December 1, 2020

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Peripheral Nerve Disorders

Peripheral Nerve Disorders
Author : Jean-Michel Vallat,Joachim Weis
Publisher : John Wiley & Sons
Release Date : 2014-10-20
Category : Medical
Total pages :320
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Peripheral Nerve Disorders: Pathology and Genetics is adefinitive, clinically-oriented guide to the pathology ofperipheral nerve disorders. These commonly seen neurological challenges have many causes andaccurate diagnosis is often necessary via pathological analysis.New techniques exploiting molecular biological knowledge haveopened up new vistas to understanding the pathogenesis of thesedisorders, and hence their effective management. This new title takes a disease-oriented approach to understandingthe pathology of these conditions. It combines classical andcontemporary techniques to enable practitioners in neurology andneuropathology to better understanding of the disease processesunderlying patients? presentations and to formulateappropriate management plans. Peripheral Nerve Disorders: Pathology and Genetics is avaluable resource for neurologists, neuropathologists,pathologists, neurobiologists and geneticists.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
Author : W. Grisold,Chiara Briani,Andrea Vass
Publisher : Elsevier Inc. Chapters
Release Date : 2013-08-17
Category : Medical
Total pages :1008
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The peripheral nervous system can be affected by malignancies involving different mechanisms. Neoplastic nerve lesion by compression, invasion, and infiltration is rare and occurs in particular in leukemia (neuroleukemiosis) and lymphoma (neurolymphomatosis). Its occurrence is much rarer in cancer, and even less so in sarcoma. The neoplastic infiltration of peripheral nerves by solid tumors is characterized by specific topographical sites such as the base of the skull, the ear, nose and throat region, and the cervico-brachial plexus as well as the lumbar and sacral plexus. Rarely malignant invasion affects the cranial nerves of the face where it can spread centripetally. Autonomic nerves and ganglia can also be affected. The retrograde spread of cancer in nerves is a bad prognostic sign. The clinical diagnosis is determined by tumor type, the pattern of involvement, and often pain.

Peripheral Nerve Disorders and Treatment

Peripheral Nerve Disorders and Treatment
Author : Hande Turker,Leonel Garcia Benavides,Guillermo Ramos Gallardo,Miriam Méndez Del Villar
Publisher : BoD – Books on Demand
Release Date : 2020-07-08
Category : Medical
Total pages :192
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Neuropathies are one of the main neurological problems in everyday life, and they still have many partially understood parts and unknowns both for physicians and patients. Many systemic conditions may exist within them and therefore they may be difficult to treat. In this book we provide current knowledge concerning neuropathies, which we believe you will find interesting. The subject ‘’neuropathies’’ comprises a number of topics, and each and every one could be the subject of a textbook. On the other hand, this book was never designed as one. This book should be read without prejudgment because the content may not be compatible with general but repeated assumptions and guidelines. However, I believe that the book may be an inspiration for many young investigators as well. It contains current approaches and knowledge and we sincerely believe and hope that it will answer your queries regarding new perspectives about neuropathy in general.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
Author : Matthew C. Kiernan,Ryuji Kaji
Publisher : Elsevier Inc. Chapters
Release Date : 2013-08-17
Category : Medical
Total pages :1008
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The chief role of the axon is that of impulse conduction, which depends on the electrical cable structure and voltage-dependent ion channels of the axonal membrane. Over recent decades, the development of specialized techniques such as patch clamping and site-directed mutagenesis have established the contribution of neuronal ion channel function to the processes of impulse conduction in myelinated nerves. Recently, these insights from in vitro studies have been translated into the clinical realm. In keeping with this progress, clinical axonal excitability techniques have been developed to provide information related to the activity of a variety of ion channels, energy-dependent pumps, and ion exchange processes activated during impulse conduction in peripheral axons. These noninvasive techniques have been extensively applied to the study of the biophysical properties of human peripheral nerves in vivo and have provided important insights into axonal ion channel function in health and neurological disease, particularly in relation to the pathophysiological mechanisms that underlie neuropathy.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
Author : Osvaldo J.M. Nascimento,Wilson Marques
Publisher : Elsevier Inc. Chapters
Release Date : 2013-08-17
Category : Medical
Total pages :1008
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Symptomatic peripheral neuropathy occurs in a small proportion of HTLV-1 infected patients. Peripheral manifestations are often masked by symptoms and signs of the tropical spastic myelopathy characteristic of the disease. Peripheral neuropathy is often characterized by alteration of small-fiber functions, with inflammatory lesions of peripheral nerves, sometimes associated with symptomatic polymyositis, which may occur in isolation in this setting.

