June 17, 2021

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Perinatal Stem Cells

Perinatal Stem Cells
Author : Zhong Chao Han,Tsuneo A. Takahashi,Zhibo Han,Zongjin Li
Publisher : Springer
Release Date : 2019-04-06
Category : Health & Fitness
Total pages :173
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This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury. Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton’s Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.

Perinatal Stem Cells

Perinatal Stem Cells
Author : Anthony Atala,Sean V. Murphy
Publisher : Springer
Release Date : 2014-08-28
Category : Science
Total pages :373
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This comprehensive volume is one of the first books to offer the reader detailed insight into sources of perinatal stem cells, their biology, and their potential for disease treatment. It examines the research and therapeutic applications of perinatal stem cells including the treatment of renal disease, hematopoietic regeneration, cardiac disease, inflammatory disease, bone regeneration, pulmonary disease, and the treatment of spinal cord injury. Further, the book discusses current progress in the manufacturing, banking and clinical translation of perinatal stem cells. Through this book, readers will gain a thorough understanding of the current pre-clinical and clinical applications of perinatal stem cells as well as the efforts to support the transition of perinatal stem cell therapies from laboratories to clinics. Perinatal Stem Cells contains thirty-two chapters written by internationally recognized leaders in stem cell research. It is organized into four sections covering amniotic fluid stem cells, placental and placental membrane stem cells, umbilical cord stem cells, and clinical translation. This cohesive structure provides an effective framework for detailed insight into this new frontier. Edited by Dr. Anthony Atala, one of the foremost experts in the field, and his co-editor Dr. Sean V. Murphy, this volume is a definitive work for stem cell research and its future implications. It is a key resource for all stem cell researchers, clinicians, and government and industry staff working in this dynamic and exciting field.

Perinatal Stem Cells

Perinatal Stem Cells
Author : Anthony Atala,Kyle J. Cetrulo,Rouzbeh R. Taghizadeh,Curtis L Cetrulo,Sean Murphy
Publisher : Academic Press
Release Date : 2018-06-14
Category : Science
Total pages :418
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Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells

Perinatal Tissue-Derived Stem Cells

Perinatal Tissue-Derived Stem Cells
Author : Babak Arjmand
Publisher : Springer
Release Date : 2016-12-01
Category : Science
Total pages :239
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This book covers several aspects of perinatal tissue-derived stem cells, from theoretical concepts to clinical applications. Topics include functions and different sources, immunomodulatory properties, translational point of view, GMP facility design and manufacturing for clinical translation, therapeutic potentials, and finally ethical considerations. The text provides a brief review of each type of perinatal stem cells and then focuses on their multi- or pluripotent properties, regenerative capacity, and future therapeutic potential in regenerative medicine. Additionally, the book discusses GMP compliance in stem cell facilities and the manufacture of stem cells for clinical translation. The chapters are authored by world-renowned experts in the perinatal stem cell field. Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for basic and clinical scientists, clinicians, and pharmaceutical experts working or conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, and cellular therapy.

Fetal Stem Cells in Regenerative Medicine

Fetal Stem Cells in Regenerative Medicine
Author : Dario O. Fauza,Mahmud Bani
Publisher : Springer
Release Date : 2016-05-02
Category : Science
Total pages :453
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This book explores the regenerative properties of fetal stem cells, from feto-maternal cell traffic through perinatal stem cells, with a discussion of key topics including stem cell banking, drug screening, in utero stem cell transplantation and ethical considerations. The expertly authored chapters also delve into embryonic, amniotic membrane, and umbilical cord blood stem cells; fetal development models; fetal cell reprogramming; culture methods; disease models; perinatal gene therapy, and more. These chapters are grouped into four sections, each discussing a separate prenatal stem cell population and providing fascinating historical contexts for our knowledge of these systems. Featuring a foreword written by the renowned Dr. Joseph Vacanti of the Harvard Stem Cell Institute, Fetal Stem Cells in Regenerative Medicine: Principles and Translational Strategies is a welcome and timely contribution to the Stem Cell Biology and Regenerative Medicine series. It is essential reading for scientists and researchers, clinicians and residents, and advanced students involved in stem cells, regenerative medicine, tissue engineering, and related disciplines such as embryology.

