the first 24 hours to set up a potent regenerative bud, and how is this process regulated? In Chapter 2, I chronicle the transcriptional history of tadpole tail regeneration, focusing primarily within the first 24 hours post amputation. In Chapter 3, I describe a novel nuclear morphology I identified in the tadpole tail, detail how nuclei change shape as an early regeneration response, and investigate the relationship between nuclear shape and chromatin state. Finally, in Chapter 4, I address several future directions with respect to this thesis.

Chromatin Regulation and Dynamics

Chromatin Regulation and Dynamics
Author : Anita Göndör
Publisher : Academic Press
Release Date : 2016-10-25
Category : Science
Total pages :496
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Chromatin Regulation and Dynamics integrates knowledge on the dynamic regulation of primary chromatin fiber with the 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes. The final chapters discuss the many ways chromatin dynamics can synergize to fundamentally contribute to the development of complex diseases. Chromatin dynamics, which is strategically positioned at the gene-environment interface, is at the core of disease development. As such, Chromatin Regulation and Dynamics, part of the Translational Epigenetics series, facilitates the flow of information between research areas such as chromatin regulation, developmental biology, and epidemiology by focusing on recent findings of the fast-moving field of chromatin regulation. Presents and discusses novel principles of chromatin regulation and dynamics with a cross-disciplinary perspective Promotes crosstalk between basic sciences and their applications in medicine Provides a framework for future studies on complex diseases by integrating various aspects of chromatin biology with cellular metabolic states, with an emphasis on the dynamic nature of chromatin and stochastic principles Integrates knowledge on the dynamic regulation of primary chromatin fiber with 3D nuclear architecture, then connects related processes to circadian regulation of cellular metabolic states, representing a paradigm of adaptation to environmental changes

Nuclear Dynamics

Nuclear Dynamics
Author : K. Nagata,K. Takeyasu
Publisher : Springer Science & Business Media
Release Date : 2007-12-03
Category : Science
Total pages :279
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The dynamics of nuclear structures described in this book furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.

Visualizing the Dynamics of 4D Nuclear Architecture During Enhancer-Promoter Transcription Activation Using Live Imaging Techniques

Visualizing the Dynamics of 4D Nuclear Architecture During Enhancer-Promoter Transcription Activation Using Live Imaging Techniques
Author : Leah Kim
Publisher : Unknown
Release Date : 2020
Category :
Total pages :31
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The transcription machinery requires spatiotemporal coordination of its regulatory elements for precise gene expression. It is believed that the dynamics in the nuclear architecture like enhancer:promoter looping interaction is essential for the regulation of the transcription machinery. However, the detail of the change in 4D nuclear architecture during transcription is poorly understood. Here we seek to visualize a pair of enhancer and its associated target gene based on a real time, live cell imaging that uses optimized CRISPR-Cas9 and MS2/PP7 system. Our prior work on measuring TFF1 transcription bursting in MCF7 cells confirmed the efficiency and sensitivity of our imaging techniques. In this study, we aim to visualize c-MYC enhancer(c-MYCe) and c-MYC gene in live HeLa cells based on our preliminary data proving that c-MYC enhancer is a functional enhancer. We plan to measure the relative timing of signal, the duration of activity, and the distribution of intensity over the course of activity. The spatial kinetics between c-MYCe and c-MYC over time will be measured, and their motion relative to transcriptional activity (on/off signal) will be examined. Collectively, we hope to advance the understanding of the precise 4D dynamics of the events underlying enhancer-mediated transcription regulation.

Architecture and Dynamics of Isotopically Labelled Macromolecules by Nuclear Magnetic Resonance Spectroscopy

Architecture and Dynamics of Isotopically Labelled Macromolecules by Nuclear Magnetic Resonance Spectroscopy
Author : Anonim
Publisher : Unknown
Release Date : 1979
Category :
Total pages :129
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The use of 13C is considered using NMR spectra of cell suspensions. Biochemical reaction kinetics are still unclear in the study of environmental and structural perturbations of amino acids and peptides; thus needs still exist for this labelling technique. (PCS).

