November 29, 2020

Download Ebook Free Precision Medicine For Autoimmune Diseases

Precision Medicine for Autoimmune Diseases

Precision Medicine for Autoimmune Diseases
Author : Georg Lautscham
Publisher : Academic Press
Release Date : 2020-09-01
Category : Medical
Total pages :366
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Autoimmune diseases have significant economic and social impacts and represent the second-most important market for pharmaceutical companies, which is unsurprising when you consider that, while 1 in 33 American will suffer from cancer, 1 in 22 Americans will suffer from an autoimmune disease, costing the US over $ 100 billion a year. However, the uptake of precision medicine in this area has been slow at best, even though it can be extremely difficult to accurately diagnose and treat patients effectively using the tools that are currently available. If the adoption of precision medicine is to truly gather pace among diseases outside of cancer, there are still several regulatory, technological, and funding-related hurdles to be overcome. Taking lessons learned from within the field of oncology and systematically applying them to areas such as autoimmune disease will enable the development of more effective drugs across a wider range of illnesses. Most importantly, this will lead to a better outcome for patients. Precision Medicine for Autoimmune Diseases summarizes the status, the ongoing activities and provides an outlook to the future. Addresses the fact that only one drug to treat autoimmune diseases was approved by FDA Shows the need to pick up and establish the need of personalized and precision medicine for autoimmune diseases Provides insight on how novel therapies, novel diagnostics and artificial intelligence work better together to advance the field of precision medicine in Autoimmune diseases Helps to establish a precision medicine approach for the benefit of patients, payers and industry

Precision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence
Author : Michael Mähler
Publisher : Academic Press
Release Date : 2021-04-01
Category : Science
Total pages :316
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Precision Medicine and Artificial Intelligence: The Perfect Fit covers background on AI, its link to PM, and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as artificial intelligence (AI) has gained significant attention in the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems has enabled the generation of large amounts of data, making autoimmunity an ideal target for AI in the field of Precision Medicine (PM). More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large data sets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to get a good overview of the field of Precision Medicine for autoimmune diseases and Artificial Intelligence Provides background, milestone and examples of precision medicine for autoimmune disease and artificial intelligence Proves the paradigm shift towards precision medicine driven by value based systems Discusses future applications of precision medicine research using artificial intelligence

Precision Medicine and the Reinvention of Human Disease

Precision Medicine and the Reinvention of Human Disease
Author : Jules J. Berman
Publisher : Academic Press
Release Date : 2018-01-26
Category : Business & Economics
Total pages :398
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Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine. Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine. Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter. Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way. Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field.

Handbook of Biomarkers and Precision Medicine

Handbook of Biomarkers and Precision Medicine
Author : Claudio Carini,Mark Fidock,Alain van Gool
Publisher : CRC Press
Release Date : 2019-04-16
Category : Mathematics
Total pages :631
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"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Omics for Personalized Medicine

Omics for Personalized Medicine
Author : Debmalya Barh,Dipali Dhawan,Nirmal Kumar Ganguly
Publisher : Springer Science & Business Media
Release Date : 2013-10-14
Category : Medical
Total pages :832
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“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

Clinical and Statistical Considerations in Personalized Medicine

Clinical and Statistical Considerations in Personalized Medicine
Author : Claudio Carini,Sandeep M Menon,Mark Chang
Publisher : CRC Press
Release Date : 2014-03-27
Category : Mathematics
Total pages :376
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The Future of Clinical Research and Health Care: From Empirical to Precision Medicine Clinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease Treatment The first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers. Improve Patient Care and Reduce Costs and Side Effects Despite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.

Genomic and Personalized Medicine

Genomic and Personalized Medicine
Author : Anonim
Publisher : Academic Press
Release Date : 2012-10-30
Category : Science
Total pages :1350
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Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Genomics, Personalized Medicine and Oral Disease

Genomics, Personalized Medicine and Oral Disease
Author : Stephen T. Sonis, DMD, DMSc
Publisher : Springer
Release Date : 2015-09-17
Category : Medical
Total pages :408
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The objective of this book is to catalyze the application of genomics to the diagnosis and treatment of oral diseases by comprehensively presenting focused discussions on the current state of knowledge. The first section book provides basic information about genetics, genomics and personalized medicine and the informatical methods available to apply and organize genetic data so that it has clinical relevance. Recognizing the genetic robustness of the oral cavity, the introductory section includes chapters on the oral micro biome and host genomics and response to infectious agents. The next two sections contain chapters which describe the genomics of specific oral diseases and conditions, including the genetic basis for mechanism and risk of treatment toxicities associated with cancer therapy and bisphosphonates. Four chapters focus on gene-based therapies and the pharmacogenomics applied to oral disease. The final chapter presents a provocative summary which describes a comprehensive vision of the melding of genomics to personalized medicine and the potential actionable outcomes that will likely affect clinical practice in the upcoming years.

The Autoimmune Diseases

The Autoimmune Diseases
Author : Noel R. Rose,Ian R. Mackay
Publisher : Unknown
Release Date : 1985
Category : Medical
Total pages :727
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The Autoimmune Diseases is composed of 25 chapters dealing with different aspects of some specific autoimmune diseases. The book begins with the elucidation of the genetic predisposition to autoimmune diseases. Subsequent chapters explore numerous kinds of autoimmune diseases. Other chapters describe the antireceptor antibodies and the sensitivity and specificity of autoantibody testing. This book is designed to provide a deeper understanding of this increasingly important field of medical science for physicians and investigators involved in the diagnosis, treatment, or research of autoimmune ...

Epigenetics in Allergy and Autoimmunity

Epigenetics in Allergy and Autoimmunity
Author : Christopher Chang,Qianjin Lu
Publisher : Springer Nature
Release Date : 2020-05-22
Category : Medical
Total pages :403
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This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

Immune Rebalancing

Immune Rebalancing
Author : Diana Boraschi,Giselle Penton-Rol
Publisher : Academic Press
Release Date : 2016-01-25
Category : Medical
Total pages :298
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Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposes Encourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infections Examines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approaches Provides information on the new strategies for drug development in this field Considers the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader’s strategy for addressing therapeutic immune modulations

The Personalized Medicine Revolution

The Personalized Medicine Revolution
Author : Pieter Cullis
Publisher : Greystone Books
Release Date : 2015-02-10
Category : Health & Fitness
Total pages :176
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Every one of us is unique. With recent advances in technology, we now know that that statement is more true that ever: we are each individuals, right down to a molecular level — a one-of-a-kind combination of genes, proteins, and metabolism. So why does healthcare still take a one-size-fits-all approach? The same methods are used on everyone to diagnose illness, and the same drugs are used to treat it — despite the fact that those methods and treatments are not effective for everyone and are even harmful for some. Shouldn’t our medicine be tailored to our differences? The Personalized Medicine Revolution explores recent advances in genomics, the study of the human genome — as well as its cousins proteomics, metabolomics, microbiomics, and the like — and explains how technology is even now changing the way medicine is delivered. Along the way, it takes the reader through the five critical healthcare areas that will be transformed most radically by personalized medicine — prediction, prevention, diagnosis, treatment, and monitoring — and examines the practical and ethical issues involved. Finally, it details how readers can use personalized medicine to take charge of their own health and build a stronger and safer medical system.

Personalized Treatment Options in Dermatology

Personalized Treatment Options in Dermatology
Author : Thomas Bieber,Frank Nestle
Publisher : Springer
Release Date : 2015-02-23
Category : Medical
Total pages :146
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This book is a quick reference guide to the new, more personalized approaches to the management of skin disorders that have emerged as a result of progress in our understanding of the genetic background and pathophysiology of skin diseases and the diversity of mechanisms underlying their clinical heterogeneity. A wide range of personalized and targeted therapies are described, including those for different skin cancers, chronic inflammatory skin diseases, and autoimmune diseases. In addition, readers will find that the book documents how research results in personalized medicine can be effectively transferred to dermatological practice and looks forward to future treatments that might be developed on the basis of recent research findings. The authors are all recognized experts in the field, and the text is presented in a reader-friendly format and well illustrated.

Systems Medicine Modeling for Multiple Sclerosis

Systems Medicine Modeling for Multiple Sclerosis
Author : Anonim
Publisher : Unknown
Release Date : 2017
Category :
Total pages :129
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Abstract: Multiple Sclerosis (MS) is an autoimmune disease in which axons and myelin of the central nervous system (CNS) are damaged by inflammation and degenerative processes leading to significant disability. The course of the MS is hard to predict, limiting the decision making process for patient management and therapeutic options. Many genetic, lifestyle and environmental factors could influence the risks of MS development. Subtle abnormalities in the control of the immune response can be amplified and deregulated decades later suggesting that MS and other autoimmune diseases can be envisioned as dynamic diseases. Based on this premise, mathematical modeling of MS pathogenesis is an approach that would bring this dynamic concept to the understanding of the disease and therefore be useful for improving our understanding for the application of precision medicine. Modeling can be focused on different biological scales from genes and signaling pathways to cell–cell interactions, interplay between inflammatory and degenerative processes at tissue level, and predictions of clinical outcomes. Models of the autoimmune process as well as the damage of the CNS has been developed using ordinary differential equations and fitted parameters with experimental datasets. Simulations support the concept of MS as a dynamic disease that is being produced by subtle differences in the molecular and cellular control of the immune-nervous interplay amplified along time. These new systems medicine tools can now be applied for patient stratification and personalized medicine. Highlights: Predicting disease course and response to therapy is difficult in MS. Systems medicine models of MS focused in network and mathematical models. Computational models of MS will allow systems medicine applications.

Personalized Epigenetics

Personalized Epigenetics
Author : Trygve Tollefsbol
Publisher : Academic Press
Release Date : 2015-04-28
Category : Science
Total pages :610
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Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management