November 26, 2020

Download Ebook Free Ocular Transporters And Receptors

Ocular Transporters and Receptors

Ocular Transporters and Receptors
Author : Ashim K Mitra
Publisher : Elsevier
Release Date : 2013-10-31
Category : Science
Total pages :276
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Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye. Highly focused on ocular transporters Most up-to-date research compilation Detailed description of role of transporters and receptors in ocular drug discovery and delivery

Ocular Transporters in Ophthalmic Diseases and Drug Delivery

Ocular Transporters in Ophthalmic Diseases and Drug Delivery
Author : Joyce Tombran-Tink,Colin J. Barnstable
Publisher : Springer Science & Business Media
Release Date : 2008-04-09
Category : Medical
Total pages :467
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In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.

The Biology of the Eye

The Biology of the Eye
Author : Jorge Fischbarg
Publisher : Elsevier
Release Date : 2005-12-09
Category : Science
Total pages :406
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Acknowledgement This book is the result of a collective effort. Due to an oversight, mention of three of the contributors who played an especially decisive role in bringing the work to fruition was omitted from the book. They should share fully in the intellectual credits accruing from this publication. I would therefore like to acknowledge and thank the following for their outstanding contributions to editing the work: Dr. Morten Dornonville la Cour (MD, Dr. Med. Sci.) solicited and edited the chapters on retina, RPE, choroid, vitreous, immunology, and sclera. Dr. la Cour is a Lecturer, Eye Department, Copenhagen University Hospital, specializes in vitreoretinal surgery, and frequently lectures in the international scene. A trained mathematician, he has done research in retinal pigment epithelial physiology in the laboratories of Drs. Thomas Zeuthen and Sheldon Miller. Dr. Friedrich P.J. Diecke and Dr. Elliott M. Kanner also provided invaluable editorial assistance. Dr Diecke, who was formerly Professor and Chairman of the Department of Physiology, UMDNJ-New Jersey Medical School, is a Professor Emeritus at that institution. His research has concentrated on membrane transport mechanisms in lens epithelial cells, corneal endothelial cells and peripheral nerve and on the regulation of vascular smooth muscle contraction. Dr. Elliott M. Kanner was born in Canada in 1970. He graduated from Yale University in 1992 with a BS/MS degree in Molecular Biophysics and Biochemistry. He received his PhD degree from the Rockefeller University in 1999 and his MD degree from Weill/Cornell in 2001. He is currently an Ophthalmology resident at Columbia University. Jorge Fischbarg, December 2005 This book explores the many recent novel ideas about the eye in a systematic and synthetic way. It includes both basic sciences and applications towards clinical research. Chapters include both anatomical and functional descriptions of the different ocular tissues and treatments of a few subjects of practical importance for ophthalmologists. This book is intended for students in basic biomedical science interested in the eye, as well as ophthalmologists a comprehensive source on recent developments in ocular research. * Combines basic science and practical opthalmological subjects * Written with the simplicity of a textbook, while maintaining the comprehensive and rigorous approach of science papers * Includes contributions by well-known experts

Cell Biology of the Eye

Cell Biology of the Eye
Author : David Mcdevitt
Publisher : Elsevier
Release Date : 2012-12-02
Category : Nature
Total pages :584
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Cell Biology of the Eye discusses the eye tissues and its role in the investigations on active transport, growth factors, receptors, and differentiation. The book is comprised of articles which discuss corneal proteoglycans; transport of ions and metabolites across the corneal endothelium; the ontogeny and localization of the crystallins in eye lens development and regeneration; the biological-physical basis of lens transparency; the chromatic organization of the retina; and the dopamine neurons in the retina. This treatise will serve as a valuable reference text for graduate and professional students, teachers, researchers, clinicians, and to all in the vision field.

