November 29, 2020

Download Ebook Free Overcoming Cancers Resistant To HER-2 Antibodies

Resistance to Immunotherapeutic Antibodies in Cancer

Resistance to Immunotherapeutic Antibodies in Cancer
Author : Benjamin Bonavida
Publisher : Springer Science & Business Media
Release Date : 2013-08-04
Category : Medical
Total pages :202
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​​​​The traditional approaches to treat various cancers include chemotherapy, radiation and/or hormonal therapy. While these therapies continue to be effective in large part, they are not selective and highly toxic. There have been encouraging results in alternative therapeutic approach called antibody-mediated anti-cancer therapy, which is less toxic, more selective, and can also reverse drug/radiation resistance. Monoclonal antibodies or mAbs can be used to destroy malignant tumor cells and prevent tumor growth by blocking specific cell receptors. mAbs can bind only to cancer cell-specific antigens and induce an immunological response against the target cancer cell. The book covers the common and unique features of mAbs agains various cancer, gives the latest developments on the molecular, biochemical and genetic mechanisms of resistance by various mAbs, as well as discuss novel mAbs to overcome resistance.

Cancer Chemotherapy and Biotherapy

Cancer Chemotherapy and Biotherapy
Author : Bruce A. Chabner,Dan L. Longo
Publisher : Lippincott Williams & Wilkins
Release Date : 2011-12-07
Category : Medical
Total pages :848
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Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.

Targeted Cancer Therapies, From Small Molecules to Antibodies

Targeted Cancer Therapies, From Small Molecules to Antibodies
Author : Zhe-Sheng Chen,Jian-ye Zhang,Yunkai Zhang,Yan-yan Yan
Publisher : Frontiers Media SA
Release Date : 2020-07-22
Category :
Total pages :129
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Nanostructures for Cancer Therapy

Nanostructures for Cancer Therapy
Author : Alexandru Mihai Grumezescu,Anton Ficai
Publisher : Elsevier
Release Date : 2017-04-11
Category : Technology & Engineering
Total pages :920
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Nanostructures for Cancer Therapy discusses the available preclinical and clinical nanoparticle technology platforms and their impact on cancer therapy, including current trends and developments in the use of nanostructured materials in chemotherapy and chemotherapeutics. In particular, coverage is given to the applications of gold nanoparticles and quantum dots in cancer therapies. In addition to the multifunctional nanomaterials involved in the treatment of cancer, other topics covered include nanocomposites that can target tumoral cells and the release of antitumoral therapeutic agents. The book is an up-to-date overview that covers the inorganic and organic nanostructures involved in the diagnostics and treatment of cancer. Provides an examination of nanoparticle delivery systems for cancer treatment, illustrating how the use of nanotechnology can help provide more effective chemotherapeutic treatments Examines, in detail, the different types of nanomaterials used in cancer therapy, also explaining the effect of each Provides a cogent overview of recent developments in the use of nanostructured materials in chemotherapeutics, allowing readers to quickly familiarize themselves with this area

Breast Cancer Chemosensitivity

Breast Cancer Chemosensitivity
Author : Dihua Yu,Mien-Chie Hung
Publisher : Springer Science & Business Media
Release Date : 2009-12-30
Category : Medical
Total pages :175
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In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem, the book then focuses on the latest findings of molecular mechanisms of drug resistance. Coverage provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment. It allows those who are interested in breast cancer therapy to get a jump-start on critical issues in breast cancer therapeutic resistance.

Targeted Therapies in Breast Cancer

Targeted Therapies in Breast Cancer
Author : George W. Sledge, Jr.,Jose Baselga
Publisher : Unknown
Release Date : 2013-04-15
Category : Medical
Total pages :100
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This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

Anticancer Research

Anticancer Research
Author : Anonim
Publisher : Unknown
Release Date : 2007
Category : Cancer
Total pages :129
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Adjuvant Therapy for Breast Cancer

Adjuvant Therapy for Breast Cancer
Author : Monica Castiglione,Martine J. Piccart
Publisher : Springer Science & Business Media
Release Date : 2009-07-11
Category : Medical
Total pages :490
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Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.

