November 24, 2020

Download Ebook Free Organic Synthesis Using Biocatalysis

Organic Synthesis Using Biocatalysis

Organic Synthesis Using Biocatalysis
Author : Animesh Goswami,Jon D. Stewart
Publisher : Academic Press
Release Date : 2015-09-06
Category : Science
Total pages :438
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Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. Provides a concise background of the application of biocatalysis for the synthesis of organic compounds Expert contributors present recipes for carrying out biocatalytic reactions, including subject worthy discussions on biocatalysis in organic synthesis, biocatalysis for selective organic transformation, enzymes as catalysis for organic synthesis, biocatalysis in Industry, including pharmaceuticals, and more Contains detailed, separate chapters that describe the application of biocatalysis

Biocatalysis in Organic Synthesis

Biocatalysis in Organic Synthesis
Author : Nicholas J. Turner,Luke Humphreys
Publisher : Royal Society of Chemistry
Release Date : 2018-02-08
Category :
Total pages :429
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The application of biocatalysis in organic synthesis is rapidly gaining popularity amongst chemists. Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials. Together these advantages can contribute to more sustainable manufacturing processes across a wide range of industries ranging from pharmaceuticals to biofuels. The biocatalytic toolbox has expanded significantly in the past five years and given the current rate of development of new engineered biocatalysts it is likely that the number of available biocatalysts will double in the next few years. This textbook gives a comprehensive overview of the current biocatalytic toolbox and also establishes new guidelines or rules for “biocatalytic retrosynthesis”. Retrosynthesis is a well known and commonly used technique whereby organic chemists start with the structure of their target molecule and generate potential starting materials and intermediates through a series of retrosynthetic disconnections. These disconnections are then used to devise a forward synthesis, in this case using biocatalytic transformations in some of the key steps. Target molecules are disconnected with consideration for applying biocatalysts, as well as chemical reagents and chemocatalysts, in the forward synthesis direction. Using this textbook, students will be able to place biocatalysis within the context of other synthetic transformations that they have learned earlier in their studies. This additional awareness of biocatalysis will equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. In addition to guidelines for identifying where biocatalysts can be applied in organic synthesis, this textbook also provides examples of current applications of biocatalysis using worked examples and case studies. Tutorials enable the reader to practice disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. The book contains a complete description of the current biocatalyst classes that are available for use and also suggests areas where new enzymes are likely to be developed in the next few years. This textbook is an essential resource for lecturers and students studying synthetic organic chemistry. It also serves as a handy reference for practicing chemists who wish to embed biocatalysis into their synthetic toolbox.

Organic Synthesis with Enzymes in Non-Aqueous Media

Organic Synthesis with Enzymes in Non-Aqueous Media
Author : Giacomo Carrea,Sergio Riva
Publisher : John Wiley & Sons
Release Date : 2008-04-09
Category : Science
Total pages :328
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Closing a gap in the literature, this comprehensive book examines and discusses different non-aqueous systems from organic solvents to ionic liquids for synthetic applications, thus opening the door to new successful methods for biocatalytic reactions. It gathers into one handy source the information otherwise widely spread throughout the literature, combining useful background information with a number of synthetic examples, including industrial scale processes for pharmaceutical and fine chemicals. Extremely well structured, the text introduces the fundamentals of non-aqueous enzymology, before going on to new reaction media and synthetic applications using hydrolases and non-hydrolytic enzymes. The one-stop reference for everyone working in this hot field.

Stereoselective Biocatalysis

Stereoselective Biocatalysis
Author : Ramesh N. Patel
Publisher : CRC Press
Release Date : 2000-01-03
Category : Science
Total pages :946
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This book offers an explanation of the specific ways that biocatalysis outperforms chemical catalysis by: utilizing ambient temperature and atmospheric pressure to minimize problems of isomerization, racemization, and epimerization; employing microbial cells and enzymes that can be immobilized and reused over many cycles; and overexpressing enzymes for greater economy and efficiency.

Biocatalysis in Organic Synthesis

Biocatalysis in Organic Synthesis
Author : Kurt Faber,Wolf-Dieter Fessner,N. J. Turner
Publisher : Thieme/Houben-Weyl Series
Release Date : 2015
Category : Science
Total pages :712
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The three Science of Synthesis volumes on Biocatalysis in Organic Synthesis present a broad contemporary overview on the state-of-the-art in enzymatic methods for asymmetric synthesis suitable for academics and industrial researchers working in the field of organic synthesis. The goal is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. Biocatalysis in Organic Synthesis offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis. Volume 3 begins with oxidation. A chapter on enzyme-catalyzed dihydroxylation is followed by reviews of alkane oxidation. Oxidations of alcohols, carbonyl compounds, and heteroatoms are covered, as are halogenations. The use of biocatalysts in total synthesis, cascade reactions, and large-scale industrial applications is considered. Finally, emerging trends are discussed.