Pharmacologic Therapy of Ocular Disease

Pharmacologic Therapy of Ocular Disease
Author : Scott M. Whitcup,Dimitri T. Azar
Publisher : Springer
Release Date : 2017-06-22
Category : Medical
Total pages :389
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There have been major advancements in the pharmacologic treatment of eye diseases over the past decade. With newly discovered disease targets and novel approaches to deliver therapeutic compounds to the eye, patients are seeing improved outcomes. Not only are there better treatments for diseases where treatments existed, we now have effective therapy for previously untreatable and blinding eye disorders. This volume will cover the pharmacologic treatment of eye diseases from the front of the eye including eyelids, conjunctiva and cornea all the way back to the retina and optic nerve. The first section of the volume reviews general principles of ocular pharmacology, pharmacokinetics, pharmaceutical sciences, and drug delivery. In addition, the volume provides an up to date guide to the pharmacologic approach to the key eye diseases that threaten sight or ocular function.

Pharmacology of Ocular Therapeutics

Pharmacology of Ocular Therapeutics
Author : Thirumurthy Velpandian
Publisher : Springer
Release Date : 2016-02-29
Category : Medical
Total pages :535
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This book comprises an integrated review of ocular therapeutics across all relevant fields. It addresses the real-world requirements of ophthalmologists, pharmacists and optometrists, as observed through working alongside these practitioners for two decades. Knowledge surrounding agents used in ophthalmic practice has, historically, been scattered. The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents. Chapters detail drug transfer across barriers, systemic toxicity of topically applied drugs, autonomic drugs used for diagnostics, as well as anti-inflammatory, antiallergic, glaucoma and antimicrobial therapies, and avenues for the development of new ocular drugs. Applications of extemporaneously prepared formulations are described to inform day-to-day clinical practice. The use of mucoadhesive polymers in tear substitutes, ocular drug delivery systems, stem cell therapy, pharmacogenomics and antiangiogenic ocular chemotherapy are also explored. The book also provides insights from drugs of herbal origin, and a historical perspective on drugs for ocular use. Practicing and resident ophthalmologists, optometrists, pharmacists, nursing professionals, scholars in ocular drug research and students will equally benefit from this comprehensive guide.

Handbook of Nutrition, Diet and the Eye

Handbook of Nutrition, Diet and the Eye
Author : Victor R. Preedy
Publisher : Academic Press
Release Date : 2014-04-01
Category : Technology & Engineering
Total pages :704
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The Handbook of Nutrition, Diet and the Eye is the first book to thoroughly address common features and etiological factors in how dietary and nutritional factors affect the eye. The ocular system is perhaps one of the least studied organs in diet and nutrition, yet the consequences of vision loss can be devastating. One of the biggest contributors to complete vision loss in the western hemisphere is diabetes, precipitated by metabolic syndrome. In some developing countries, micronutrient deficiencies are major contributory factors to impaired vision. However, there are a range of ocular defects that have either their origin in nutritional deficiencies or excess or have been shown to respond favorably to nutritional components. The eye from the cornea to the retina may be affected by nutritional components. Effects may be physiological or molecular. This book represents essential reading for nutritionists, dietitians, optometrists, ophthalmologists, opticians, endocrinologists, and other clinicians and researchers interested in eye health and vision in general. Saves clinicians and researchers time in quickly accessing the very latest details on a broad range of nutrition, ocular health, and disease issues Provides a common language for nutritionists, nutrition researchers, optometrists, and ophthalmologists to discuss how dietary and nutritional factors, and related diseases and syndromes affect the eye Preclinical, clinical, and population studies will help nutritionists, dieticians, and clinicians map out key areas for research and further clinical recommendations

Anatomy ;Ocular physiology ;Biochemistry and genetics ;Pathology ;Microbiology ;Immunology ;Growth and senescence ;Optics ;Therapeutics ;Lasers and instrument technology ;Basic biostatistical and epidemiological terms

Anatomy ;Ocular physiology ;Biochemistry and genetics ;Pathology ;Microbiology ;Immunology ;Growth and senescence ;Optics ;Therapeutics ;Lasers and instrument technology ;Basic biostatistical and epidemiological terms
Author : Louise Bye,Neil Modi,Miles Stanford
Publisher : OUP Oxford
Release Date : 2013-05-23
Category : Medical
Total pages :288
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An indispensable and fully comprehensive textbook, this covers the basic sciences in ophthalmology and is the only book you need to pass the FRCOphth Part 1 exam.