Basic Principles of Peripheral Nerve Disorders

Basic Principles of Peripheral Nerve Disorders
Author : Seyed Mansoor Rayegani
Publisher : BoD – Books on Demand
Release Date : 2012-03-28
Category : Medical
Total pages :290
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Peripheral nerve disorders are comprising one of the major clinical topics in neuromusculoskeletal disorders. Sharp nerve injuries, chronic entrapment syndromes, and peripheral neuropathic processes can be classified in this common medical topic. Different aspects of these disorders including anatomy, physiology, pathophysiology, injury mechanisms, and different diagnostic and management methods need to be addressed when discussing this topic. The goal of preparing this book was to gather such pertinent chapters to cover these aspects.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
Author : V. Planté-Bordeneuve,P. Kerschen
Publisher : Elsevier Inc. Chapters
Release Date : 2013-08-17
Category : Medical
Total pages :1008
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TTR FAP is characterized by phenotypic and genotypic heterogeneity. The severity of polyneuropathy along with autonomic dysfunction and heart involvement makes it a life-threatening disease. This protein is mainly produced by the liver. Molecular genetic testing is essential in the diagnostic strategy. TTR-Val30Met is the most frequent substitution, resulting in a guanine to cytosine mutation in exon 2 of the gene. It is virtually the only variant detected in Portugal, Brazil, and Sweden. By contrast, as many as 30 different TTR variants are reported in Japan and in other European countries. A less severe phenotype with late onset has been reported. Diagnosis should be performed as early as possible since upcoming pharmacological therapeutic approaches are now available, in addition to liver transplantation.

Peripheral Neuropathies in Clinical Practice

Peripheral Neuropathies in Clinical Practice
Author : Steven Herskovitz,Stephen Scelsa,Herbert Schaumburg
Publisher : OUP USA
Release Date : 2010-02-11
Category : Medical
Total pages :382
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"Peripheral Neuropathies in Clinical Practice is a revamped and updated version of Disorders of Peripheral Nerves, published in 1992. The current edition begins with basic concepts and anatomic classifications of the Peripheral Nervous System (PNS) and its disorders." "The anatomic complexities, varied presentations, and innumerable etiologies of peripheral neuropathies present substantial challenges for the practicing clinician. Comprehensive and concise in approach, Peripheral Neuropathies in Clinical Practice is a thorough review of the neurologic literature written by expert clinicians, each of whom are leaders in the field. Its aim is to assist neurologists, trainees in neurology and related fields, and all practitioners who see these patients to better understand, evaluate, and manage peripheral nerve disorders."--BOOK JACKET.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
Author : Ximena Arcila-Londono,Richard A. Lewis
Publisher : Elsevier Inc. Chapters
Release Date : 2013-08-17
Category : Medical
Total pages :1008
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Multifocal motor neuropathy (MMN) is a rare disorder in which the symptoms are caused by persistent conduction block lesions. The mononeuropathy multiplex progresses over time with increasing axonal loss. The cause of the conduction blocks and axonal loss are not completely understood but immune mechanisms are involved and response to intravenous immunoglobulin has been established. The importance of MMN goes beyond its clinical incidence as the increasing understanding of the pathogenesis of this disorder has implications for other peripheral nerve diseases and for our knowledge of peripheral nerve biology.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
Author : Hadi Manji
Publisher : Elsevier Inc. Chapters
Release Date : 2013-08-17
Category : Medical
Total pages :1008
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Although drug-induced neuropathies account for only 2–4% of referrals, their identification is important. Numerically, chemotherapy and antiretroviral drugs are the most important worldwide. Research is currently focused on elucidating pathogenic mechanisms and the earliest presymptomatic changes using neurophysiological and pharmacogenetic techniques in order to avoid the drug or make dosage changes before irreversible damage occurs. Chemoprotectants against chemotherapy-induced neuropathy are also an active area of research. This chapter focuses on the pathophysiology of drug-induced neuropathies in general, followed by detailed reviews of neuropathy due to; newer compounds such as TNF (tumor necrosis factor) α antagonists and antibiotics such as linezolid; chemotherapeutic agents, old and new, where significant progress has been made; antiretroviral drugs; and amiodarone, which is unusual in that it causes a demyelinating neuropathy. The controversial issue of statin-induced neuropathy is also reviewed.

Diagnosis and Management of Peripheral Nerve Disorders

Diagnosis and Management of Peripheral Nerve Disorders
Author : Jerry R. Mendell,David R. Cornblath,John T. Kissel
Publisher : Oxford University Press
Release Date : 2001-03-08
Category : Medical
Total pages :695
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Peripheral neuropathies represent a challenging subject for most physicians. This is an up-to-date, comprehensive, and readable book on peripheral neuropathies that includes concise information on the clinical, electrophysiological, pathological, pathogenic, and treatment aspects of the most important disorders. New molecular and serologic diagnostic tests are discussed. Sections are devoted to nerve and skin biopsy techniques and findings, quantitative sensory and autonomic reflex tests. Case examples are used liberally throughout the text. The editors: Mendell, Kissel, and Cornblath are experienced clinicians that bring complementary knowledge to each of the subjects. Additional authors have been handpicked for specific topics which add to the value of the edition.