Future Directions in Biocatalysis

Future Directions in Biocatalysis
Author : Tomoko Matsuda
Publisher : Elsevier
Release Date : 2017-08-11
Category : Technology & Engineering
Total pages :460
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Future Directions in Biocatalysis, Second Edition, presents the future direction and latest research on how to utilize enzymes, i.e., natural catalysts, to make medicines and other necessities for humans. It emphasizes the most important and unique research on biocatalysis instead of simply detailing the ABC’s on the topic. This book is an indispensable tool for new researchers in the field to help identify specific needs, start new projects that address current environmental concerns, and develop techniques based on green technology. It provides invaluable hints and clues for conducting new research on enzymes, with final sections outlining future directions in biocatalysis further expanding the science into new applications. Gives future directions in the area of biocatalysis research Presents research topics based on their uniqueness, originality, and novelty Includes many explanatory figures to demonstrate concepts to both organic chemists and biochemists Shows that there is no boundary between organic chemistry and biochemistry

Biocatalysis

Biocatalysis
Author : W.-D. Fessner
Publisher : Springer Science & Business Media
Release Date : 2003-09-05
Category : Science
Total pages :254
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Here, leading contributors from the forefront of this exciting technology present authoritative and timely reviews on the state of the art of biocatalysis. They cover the whole spectrum from the discovery of novel enzymes - by modern screening, evolutionary or immunological approaches - through immobilization techniques for technical processes, to their use in the asymmetric synthesis of important target compounds.

Science of Synthesis: Biocatalysis in Organic Synthesis Vol. 1

Science of Synthesis: Biocatalysis in Organic Synthesis Vol. 1
Author : Anonim
Publisher : Georg Thieme Verlag
Release Date : 2015-03-11
Category : Science
Total pages :648
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The three Science of Synthesis volumes on "Biocatalysis in Organic Synthesis" are designed to present the new possibilities offered by modern biocatalysis to the nonspecialist academic and industrial readership who are involved in practical organic synthesis. The goal of the reference work is to help start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. As is the case with all of the Science of Synthesis volumes, "Biocatalysis in Organic Synthesis" offers critical reviews of organic transformations by experts, including typical or general experimental procedures. The content organization of the three volumes is based on the type of reaction performed under biocatalysis. Volume 1 begins with chapters discussing the historical development of the field, sources of enzymes and appropriate selection of catalysts, and general strategies employed in biocatalysis. This is followed by reviews of the biocatalytic hydrolysis of various substrates. The volume concludes with chapters devoted to biocatalytic isomerizations, and the synthesis of glycosides.

Future Directions in Biocatalysis

Future Directions in Biocatalysis
Author : Tomoko Matsuda
Publisher : Elsevier
Release Date : 2011-08-11
Category : Technology & Engineering
Total pages :364
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In Future Directions in Biocatalysis the important topics within biocatalysis and enzymatic catalysis for organic synthesis are described for both experts and non-experts. This books focuses particularly on reactions under development at present and on future advances in the field. Consisting of four sections, this book examines enzymatic reactions under unusual conditions, unique biocatalytic reactions, synthesis of valuable compounds using biocatalysis and the latest molecular biology methods for biocatalysis. Each chapter deals with a specific theme and includes a summary of each area as well as the present state and future direction of research. * Describes methods for solving environmental issues through biocatalysis * Presents the integrated fields of biochemistry and organic chemistry * Unique research topics with high originality

Biocatalysts in Organic Synthesis

Biocatalysts in Organic Synthesis
Author : Jan Halgas,Ján Halgaš
Publisher : Elsevier Science Limited
Release Date : 1992
Category : Science
Total pages :334
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The fundamental problem in modern organic synthesis is the selectivity of preparative organic reactions. This book reflects the recent growth of interest in the use of biocatalysts to attain high chemo-, regio- and particularly, stereoselectivity. Enantiomerically pure compounds are required as building blocks for the synthesis of many new agrochemicals, drugs, or as bioorganic models and probes. The first two chapters are devoted to a brief description of basic properties of various forms of biocatalysts: free and immobilized enzymes, free and immobilized microbial cells and other biopreparations, e.g., monoclonal antibodies. The third chapter deals with different levels of selectivity of biocatalyzed reactions. Attention is paid mainly to the differentiation of enantiomers, enantiotopic groups and faces. The remaining six chapters cover particular types of organic reactions and some 939 references from recent original papers are given. These include substitution reactions, eliminations and additions, synthesis and hydrolysis of esters and amides, oxidations and reductions.Chemists specializing in the synthesis of new biologically active compounds, such as drugs, pesticides, insecticides, insect pheromones, food and cosmetic additives, etc., will find this book of immense value. The book will also be useful as a supplementary textbook for university graduate students taking courses on organic synthesis or bioorganic chemistry.