Drug Product Development for the Back of the Eye

Drug Product Development for the Back of the Eye
Author : Uday B. Kompella,Henry F. Edelhauser
Publisher : Springer Science & Business Media
Release Date : 2011-08-03
Category : Medical
Total pages :592
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This comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs. Specific topics covered in this book include: Solution, suspension, gel, nanoparticle, microparticle, and implant dosage forms Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering.

Ocular Disease: Mechanisms and Management E-Book

Ocular Disease: Mechanisms and Management E-Book
Author : Leonard A Levin,Daniel M. Albert
Publisher : Elsevier Health Sciences
Release Date : 2010-03-10
Category : Medical
Total pages :704
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Ocular Disease—a newly introduced companion volume to the classic Adler’s Physiology of the Eye—correlates basic science and clinical management to describe the how and why of eye disease processes and the related best management protocols. Editors Leonard A. Levin and Daniel M. Albert—two of the world’s leading ophthalmic clinician-scientists—have recruited as contributors the most expert and experienced authorities available in each of the major areas of ophthalmic disease specific to ophthalmology: retina, cornea, cataract, glaucoma, uveitis, and more. The concise chapter structure features liberal use of color—with 330 full-color line artworks, call-out boxes, summaries, and schematics for easy navigation and understanding. This comprehensive resource provides you with a better and more practical understanding of the science behind eye disease and its relation to treatment. Covers all areas of disease in ophthalmology including retina, cornea, cataract, glaucoma, and uveitis for the comprehensive information you need for managing clinical cases. Presents a unique and pragmatic blend of necessary basic science and clinical application to serve as a clinical guide to understanding the cause and rational management of ocular disease. Features 330 full-color line artworks that translate difficult concepts and discussions into concise schematics for improved understanding and comprehension. Provides the expert advice of internationally recognized editors with over 40 years of experience together with a group of world class contributors in basic science and clinical ophthalmology.

Mechanisms of Water and Solute Transport at the Ocular Surface

Mechanisms of Water and Solute Transport at the Ocular Surface
Author : Marc Harris Levin
Publisher : Unknown
Release Date : 2006
Category :
Total pages :275
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Actions of and interactions among AQPs, CFTR, and ENaC are also of central importance to airway surface liquid (ASL) function and dysfunction, and have been considered with regard to both the etiology and possible treatment of cystic fibrosis (CF) lung disease. Recent data indicated clinical benefit of nebulized hypertonic saline in CF. The proposed mechanism of increased ASL volume relies on purported inhibition of lung AQPs by the ENaC inhibitor amiloride. Sensitive fluorescence methods indicated that amiloride does not inhibit AQP-mediated airway water permeability, indicating the need to identify alternate mechanisms for clinical benefit of hypertonic saline.

Drug Delivery

Drug Delivery
Author : Ashim K. Mitra,Chairman and Curator's Professor Pharmaceutical Sciences University of Missouri Kansas City Missouri Ashim K Mitra,Deep Kwatra,Aswani Dutt Vadlapudi
Publisher : Jones & Bartlett Publishers
Release Date : 2014-08-18
Category : Medical
Total pages :400
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Drug Delivery is the latest and most up-to-date text on drug delivery and offers an excellent working foundation for students and clinicians in health professions and graduate students including nursing, pharmacy, medicine, dentistry, as well as researchers and scientists. Presenting this complex content in an organized and concise format, Drug Delivery allows students to gain a strong understanding of the key concepts of drug delivery.This text focuses on the basic concepts of drug delivery while thoroughly examining various topics such as: CNS delivery Gene delivery Ocular delivery World-wide research on drug delivery Recent advances in drug deliveryA significant advancement has been made in the field of drug delivery. This text provides a detailed overview of drug delivery systems, routes of drug administration and development of various formulations. The cutting edge research being carried out in this field will be compiled and a focus on worldwide research on drug delivery and targeting at the molecular, cellular, and organ levels will also be summarized.Each new print copy includes access to the Navigate Companion Website including: Chapter Quizzes, Interactive Glossary, Crossword Puzzles , Interactive Flashcards, and Matching Exercises