Textbook of Peripheral Neuropathy

Textbook of Peripheral Neuropathy
Author : Peter D. Donofrio, MD
Publisher : Demos Medical Publishing
Release Date : 2012-04-17
Category : Medical
Total pages :486
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Textbook of Peripheral Neuropathy is a practical but authoritative reference for clinicians in anymedical specialty who are evaluating and treating patients with signs and symptoms of a peripheralneuropathy. Reviewing the full spectrum of clinically significant neuropathies, the book contains chapterson common and rare forms including mononeuropathy in the upper and lower extremities, mononeuritismultiplex, diffuse and symmetric polyneuropathies, brachial and lumbrosacral plexopathies, and spinalroot disordersódisorders that can mimic diffuse and/or focal neuropathies, complicating diagnosis andevaluation. Coverage encompasses both inherited and acquired diseases, including neuropathies arisingfrom physical injury, diabetes, alcoholism, toxins, autoimmune responses, nutritional deficiencies, vascularand metabolic disorders, medication-induced neuropathies, and idiopathic conditions. The textbookprovides an evidence-based approach to testing, differential diagnosis, and treatment, and should serveas a trusted resource for healthcare professionals confronting the many manifestations of peripheralneuropathy in clinical practice. The chapters are written by internationally renowned expert contributors with deep clinical experienceand contain numerous tables, figures, and algorithms providing clear diagnostic and managementguidelines. Boxed Clinical Pearls and Key Points allow for quick access to pertinent information, making evaluation and review easy and rewarding. Features of Textbook of Peripheral Neuropathy Include: ̈ Practical yet comprehensiveóan accessible ìgo-toî reference for clinicians ̈ Covers all clinically relevant peripheral neuropathies ̈ Clinical Pearls and Key Points are set off from the text for quick reference ̈ Contains clear diagnostic and management guidelines from expert contributors ̈ Structured chapters make it easy to find essential point-of-careinformation

High-Resolution Ultrasonography for Peripheral Nerve Diagnostics

High-Resolution Ultrasonography for Peripheral Nerve Diagnostics
Author : Einar P. Wilder-Smith
Publisher : World Scientific
Release Date : 2010
Category : Medical
Total pages :72
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The past 10 years have seen the explosive expansion of the field of high-resolution imaging of the peripheral nervous system because of technical advances in sonography, allowing for good resolution, rapid imaging and (relatively) inexpensive images of the peripheral nervous structures. This timely volume presents the rapid advances and clinical relevance of high-resolution sonography for peripheral nerve diagnostics in a precise and clinically relevant way. The book begins by describing the characteristics of normal and diseased peripheral nerves, and then discusses the value of sonography in common conditions, with the help of clear and easy-to-understand illustrations to explain how to proceed to identify structures. The topics covered include common entrapment neuropathies (carpal tunnel syndrome, ulnar neuropathy, radial neuropathy, peroneal neuropathy) and other conditions in which sonography can play a role in diagnosis, such as CIPD, motor neuropathy with multiple conduction blocks, leprosy, and brachial plexus disorders. High-Resolution Ultrasonography for Peripheral Nerve Diagnostics is an essential guide for those involved in the diagnostic work-up of peripheral nerve disorders. It gives a precise and practical overview of this rapidly emerging field whilst maintaining a practical bent. Clinical neurophysiologists, neurologists, orthopedic surgeons, hand surgeons and rehabilitation medicine specialists will all benefit from having this book. Sample Chapter(s). Chapter 1: Introduction (208 KB). Contents: Introduction; Finding the Nerve; Clinical Applications. Readership: Neurologists, clinical neurophysiologists, orthopedic surgeons, hand surgeons, rehabilitation medicine specialists.

Peripheral Nerve Disorders

Peripheral Nerve Disorders
Author : Gérard Said,Christian Krarup
Publisher : Elsevier
Release Date : 2013-08-17
Category : Medical
Total pages :1008
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Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities. Covers both hereditary and cryptogenic neurologic disorders Includes advances in the basic science of PNS from molecular genetics, biochemistry, immunology, morphology and physiology Detailed coverage of neuropathy in connective tissue disorders, infectious disorders, metabolic disorders and malignancy

Peripheral Nerve Disorders

Peripheral Nerve Disorders
Author : Gérard Said,Christian Krarup
Publisher : Elsevier
Release Date : 2013-08-17
Category : Medical
Total pages :1008
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Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities. Covers both hereditary and cryptogenic neurologic disorders Includes advances in the basic science of PNS from molecular genetics, biochemistry, immunology, morphology and physiology Detailed coverage of neuropathy in connective tissue disorders, infectious disorders, metabolic disorders and malignancy