June 20, 2021

Download Ebook Free Precision Medicine For Autoimmune Diseases

Precision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence
Author : Michael Mahler
Publisher : Academic Press
Release Date : 2021-04-01
Category : Science
Total pages :300
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Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on AI, its link to PM, and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as artificial intelligence (AI) has gained significant attention in the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems has enabled the generation of large amounts of data, making autoimmunity an ideal target for AI in the field of Precision Medicine (PM). More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large data sets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to get a good overview of the field of Precision Medicine for autoimmune diseases and Artificial Intelligence Provides background, milestone and examples of precision medicine for autoimmune disease and artificial intelligence Proves the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using artificial intelligence

Precision Medicine for Autoimmune Diseases

Precision Medicine for Autoimmune Diseases
Author : Georg Lautscham
Publisher : Academic Press
Release Date : 2020-09
Category :
Total pages :366
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Autoimmune diseases have significant economic and social impacts and represent the second-most important market for pharmaceutical companies, which is unsurprising when you consider that, while 1 in 33 American will suffer from cancer, 1 in 22 Americans will suffer from an autoimmune disease, costing the US over $ 100 billion a year. However, the uptake of precision medicine in this area has been slow at best, even though it can be extremely difficult to accurately diagnose and treat patients effectively using the tools that are currently available. If the adoption of precision medicine is to truly gather pace among diseases outside of cancer, there are still several regulatory, technological, and funding-related hurdles to be overcome. Taking lessons learned from within the field of oncology and systematically applying them to areas such as autoimmune disease will enable the development of more effective drugs across a wider range of illnesses. Most importantly, this will lead to a better outcome for patients. Precision Medicine for Autoimmune Diseases summarizes the status, the ongoing activities and provides an outlook to the future.

Epigenetics in Allergy and Autoimmunity

Epigenetics in Allergy and Autoimmunity
Author : Christopher Chang,Qianjin Lu
Publisher : Springer
Release Date : 2021-05-23
Category : Medical
Total pages :403
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This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

Epigenetics in Allergy and Autoimmunity

Epigenetics in Allergy and Autoimmunity
Author : Christopher Chang,Qianjin Lu
Publisher : Springer Nature
Release Date : 2020-05-22
Category : Medical
Total pages :403
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This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

The Autoimmune Diseases

The Autoimmune Diseases
Author : Noel R. Rose,Ian R. Mackay
Publisher : Academic Press
Release Date : 2019-10-15
Category : Medical
Total pages :1532
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The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment. Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy

Clinical Applications of Immunogenetics

Clinical Applications of Immunogenetics
Author : Muneeb U. Rehman,Shafat Ali
Publisher : Academic Press
Release Date : 2021-11-15
Category : Medical
Total pages :466
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Immunogenetic approaches to understand diseases provides the readers with an exclusive updated overview of scientific knowledge, achievements and findings in the field of immunogenetics. Immunogenetic approaches to understand diseases gives information from origin and development to immunogenetic approaches of several autoimmune and viral diseases. In thirteen chapters Immunogenetic approaches to understand diseases gives insight in advancements and approaches in the immunogenetics of viral and autoimmune diseases. Three chapters are dedicated to the immunogenetic mechanisms in the treatment of immune disorders, cancer, neurological and neurodegenerative disorders. Immunogenetic approaches to understand diseases also provides chapters on the immunogenomics of precision medicine, clinical medicine and transplantation. A special chapter is allocated to COVID 19: A novel challenge to human immune-genetic machinery. Immunogenetic approaches to understand diseases provides readily available updated information on the immunogenetic approaches of the most common viral and autoimmune diseases, that no doubt help the readers, researchers, scientists, teachers as well as clinicians in this field. Contains exclusive information about global research on immunogenetics Provides a solid foundation to researchers wanting to work on immunogenetics and their application to understand different autoimmune, virus and infectious diseases Delivers the information in a meticulous, attractive manner to make it more attractive to readers by being fully equipped with the pictures, illustrations and tables Gives insight to immunogenetics and its utility in therapeutics

Personalized Treatment Options in Dermatology

Personalized Treatment Options in Dermatology
Author : Thomas Bieber,Frank Nestle
Publisher : Springer
Release Date : 2015-02-23
Category : Medical
Total pages :146
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This book is a quick reference guide to the new, more personalized approaches to the management of skin disorders that have emerged as a result of progress in our understanding of the genetic background and pathophysiology of skin diseases and the diversity of mechanisms underlying their clinical heterogeneity. A wide range of personalized and targeted therapies are described, including those for different skin cancers, chronic inflammatory skin diseases, and autoimmune diseases. In addition, readers will find that the book documents how research results in personalized medicine can be effectively transferred to dermatological practice and looks forward to future treatments that might be developed on the basis of recent research findings. The authors are all recognized experts in the field, and the text is presented in a reader-friendly format and well illustrated.