Advances in Ocular Hypertension Research and Treatment: 2011 Edition

Advances in Ocular Hypertension Research and Treatment: 2011 Edition
Author : Anonim
Publisher : ScholarlyEditions
Release Date : 2012-01-09
Category : Medical
Total pages :122
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Advances in Ocular Hypertension Research and Treatment: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Ocular Hypertension in a concise format. The editors have built Advances in Ocular Hypertension Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Ocular Hypertension in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Ocular Hypertension Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Clinical Anatomy of the Visual System E-Book

Clinical Anatomy of the Visual System E-Book
Author : Lee Ann Remington,Denise Goodwin
Publisher : Elsevier Health Sciences
Release Date : 2011-07-29
Category : Medical
Total pages :302
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Taking the place of the multiple texts traditionally needed to cover visual anatomy and physiology, Clinical Anatomy and Physiology of the Visual System, 3rd Edition dramatically lightens your load by providing one book that covers it all! This concise, well-referenced resource contains information on the clinical anatomy of the eye, its adnexa and visual pathways, histologic information, plus newly added content on physiology of the human ocular structures. Vivid illustrations complement the text and provide clinical information on diseases and disorders that represent departures from normal clinical anatomy. Comprehensive physiology coverage clarifies the integration between structure and function, eliminating your need for multiple books on the anatomy and physiology of the visual system. An emphasis on clinical application helps you better understand the processes that occur in disease and dysfunction. Genetic information keeps you current with the latest developments in visual anatomy and physiology. Full-color illustrations throughout the text enhance your understanding of anatomical and clinical information. UNIQUE! Clinical Comment sections provide a solid foundation for recognizing and understanding clinical situations, conditions, diseases, and treatments. Photos of normal eye structures illustrate clinical appearance and demonstrate how appearance is directly related to structure. Geriatric coverage, including aging changes in ocular tissue and the visual pathway, keeps you up-to-date with the expanding field of geriatric care. UNIQUE! Expert coverage written by an actual optometrist gives you a practical framework for recognizing and understanding clinical situations, problems, and treatments.

Drug-Induced Ocular Side Effects: Clinical Ocular Toxicology E-Book

Drug-Induced Ocular Side Effects: Clinical Ocular Toxicology E-Book
Author : Frederick T. Fraunfelder,Frederick W. Fraunfelder,Wiley A. Chambers
Publisher : Elsevier Health Sciences
Release Date : 2014-09-19
Category : Medical
Total pages :424
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Ideal for ophthalmologists, optometrists and busy clinicians, Drug-Induced Ocular Side Effects provides the clinically relevant information you need to diagnose and manage chemical and drug-related ocular problems. An easily accessible format, meticulous revisions and comprehensive coverage of all drugs’ generic and trade names, primary uses, ocular and systemic side effects, and clinical significance make this best-selling resource the ideal reference for quick, on-the-spot consultation. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Manage any challenge in ocular toxicology with extensive coverage of principles of therapy; ocular drug delivery; methods to evaluate drug-induced visual side effects; and the role of electrophysiology and psychophysics. Benefit from the masterful guidance and global perspective of world authorities in the field who provide need-to-know information on all aspects of ocular toxicology—all in one concise reference. Confer with the WHO classification system to determine whether a particular side effect is certain, probable, or likely to occur. Zero in on the key information you need to know with highly templated, concise chapters. Apply the latest knowledge and treatments for newly recognized Adverse Drug Reactions (ADR). Identify which ADR’s are clinically relevant and what to do about them. Experience clinical scenarios with vivid clarity through a wealth of new and updated clinical photographs that provide unmatched, visual diagnostic guidance. Recognize and avoid drug-induced ocular side effects with data from the National Registry of Drug Induced Ocular Side-Effects (Casey Eye Institute, Portland, OR) and the World Health Organization (Uppsala, Sweden). Stay up to date and provide state-of-the-art care with the latest information on approved medications.