June 17, 2021

Download Ebook Free Process Systems Engineering For Pharmaceutical Manufacturing

Process Systems Engineering for Pharmaceutical Manufacturing

Process Systems Engineering for Pharmaceutical Manufacturing
Author : Ravendra Singh,Zhihong Yuan
Publisher : Unknown
Release Date : 2018-03
Category :
Total pages :612
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Process Systems Engineering for Pharmaceutical Manufacturing: From Product Design to Enterprise-Wide Decisions, Volume 41 covers the following process systems engineering methods and tools for the modernization of the pharmaceutical industry: computer-aided pharmaceutical product design and pharmaceutical production processes design/synthesis; modeling and simulation of the pharmaceutical processing unit operation, integrated flowsheets and applications for design, analysis, risk assessment, sensitivity analysis, optimization, design space identification and control system design; optimal operation, control and monitoring of pharmaceutical production processes; enterprise-wide optimization and supply chain management for pharmaceutical manufacturing processes. Currently, pharmaceutical companies are going through a paradigm shift, from traditional manufacturing mode to modernized mode, built on cutting edge technology and computer-aided methods and tools. Such shifts can benefit tremendously from the application of methods and tools of process systems engineering. Introduces Process System Engineering (PSE) methods and tools for discovering, developing and deploying greener, safer, cost-effective and efficient pharmaceutical production processes Includes a wide spectrum of case studies where different PSE tools and methods are used to improve various pharmaceutical production processes with distinct final products Examines the future benefits and challenges for applying PSE methods and tools to pharmaceutical manufacturing

Process Systems Engineering for Pharmaceutical Manufacturing

Process Systems Engineering for Pharmaceutical Manufacturing
Author : Ravendra Singh,Zhihong Yuan
Publisher : Elsevier
Release Date : 2018-03-16
Category : Technology & Engineering
Total pages :698
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Process Systems Engineering for Pharmaceutical Manufacturing: From Product Design to Enterprise-Wide Decisions, Volume 41, covers the following process systems engineering methods and tools for the modernization of the pharmaceutical industry: computer-aided pharmaceutical product design and pharmaceutical production processes design/synthesis; modeling and simulation of the pharmaceutical processing unit operation, integrated flowsheets and applications for design, analysis, risk assessment, sensitivity analysis, optimization, design space identification and control system design; optimal operation, control and monitoring of pharmaceutical production processes; enterprise-wide optimization and supply chain management for pharmaceutical manufacturing processes. Currently, pharmaceutical companies are going through a paradigm shift, from traditional manufacturing mode to modernized mode, built on cutting edge technology and computer-aided methods and tools. Such shifts can benefit tremendously from the application of methods and tools of process systems engineering. Introduces Process System Engineering (PSE) methods and tools for discovering, developing and deploying greener, safer, cost-effective and efficient pharmaceutical production processes Includes a wide spectrum of case studies where different PSE tools and methods are used to improve various pharmaceutical production processes with distinct final products Examines the future benefits and challenges for applying PSE methods and tools to pharmaceutical manufacturing

Process Systems Engineering Methods for the Development of Continuous Pharmaceutical Manufacturing Processes

Process Systems Engineering Methods for the Development of Continuous Pharmaceutical Manufacturing Processes
Author : Amanda Rogers
Publisher : Unknown
Release Date : 2015
Category : Manufacturing processes
Total pages :170
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The objective of this dissertation is to develop mathematical methods to assist in the development of continuous processes for the manufacture of pharmaceutical drug products. Specifically, modeling, analysis and optimization techniques will be developed in order to apply concepts from the field of process systems engineering to pharmaceutical development. These concepts, including sensitivity analysis, feasibility and flexibility analysis and optimal design under uncertainty, can contribute to the development of robust and well-understood manufacturing processes. This is consistent with the aim Quality-by-Design in the pharmaceutical process development. Throughout this dissertation, case studies related to continuous solids-based manufacturing will be used to demonstrate the role that process systems engineering can play in process development. The mathematical methods introduced in this dissertation will emphasize the use of reduced-order and surrogate models to address the unique challenges associated with modeling, analysis and optimization of solids-based processes.

Process Systems Engineering of Continuous Pharmaceutical Manufacturing

Process Systems Engineering of Continuous Pharmaceutical Manufacturing
Author : Matthew J. Abel
Publisher : Unknown
Release Date : 2009
Category :
Total pages :299
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(Cont.) This reduction in equipment size translates to capital cost (CAPEX) savings for both the continuous process equipment and manufacturing facilities. The steady state operation of continuous processing also reduces the labor requirements and gives the continuous processes an operating cost (OPEX) advantage over batch processes. This research has contributed to the understanding of continuous pharmaceutical powder blending and quantified some of the benefits of continuous downstream pharmaceutical manufacturing. This work is being continued by the Novartis-MIT Center for Continuous Manufacturing whose work is providing the foundation for future industrial scale pharmaceutical continuous manufacturing systems.