Biocatalysis for the Pharmaceutical Industry

Biocatalysis for the Pharmaceutical Industry
Author : Junhua (Alex) Tao,Guo-Qiang Lin,Andreas Liese
Publisher : John Wiley & Sons
Release Date : 2009-07-23
Category : Science
Total pages :250
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Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

Biocatalysts and Enzyme Technology

Biocatalysts and Enzyme Technology
Author : Klaus Buchholz,Volker Kasche,Uwe Theo Bornscheuer
Publisher : John Wiley & Sons
Release Date : 2012-12-21
Category : Science
Total pages :626
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This second edition of a bestselling textbook offers an instructive and comprehensive overview of our current knowledge of biocatalysis and enzyme technology. The book now contains about 40% more printed content. Three chapters are completely new, while the others have been thoroughly updated, and a section with problems and solutions as well as new case studies have been added. Following an introduction to the history of enzyme applications, the text goes on to cover in depth enzyme mechanisms and kinetics, production, recovery, characterization and design by protein engineering. The authors treat a broad range of applications of soluble and immobilized biocatalysts, including wholecell systems, the use of non-aqueous reaction systems, applications in organic synthesis, bioreactor design and reaction engineering. Methods to estimate the sustainability, important internet resources and their evaluation, and legislation concerning the use of biocatalysts are also covered.

Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science
Author : Dr. Inamuddin,Rajender Boddula,Abdullah M. Asiri
Publisher : Elsevier
Release Date : 2020-06-19
Category : Technology & Engineering
Total pages :382
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Green Sustainable Process for Chemical and Environmental Engineering and Science: Sonochemical Organic Synthesis focuses on purification and extraction of organic, biological, and medicinal compounds using sonochemistry. It provides readers with an understanding of green ultrasound-assisted chemical synthesis for industrial applications. This book systematically explores the application of ultrasound in organic synthesis of all types and includes stereoselectivity, regioselectivity, oxidations, reductions, protection, deprotection, additions, condensation, coupling, C-X bond formation, named reactions, heterocyclics, biological drugs, and fluoroorganics over conventional techniques. A brief introduction to the parameters which influence the process, solvent-effects, supported reagents and catalysis and the pros and cons to the practical use of sonochemical protocols in organic synthesis are also discussed. This book provides overview on the applications of sonochemical technology for the sustainable and environmentally friendly development of synthetic methodologies for organic and pharmaceutical chemistry. Sonochemical Organic Synthesis is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in modern organic chemistry and medicinal chemistry. Offers a broad overview of ultrasonics-assisted green organic synthesis Discusses sonochemical technology for green organic synthesis and biological medicinal importance Gives detailed accounts of numerous industrial applications, including polymers, pharmaceutical, fluoroorganics, biofuel, carbon, and more Includes a description of significant factors and challenges in ultrasonics-assisted green organic synthesis Lists recent developments in the use of sonochemical technology in organic chemist

Science of Synthesis: Biocatalysis in organic synthesis

Science of Synthesis: Biocatalysis in organic synthesis
Author : Kurt Faber,Wolf-Dieter Fessner,Nicholas Turner
Publisher : Unknown
Release Date : 2015
Category : Biocatalysis
Total pages :712
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The three Science of Synthesis volumes on Biocatalysis in Organic Synthesis present a broad contemporary overview on the state-of-the-art in enzymatic methods for asymmetric synthesis suitable for academics and industrial researchers working in the field of organic synthesis. The goal is to start a new wave of enthusiasm for biocatalysis in the broader community and to give an overview of the field. Biocatalysis in Organic Synthesis offers critical reviews of organic transformations by experts, including experimental procedures. The organization is based on the type of reaction performed under biocatalysis. Volume 3 begins with oxidation. A chapter on enzyme-catalyzed dihydroxylation is followed by reviews of alkane oxidation. Oxidations of alcohols, carbonyl compounds, and heteroatoms are covered, as are halogenations. The use of biocatalysts in total synthesis, cascade reactions, and large-scale industrial applications is considered. Finally, emerging trends are discussed.

Biocatalysis in the Pharmaceutical and Biotechnology Industries

Biocatalysis in the Pharmaceutical and Biotechnology Industries
Author : Ramesh N. Patel
Publisher : CRC Press
Release Date : 2006-09-26
Category : Science
Total pages :893
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Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications. Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening. Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.