Perinatal Stem Cells

Perinatal Stem Cells
Author : Anthony Atala,Kyle J. Cetrulo,Rouzbeh R. Taghizadeh,Sean Murphy,Curtis L. Cetrulo
Publisher : Academic Press
Release Date : 2018-06
Category : Medical
Total pages :354
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Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton's jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells

Umbilical Cord Blood Hematopoietic Stem Cells

Umbilical Cord Blood Hematopoietic Stem Cells
Author : Daniel Viktor Surbek
Publisher : Unknown
Release Date : 2000
Category :
Total pages :40
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Cell Therapy for Perinatal Brain Injury

Cell Therapy for Perinatal Brain Injury
Author : Haruo Shintaku,Akira Oka,Makoto Nabetani
Publisher : Springer
Release Date : 2018-03-01
Category : Medical
Total pages :150
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This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.

Perinatal Stem Cells

Perinatal Stem Cells
Author : Kyle Cetrulo,Curtis L. Cetrulo, Jr.,Rouzbeh R. Taghizadeh
Publisher : John Wiley & Sons
Release Date : 2013-02-04
Category : Science
Total pages :320
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Perinatal Stem Cells, 2nd Edition builds on the firstedition to provide an updated tutorial on perinatal stem cells,including stem cells harvested from the amniotic fluid, placenta,maternal blood supply, umbilical cord and Wharton's Jelly. As inthe first edition, coverage includes the underlying biology of eachof the sources of pregnancy related stem cells, cell culture, andpotential therapeutic uses, as well as insights on the impact ofthese stem cells from obstetricians and gynecologists,cardiologists, hematologists, tissue engineers, and cord bloodbankers. Normally discarded as medical waste, perinatal stem cells offera powerful therapeutic tool box alternative to the controversialembryonic stem cells. Since publication of the first edition, aburgeoning commerical industry has developed around various sourcesof perinatal cells, and the second edition now includes an overviewof this growing industry. With contributions from some of the top academic stem celllaboratories in the United States as well as new chapters frominternational stem cell scientists, Perinatal StemCells presents an update onthe cutting-edge research in the field whilemaintaining its signature clinical focus.

Homing of Placental-derived Mesenchymal Stem Cells After Perinatal Intracerebral Transplantation in a Rat Model

Homing of Placental-derived Mesenchymal Stem Cells After Perinatal Intracerebral Transplantation in a Rat Model
Author : Martin Müller
Publisher : Unknown
Release Date : 2011
Category :
Total pages :42
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Isolation, Characterization and Therapeutic Feasibility of Human Umbilical Cord Derived Stem Cells

Isolation, Characterization and Therapeutic Feasibility of Human Umbilical Cord Derived Stem Cells
Author : Anonim
Publisher : Unknown
Release Date : 2017
Category : Cellular therapy
Total pages :478
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Because of recent advances in stem cell research, cell therapies have gained increasing attention. Stem cells have shown promise to treat degenerative diseases and disorders such as Parkinson's disease, Alzheimer's disease, multiple sclerosis and degenerative disc disease. They are also being investigated to repair and regenerate skeletal tissues and structures. Pluripotent embryonic stem cells (ESCs) have the ability to differentiate into all of 200 types of cell in human body and have greatest potential for cell therapy. However, they face ethical and moral concerns. Whereas, adult stem cells (ASCs) such as bone marrow stromal cells (MSCs), hematopoietic stem cells (HSCs) are more acceptable for cell but they display limited proliferation and differentiation potential. Furthermore, ASCs may undergo genetic changes due to aging and environmental stress. Therefore, others and we have searched for alternative sources of cells for therapeutic usage. These efforts have led to discover stem cells (SCs) from perinatal tissues such as human umbilical blood and cord (UC). Not only, the SCs isolated from perinatal sources can be isolated non-invasively but also they are more primitive than ASCs. Current methods to isolate SCs from UC yield low amounts of cells with variable proliferation potential. Since, UC is an anatomically complex organ; we hypothesized that the variation in the SCs could be due to the difference in the various niches the UC harboring the SCs. In this study, we dissected the UC into its discrete parts, cord lining (CL), Wharton's jelly (WJ) and cord placenta junction (CPJ) and isolated SCs from each of these segments using explant culture technique. The isolated cells from all three sources displayed adherent fibroblastoid morphology, and not only expressed MSCs markers, CD29, CD44, CD73, CD90, and CD105 but also pluripotency genes, OCT4, NANOG, SOX2 and KLF4. They differentiated into multiple lineages such as adipogenic, chondrogenic and osteogenic cells. However, these cells displayed variations in their clonal capacity, ability to self-renew and differentiate depending upon the source of their isolation. SCs isolated from CPJ had highest rate of proliferation and greater capacity to self-renew and differentiate as compared to the SCs derived from CT and WJ. Microarray analysis confirmed the differences in these SCs based on the findings of differentially expressed genes between CPJ-, CL- and WJ-MSCs. We also found variation in the expression of IncRNA genes. Our studies demonstrated CJP as the sources of SCs with superior properties. These cells were then used for cell therapy and toxicological studies. Cell therapy feasability studies were conducted using CPJ-SCs and their chondrogenic derivatives, chondroprogenitor cells (CPCs) and nucleus pulposus (NP) like cells (NPCs) to regenerate damaged intervertebral disc (IVD) in a rabbit model. Degeneration of IVD results due to the loss of NP and is a common cause of lower back pain. Animal studies performed by transplanting CPJ-SCs and their derivatives showed significant improvement in the histology, cellularity, extracellular matrix proteins, and water and glycosaminoglycan contents of IVDs. Furthermore, the transplanted cells survived, engrafted and displayed homing into NP in situ. In addition, IVDs receiving CPJ-SCs derivatives exhibited higher expression of NP specific human markers, SOX9, ACAN, COL2, FOXF1, and KRT19. The regulation of the regeneration process and the NP biosynthesis was determined to be via TGF[beta]1/Smad pathway. Overall, the animal study showed that NPCs were is more efficacious than the CPCs and SCs. Our results provide basis and impetus for clinical studies to treat DDD as well as other degenerative diseases and disorders. Furthermore, these cells could be used for tissue engineering, regenerative medicine and pharmaceutical applications.