10th International Symposium on Process Systems Engineering

10th International Symposium on Process Systems Engineering
Author : Rita Maria de Brito Alves,Cláudio Augusto Oller do Nascimento,Evaristo Chalbaud Biscaia (Jr)
Publisher : Elsevier
Release Date : 2009
Category : Technology & Engineering
Total pages :1224
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The 10th International Symposium on Process Systems Engineering, PSE'09, will be held in Salvador-Bahia, Brazil on August 16-20, 2009. The special focus of PSE 2009 is Sustainability, Energy and Engineering. PSE 2009 is the tenth in the triennial series of international symposia on process systems engineering initiated in 1982. The meeting is brings together the worldwide PSE community of researchers and practitioners who are involved in the creation and application of computing-based methodologies for planning, design, operation, control and maintenance of chemical and petrochemical process industries. PSE'09 will look at how the PSE methods and tools can support sustainable resource systems and emerging technologies in the areas of green engineering: environmentally conscious design of industrial processes. PSE methods and tools support: - sustainable resource systems - emerging technologies in the areas of green engineering - environmentally conscious design of industrial processes

Continuous Manufacturing of Pharmaceuticals

Continuous Manufacturing of Pharmaceuticals
Author : Peter Kleinebudde,Johannes Khinast,Jukka Rantanen
Publisher : John Wiley & Sons
Release Date : 2017-07-14
Category : Science
Total pages :632
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A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process manufacturing provides a proven solution. Among its many benefits are: minimized waste, energy consumption, and raw material use; the accelerated introduction of new drugs; the use of smaller production facilities with lower building and capital costs; the ability to monitor drug quality on a continuous basis; and enhanced process reliability and flexibility. Continuous Manufacturing of Pharmaceuticals prepares professionals to take advantage of that exciting new approach to improving drug manufacturing efficiency. This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and protein/peptide products. The following section is devoted to process analytical tools for continuously operating manufacturing environments. The final two sections treat the integration of several individual parts of processing into fully operating continuous process systems and summarize state-of-art approaches for innovative new manufacturing principles. Brings together the essential know-how for anyone working in drug manufacturing, as well as chemical, food, and pharmaceutical scientists working on continuous processing Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design Contains contributions from researchers in leading pharmaceutical companies, the FDA, and academic institutions Offers an extremely well-informed look at the most promising future approaches to continuous manufacturing of innovative pharmaceutical products Timely, comprehensive, and authoritative, Continuous Manufacturing of Pharmaceuticals is an important professional resource for researchers in industry and academe working in the fields of pharmaceuticals development and manufacturing.

Sterile Pharmaceutical Products

Sterile Pharmaceutical Products
Author : KennethE. Avis
Publisher : Routledge
Release Date : 2018-03-29
Category : Medical
Total pages :428
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Sterile Pharmaceutical Products: Process Engineering Applications addresses the key concepts and applications of the sterile pharmaceutical manufacturing industry. It covers elements of the design, installation, validation, and usage of critical processes associated with sterile product manufacture. From water systems to clean-in-place systems, to sterile powder handling and robotic applications in sterile production environments, this book addresses the issues of system implementation, integration, and operations. Written by recognized experts and peer reviewed for accuracy, all chapters include references to supplemental resources and numerous illustrations.

The Chemical Engineer

The Chemical Engineer
Author : Anonim
Publisher : Unknown
Release Date : 2007
Category : Chemical engineering
Total pages :129
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23 European Symposium on Computer Aided Process Engineering

23 European Symposium on Computer Aided Process Engineering
Author : Anshu Gupta,Aran Giridhar,Ginataras V. Reklaitis,Venkat Venkatasubramanian
Publisher : Elsevier Inc. Chapters
Release Date : 2013-06-10
Category : Science
Total pages :1088
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One of the important challenges in effective real time process management is the implementation of intelligent systems that can assist human operators in making supervisory control decisions, instead of simply sounding an alarm when process variables go out of range. Operator failures to exercise the appropriate mitigation actions often have an adverse effect on product quality, process safety, occupational health and environment. The challenges and opportunities for improvements are even greater in the pharmaceutical manufacturing domain because of the characteristic features of solid processing. An Intelligent Alarm System (IAS) is developed for monitoring of a continuous dry granulation line. The application of the framework is demonstrated through a case study on a roller compactor. The framework provides information to the operator regarding the detection and diagnosis of exceptional events along with relevant mitigation strategies, with the goal of avoiding the progression of the process to emergency shutdown.

Who's who in Technology Today

Who's who in Technology Today
Author : Anonim
Publisher : Unknown
Release Date : 1980
Category : Engineers
Total pages :129
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Food Processing Industry

Food Processing Industry
Author : Anonim
Publisher : Unknown
Release Date : 1974
Category : Food industry and trade
Total pages :129
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Chemical and Engineering News

Chemical and Engineering News
Author : Anonim
Publisher : Unknown
Release Date : 1995
Category : Chemical engineering
Total pages :129
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Model-based design of optimal reactors for (bio)pharmaceutical manufacturing

Model-based design of optimal reactors for (bio)pharmaceutical manufacturing
Author : Victor N. Emenike
Publisher : Cuvillier Verlag
Release Date : 2019-11-22
Category : Medical
Total pages :194
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Die Pharmaindustrie durchläuft einen tiefgreifenden Wandel, der durch eine technologische Revolution der Herstellungsverfahren getrieben wird. Im Mittelpunkt des Umbruches steht das Quality by-Design, das von der amerikanischen Food and Drug Administration initiiert wurde, um die Entwicklung zukünftiger Fertigungsprozesse für nieder- und hochmolekulare Medikamente zu steuern. Basierend auf den Anforderungen der Industrie und unter Berücksichtigung der aktuellen Fachliteratur spielen systemverfahrenstechnische Konzepte (engl. Process Systems Engineering) bei der Implementierung von Qualityby- Design-Methoden eine entscheidende Rolle.

Thomas Register of American Manufacturers and Thomas Register Catalog File

Thomas Register of American Manufacturers and Thomas Register Catalog File
Author : Anonim
Publisher : Unknown
Release Date : 2003
Category : Industrialists
Total pages :129
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Vols. for 1970-71 includes manufacturers' catalogs.

Proceedings of the National Science Council, Republic of China

Proceedings of the National Science Council, Republic of China
Author : Anonim
Publisher : Unknown
Release Date : 2001
Category : Engineering
Total pages :129
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