Nuclear Dynamics of Radiation-induced Foci in Euchromatin and Heterochromatin

Nuclear Dynamics of Radiation-induced Foci in Euchromatin and Heterochromatin
Author : Anonim
Publisher : Unknown
Release Date : 2013
Category :
Total pages :11
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Repair of double strand breaks (DSBs) is essential for cell survival and genome integrity. While much is known about the molecular mechanisms involved in DSB repair and checkpoint activation, the roles of nuclear dynamics of radiation-induced foci (RIF) in DNA repair are just beginning to emerge. Here, we summarize results from recent studies that point to distinct features of these dynamics in two different chromatin environments: heterochromatin and euchromatin. We also discuss how nuclear architecture and chromatin components might control these dynamics, and the need of novel quantification methods for a better description and interpretation of these phenomena. These studies are expected to provide new biomarkers for radiation risk and new strategies for cancer detection and treatment.

Nuclear Envelope Dynamics in Embryos and Somatic Cells

Nuclear Envelope Dynamics in Embryos and Somatic Cells
Author : Philippe Collas
Publisher : Springer
Release Date : 2012-11-01
Category : Science
Total pages :174
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This volume provides an exhaustive review of the most current knowledge of the composition, architecture and dynamics of the nuclear envelope. In contrast to other comprehensive works on cellular membranes in general, this book is the first to specifically address the nuclear envelope. Experts in the field relate the different domains of the nuclear envelope, their biogenesis, their composition, their mode of targeting to chromosomes and how they dissociate from chromosomes upon cell division. A wealth of information from several experimental systems is provided, such as dividing somatic cells, embryos and nuclear assembly assays in cell-free extracts, in a wide range of vertebrate and invertebrate organisms ranging from humans to yeast. The book also contains up-to-date reviews on the relationship between mutations in proteins of the nuclear envelope and Emery-Dreifuss muscular dystrophy. The breadth of topics covered in what may seem to be a field as narrow as the nuclear envelope makes this volume a valuable reference.

Organization, Dynamics and Modification of Chromatin in Plants

Organization, Dynamics and Modification of Chromatin in Plants
Author : A. Houben,T. Naranjo,M. J. Puertas
Publisher : Unknown
Release Date : 2014-08-19
Category : Medical
Total pages :220
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This special topic issue is divided into two sections, and each of them presents its own set of reviews and research articles. 'Organization and dynamics of plant chromatin' is the title of the first section which explores an ample variety of subjects. The topics covered include the structure and function of meiotic chromosomes, open chromatin, nuclear architecture and chromatin dynamics and proteomic analysis of plant cell nuclei. 'Epigenetic modification of plant chromatin' is the title of the second section. This provides a broad array of studies on various plant species and epigenetic modification of plant chromatin. This novel approach represents one of the most interesting developments in research in the field of modern cytogenetics.'Organization, Dynamics and Modification of Chromatin in Plants' is of particular interest to researchers and teachers in genetics and cytology.

Advances in Nuclear Architecture

Advances in Nuclear Architecture
Author : Niall M. Adams,Paul S. Freemont
Publisher : Springer Science & Business Media
Release Date : 2010-10-17
Category : Medical
Total pages :210
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This book provides a snapshot of the state-of-the art in the study of mammalian cell nuclear architecture, and features a diverse range of chapters written by top researchers. A key aspect is an emphasis on precise and repeatable quantitative analysis and simulation in addition to the more familiar biological perspective. The fusion of such material frames the future of the discipline. Quantitative contributions stress reproducible and robust 3D analysis, using a variety of tools ranging from point pattern analysis to shape registration methods. Biological insights include the role of nuclear subdomains in cancer, nuclear molecular motors, and a holistic view of gene transcription.