Precision Medicine and the Reinvention of Human Disease

Precision Medicine and the Reinvention of Human Disease
Author : Jules J. Berman
Publisher : Academic Press
Release Date : 2018-01-26
Category : Business & Economics
Total pages :398
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Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine. Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine. Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter. Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way. Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field.

Handbook of Biomarkers and Precision Medicine

Handbook of Biomarkers and Precision Medicine
Author : Claudio Carini,Mark Fidock,Alain van Gool
Publisher : CRC Press
Release Date : 2019-04-16
Category : Mathematics
Total pages :631
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"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Towards Precision Medicine in Vasculitis

Towards Precision Medicine in Vasculitis
Author : Federico Alberici,Andreas Kronbichler,Giacomo Emmi
Publisher : Frontiers Media SA
Release Date : 2021-01-05
Category : Medical
Total pages :129
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Genome-Wide Association Studies

Genome-Wide Association Studies
Author : Tatsuhiko Tsunoda,Toshihiro Tanaka,Yusuke Nakamura
Publisher : Springer Nature
Release Date : 2019-10-31
Category : Medical
Total pages :209
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This book examines the utility of genome-wide association studies (GWAS) in the era of next-generation sequencing and big data, identifies limitations and potential means of overcoming them, and looks to the future of GWAS and what may lay beyond. GWAS are among the most powerful tools for elucidating the genetic aspects of human and disease diversity. In Genome-Wide Association Studies, experts in the field explore in depth the impacts of GWAS on genomic research into a variety of common diseases, including cardiovascular, autoimmune, diabetic, cancer, and infectious diseases. The book will equip readers with a sound understanding both of the types of disease and phenotypes that are suited for GWAS and of the ways in which a road map resulting from GWAS can lead to the realization of personalized/precision medicine: functional analysis, drug seeds, pathway analysis, disease mechanism, risk prediction, and diagnosis.

A Toolbox for Personalized Medicine of Methotrexate Therapy in Arthritis

A Toolbox for Personalized Medicine of Methotrexate Therapy in Arthritis
Author : Anonim
Publisher : Unknown
Release Date : 2014
Category :
Total pages :218
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Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases

Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases
Author : Azzam A. Maghazachi
Publisher : Frontiers Media SA
Release Date : 2017-09-18
Category :
Total pages :129
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More than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, among many others are manifestations of immune cells attacking normal tissues. On the other hand, damping the immune system leads to diseases such as cancer, AIDS, and severe combined immunodeficiency. The last ten years witnessed an explosion in developing drugs that target the immune system. Several novel monoclonal antibodies have been approved for treatment of various diseases confirming that personalized medicine approach is robust in combating diseases. Hence, the future holds great promise for using personalized and targeted medicine rather than generalized medications that, in most circumstances, proven to be ineffective and characteristically exert side effects. Approaches such as generating novel adjuvants that can stimulate the immune system without harmful side effects, targeting inflammatory cytokines and chemokines, harnessing and activating innate immune cells such as natural killer cells or dendritic cells, are examples of future approaches to treat autoimmune diseases, AIDS, and various forms of cancer resulting from chronic inflammation. More recently, targeting immune checkpoint molecules have shown therapeutic response against lung cancer and melanoma. Identifying molecules involved in autophagy is another example of how personalized medicine might help treat patients with refractory asthma and autoimmune diseases. This topic introduces the reader to these novel approaches of manipulating the immune system and developing targeted therapeutic strategies for treatment of various diseases.

Immunology and Allergy Clinics, An Issue of Immunology and Allergy Clinics of North America , E-Book

Immunology and Allergy Clinics, An Issue of Immunology and Allergy Clinics of North America , E-Book
Author : Mark Ballow,Elena Ronda Pérez
Publisher : Elsevier Health Sciences
Release Date : 2020-08-04
Category : Medical
Total pages :240
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This issue of Immunology and Allergy Clinics, guest edited by Dr. Mark Ballow and Dr. Elena Perez, will provide up-to-date clinical concepts regarding Immunodeficiencies. Articles in this outstanding issue include: Precision Medicine for Patients with Primary Immune Dysregulation, Immune Disorders Associated with Abnormalities in Treg Cells, Defining Common Variable Immunodeficiency, The Importance of Primary Immune Deficiency Registries, Chronic Lung Disease in Primary Antibody Deficiency: Diagnosis and Management, Immune Deficiencies Associated with Th17 Immunity, Truths and Myths of Vaccines in Patients with Primary Immune Deficiency, The Nuts and Bolts of Subcutaneous Immunoglobulin Replacement Therapy, Newly Discovered Primary Immune Deficiencies, and Specific Antibody Deficiency.

Textbook of Hyperbaric Medicine

Textbook of Hyperbaric Medicine
Author : Kewal K. Jain
Publisher : Hogrefe & Huber Pub
Release Date : 2004
Category : Medical
Total pages :536
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This textbook covers hyperbaric medicine and the applications of hyperbaric oxygen (HBO) techniques. It explains the basic principles of HBO therapy, and its application in carbon monoxide poisoning and decompression sickness, as well as its use in numerous other areas.