Placenta

Placenta
Author : Taylor & Francis Group
Publisher : CRC Press
Release Date : 2021-03-30
Category :
Total pages :296
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Long regarded as biological waste, the placenta is gaining momentum as a viable product for clinical use. Due to their unique properties, placental cells and derivatives show great promise in curing various diseases. Utilizing contributions from world-renowned experts, Placenta: The Tree of Life considers the therapeutic potential of these cells. It examines new stem cell-based strategies and highlights recent studies that advance the range of treatment for a number of illnesses. Emphasizing the potential research and therapeutic use of stem cells, the book discusses the development, structure, and functions of the human placenta. It introduces overall aspects of the immune system, explains some of the immune mechanisms during pregnancy, and shows the role of the placenta in these mechanisms. Current scientific research is presented that focuses on the mechanisms of action underlying the therapeutic benefit of cells isolated from different placental regions. An exhaustive examination, this pivotal work: Considers how perinatal cells may represent an important source for cell therapy approaches in the near future, in both human and veterinary medicine Describes the clinical potential of placenta-derived cells in regenerative medicine--specifically in neurological disorders, metabolic liver diseases, inflammatory diseases, and autoimmune diseases Explains how cells isolated from different placental tissues share basic properties Placenta: The Tree of Life summarizes the advantages of perinatal tissue as a source of cells with therapeutic potential and is designed for use in the study of genetics, stem cell science, placental function, reproductive biology, regenerative medicine, and related fields.

The Effects of Perinatal Hypoxia/ischemia on the Stem Cells and Progenitor Cells of the SVZ[subscript]DL in Vivo

The Effects of Perinatal Hypoxia/ischemia on the Stem Cells and Progenitor Cells of the SVZ[subscript]DL in Vivo
Author : Michael J. Romanko
Publisher : Unknown
Release Date : 2004
Category :
Total pages :129
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A Regenerative Response of Endogenous Neural Stem Cells to Perinatal Hypoxic/ischemic Brain Damage

A Regenerative Response of Endogenous Neural Stem Cells to Perinatal Hypoxic/ischemic Brain Damage
Author : Ryan J. Felling
Publisher : Unknown
Release Date : 2006
Category :
Total pages :129
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Modelling Perinatal Stroke and Stem Cell Grafting in a Neonatal Rat

Modelling Perinatal Stroke and Stem Cell Grafting in a Neonatal Rat
Author : Reem Mohammed A. Basuodan
Publisher : Unknown
Release Date : 2018
Category :
Total pages :129
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