Advances in Cancer Research

Advances in Cancer Research
Author : George F. Vande Woude,George Klein
Publisher : Academic Press
Release Date : 2009-10-22
Category : Science
Total pages :160
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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including nitric oxide-induced apoptosis in tumor cells, detection of minimal residual disease, immunity to oncogenetic human papillomavirus, and modeling prostate cancer in the mouse.

Difficult Diagnoses in Breast Pathology

Difficult Diagnoses in Breast Pathology
Author : Juan P. Palazzo, MD
Publisher : Demos Medical Publishing
Release Date : 2011-06-22
Category : Medical
Total pages :264
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Breast cancer is the second leading cause of cancer death in women in the United States. For the pathologist, almost any breast lesion may produce diagnostic difficulty, especially due to frequently small samples (core biopsy specimens) and a variety of mimics and variants seen in specific types of lesions. Additionally, the difficulty of breast lesion diagnosis has risen dramatically in recent years due to the increased emphasis on stratifying patients for appropriate therapy on an individual basis; the wider range of both local and systemic therapeutic options, and the potential for earlier diagnosis through increased mammographic breast screening leading to a higher likelihood of a favorable outcome. Difficult Diagnoses in Breast Pathology provides a highly visual presentation of the major problems and questions that a pathologist is likely to encounter in the evaluation of common and uncommon breast diseases. Coverage includes needle core biopsy interpretation, diagnosis of precursor lesions, early stage disease, and recognition of neoplastic mimics and other misleading variants. In addition, this book emphasizes particularly difficult areas including the use of newer immunohistochemical markers. Throughout, the emphasis is on an easily accessible presentation with tables and lists of key points summarizing major findings and numerous high-quality images supporting the text. Difficult Diagnoses in Breast Pathology will be a valuable reference for every pathologist who deals with the diagnosis of breast diseases. Difficult Diagnoses in Breast Pathology Features: Each chapter authored by recognized expert in the area Hundreds of high-quality images Tables and key points in each chapter summarize the most important findings Coverage based on addressing in detail the real-world diagnostic problems the pathologist will face in daily practice

Breast Cancer Management

Breast Cancer Management
Author : Lynda R. Wiseman
Publisher : Lippincott Williams & Wilkins
Release Date : 2000
Category : Medical
Total pages :133
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Cancer Research

Cancer Research
Author : Anonim
Publisher : Unknown
Release Date : 2009-11
Category : Cancer
Total pages :129
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Oncology

Oncology
Author : Anonim
Publisher : Unknown
Release Date : 2006
Category : Oncology
Total pages :129
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Recent Developments in Monoclonal Antibody Therapy for Breast Cancer

Recent Developments in Monoclonal Antibody Therapy for Breast Cancer
Author : Brittany Jiang
Publisher : Unknown
Release Date : 2008
Category :
Total pages :56
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Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition

Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition
Author : Laurence Brunton,Bjorn Knollman,Randa Hilal-Dandan
Publisher : McGraw Hill Professional
Release Date : 2017-10-26
Category : Medical
Total pages :1808
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The gold-standard of pharmacology texts – completely updated to reflect the latest research and developments A Doody’s Core Title for 2019! Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Thirteenth Edition represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. The Thirteenth Edition includes more than 500 color illustrations, with many new figures emphasizing mechanisms of drug action. More than 30 new contributors have added to this edition, while the focus on basic principles is undiminished. This edition is enhanced by timely new content: •NEW chapters including Treatment of Pulmonary Arterial Hypertension, Immunity and Inflammation, Immunoglobulins and Vaccines, and Treatment of Viral Hepatitis •Expanded coverage of cardiovascular disease, with separate chapters on myocardial ischemia, hypertension, and heart failure •Increased emphasis on cellular signaling pathways involved in drug action •Summary tables at the end of each chapter that organize drugs discussed in that chapter into relevant categories and detail therapeutic usage, clinical pharmacology, and tips •Chapter Content Outlines at the beginning of each chapter •Abbreviation boxes in every chapter to easily identify the abbreviations appearing in that chapter More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice.