November 30, 2020

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Principles of Bone Biology

Principles of Bone Biology
Author : John P. Bilezikian,Lawrence G. Raisz,T. John Martin
Publisher : Academic Press
Release Date : 2008-09-29
Category : Medical
Total pages :1900
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Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition

Principles of Bone Biology

Principles of Bone Biology
Author : John P. Bilezikian,T. John Martin,Thomas L. Clemens,Clifford Rosen
Publisher : Academic Press
Release Date : 2019-08-22
Category : Science
Total pages :2024
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Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science... we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end, Principles of Bone Biology was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan Praise for the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine For over two decades, "Big Gray" has been the go-to repository of knowledge in the disciplines related to bone and mineral metabolism. The fourth edition is a must-have for students new to the field; young investigators at the graduate or postgraduate level beginning their research careers; established scientists who need to keep up with the changing nature of the field, looking to enrich their own research programs, or who are changing their career direction; clinicians who want ready access to up-to-date relevant basic science. This new edition builds on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. Principles of Bone Biology, Fourth Edition provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. Bone research continues to generate enormous attention, due to the broad public health implications of osteoporosis and related bone disorders. This classic, fully updated, two volume reference is designed for anyone involved in the study of bone biology. Provides a "one-stop" shopping paradise. Anything you want to find about bone biology is here and written by the world’s experts THE essential resource for anyone involved in the study of the skeleton and metabolic bone diseases Covers everything from the basic scientific concepts to the underlying principles of therapeutics and management Allows readers to easily search and locate information quickly in the online format Volumes include: Basic Principles; Molecular Mechanisms of Metabolic Bone Disease; Pharmacological Mechanisms of Therapeutics; Methods in Bone Research

Principles of Bone Biology

Principles of Bone Biology
Author : John P. Bilezikian,Lawrence G. Raisz,Gideon A. Rodan
Publisher : Academic Press
Release Date : 2002-01-19
Category : Medical
Total pages :1696
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Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. The most current and timely source of information about the biology and pathology of bone Provides succinct coverage of the subject Contributors include over 200 of the most respected researchers in the field Extensive table of contents and index for easy reference Easy-to-read and highly informative to both the newcomer and the initiated to the field Spans the spectrum from molecular biology to in vivo pharmacology Complete bibliography with each entry fully referenced for additional background reading First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996

Principles of Bone Biology: Molecular mechanisims of metabolic bone diseases

Principles of Bone Biology: Molecular mechanisims of metabolic bone diseases
Author : John P. Bilezikian,Lawrence Gideon Raisz,Gideon A. Rodan
Publisher : Unknown
Release Date : 2002
Category : Bones
Total pages :1696
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Basic and Applied Bone Biology

Basic and Applied Bone Biology
Author : David B. Burr,Matthew R. Allen
Publisher : Academic Press
Release Date : 2013-06-11
Category : Medical
Total pages :390
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This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models. Presents an in-depth overview of skeletal biology from the molecular to the organ level Offers "refresher" level content for clinicians or researchers outside their areas of expertise Boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology

Translational Endocrinology of Bone

Translational Endocrinology of Bone
Author : Gerard Karsenty
Publisher : Academic Press
Release Date : 2012-12-31
Category : Medical
Total pages :236
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The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. This book is a timely reference for both basic and clinical researchers in bone biology and endocrinology. Summarizes the latest research and translational applications of how the varied growth and development of bone affects appetite, metabolism, reproduction, and a wide range of endocrine functions Provides a common language for bone biologists, endocrinologists, osteologists, and other researchers, such as neuroscientists, who study appetite, fuel metabolism and diabetes, to discuss the development of translational research and new therapeutic strategies for bone, metabolic, and neuro-endocrine diseases. Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone research and therapeutics, as opposed to searching through thousands of journal articles

Current Topics in Bone Biology

Current Topics in Bone Biology
Author : Hong-wen Deng,Yao-zhong Liu,Chun-yuan Guo,Di Chen
Publisher : World Scientific
Release Date : 2005-05-09
Category : Medical
Total pages :540
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This book covers a wide spectrum of areas related to basic bone research. While bone remodeling, bone development, and osteoclast biology constitute the main contents, topics important to the understanding of bone metabolism and treatment of bone-related diseases are also intensively reviewed. Three chapters are dedicated to the classic topic of bone mechanics, which include a brief overview of the mechanostat hypothesis, a more detailed review on mechanotransduction and bone adaptation, and a chapter illustrating the basic principles of bone mechanical testing. New emerging fields such as skeletal stem cells, bone tissue engineering, phytoestrogens applications, and bone genetics study using mouse models, are also covered in detail. The book closes with a special chapter dedicated to state-of-the-art advances in bone biology research. Contents:International Chinese Hard Tissue Society — The Power that Connects the World of Science and Culture (D X Ji & W S S Jee)Integrated Bone Tissue Anatomy and Physiology (X-J Li & W S S Jee)Skeletal Stem Cells (M Connolly & G Li)Osteoclast Biology (X Feng & H Zhou)Intercellular Communication of Osteoblast and Osteoclast in Bone Diseases (J Xu et al.)Osteoclasts and Inflammatory Osteolysis (L Xing et al.)Endochrondral Bone Formation and Extracellular Matrix (Q Chen et al.)Bone Morphogenetic Proteins in Bone Formation and Development (X-J Qi et al.)Mechanical Testing for Bone Specimens (L Qin & M Zhang)Estrogens and Androgens on Bone Metabolism (A Kung & J Gu)Phytoestrogens and Bone Health: Mechanisms of Action (Z C Dang)Regulation of Bone Remodeling (D Chen et al.)TGFB in Chondrocyte Biology and Cartilage Pathology (T F Li et al.)Bone Health in Children and Adolescents (J M Lappe)The Mechanostat Hypothesis for Bones and Other Skeletal Organs (H M Frost)Mechanotransduction and Its Role in Bone Adaptation (Y Qin & C Rubin)Bio-Pathology of Bone Tumors (L Huang et al.)Bone Tissue Engineering (X Yang & R O C Oreffo)Bone Genetic Factors Determined Using Mouse Models (W Gu & Y Jiao)Recent Advances in Bone Biology Research (D Chen et al.) Readership: Scientists and researchers in the bone field; clinicians, especially endocrinologists, orthopedists, gynecologists and pediatricians; medical students; and students majoring in biomedical sciences (undergraduate and graduate). Keywords:Bone;Skleton;Osteoclast;Osteoblast;Osteoporosis;RemodelingKey Features:Book covers both classic topics in bone research and new advancesTopics covered represent the most active areas of bone researchContributions from leading experts such as Dr Harold M Frost, regarded by most as the most influential theoretician in skeletal biology in the last fifty years, and Dr Webster S S Jee

Principles of Osteoimmunology

Principles of Osteoimmunology
Author : Peter Pietschmann
Publisher : Springer
Release Date : 2016-08-18
Category : Medical
Total pages :328
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This fully updated and extended second edition provides a comprehensive overview on the basic concepts of the rapidly developing field of osteoimmunology and also offers in-depth insights into the molecular mechanisms of bone diseases. Clinical data is presented and put into context with the latest research findings. This second edition in addition discusses the latest topics in transplantation immunology. The book addresses scientists and physicians working in immunology, pathophysiology and osteology.

Genetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease
Author : Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
Publisher : Academic Press
Release Date : 2017-10-31
Category : Medical
Total pages :878
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Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

Bone Tissue Engineering

Bone Tissue Engineering
Author : Jeffrey O. Hollinger,Thomas A. Einhorn,Bruce Doll,Charles Sfeir
Publisher : CRC Press
Release Date : 2004-10-14
Category : Medical
Total pages :352
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Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, the book covers basic bone biology and tissue engineering, scaffold designs for tissue engineering, applied principles of bone tissue engineering, and clinical opportunities. The comprehensive nature of this book, including extensive bibliographies, will make it an invaluable resource for biomedical engineers, tissue engineers, dental and bone-related medical researchers, and craniofacial biologists.

Bone Histomorphometry

Bone Histomorphometry
Author : Erik Fink Eriksen,Douglas W. Axelrod,Flemming Melsen
Publisher : Lippincott Williams & Wilkins
Release Date : 1994
Category : Medical
Total pages :74
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Addresses skeletal growth modeling & remodeling/bone macroanatomy & microanatomy/bone mass measurements/etc.

Principles of Bone Regeneration

Principles of Bone Regeneration
Author : Jona J. Sela,Itai A. Bab
Publisher : Springer Science & Business Media
Release Date : 2012-03-10
Category : Technology & Engineering
Total pages :156
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Principles of Bone Regeneration is a timely publication that addresses the modern aspects of bone healing and repair. This exciting new volume details the convergence of the different experimental and clinical approaches designed for the study and treatment of bone healing in its diverse forms and under varying conditions. Bone healing is affected by a multitude of genetic, environmental, mechanical, cellular and endocrine variables which eventually lead to changes in gene expression that enhance the guided action of osteoblasts (and chondroblasts) to lay down bone that restores, or even improves, the skeletal load bearing capacity. Recent breakthroughs in understanding the regulatory aspects of bone formation and resorption, in both research and clinical arenas offer new modalities to induce, enhances and guide repair processes in bone for the benefit of millions of patients with conditions such as nonunion fractures, critical size defects, orthodontic tooth movement, periodontal bone loss, intraosseous implants and deformed bones.

The Aging Skeleton

The Aging Skeleton
Author : Clifford J. Rosen,Julie Glowacki,John P. Bilezikian
Publisher : Elsevier
Release Date : 1999-08-19
Category : Medical
Total pages :642
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The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics. Covers all aspects of the aging skeleton in one comprehensive volume Looks at the influence of genetics, nutrition, environment, hormones, and other factors on bone mass Provides a thorough discussion of fractures, one of the major consequences of the aging skeleton Reviews current therapeutic approaches and methods Written by internationally renowned authors and edited by leaders in the field Is the only book available on this subject

Dynamics of Bone and Cartilage Metabolism

Dynamics of Bone and Cartilage Metabolism
Author : Markus J. Seibel,Simon P. Robins,John P. Bilezikian
Publisher : Elsevier
Release Date : 2006-07-24
Category : Medical
Total pages :920
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This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components Part II covers the organizational structure and cellular metabolism of bone and cartilage Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

Principles of Tissue Engineering

Principles of Tissue Engineering
Author : Robert Lanza,Robert Langer,Joseph P. Vacanti
Publisher : Elsevier
Release Date : 2000-05-16
Category : Science
Total pages :995
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The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field. Key Features * Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves * Essential to anyone working in the field * Educates and directs both the novice and advanced researcher * Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves * Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell * Considered the definitive reference in the field * List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others