June 18, 2021

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Psychiatric Genetics

Psychiatric Genetics
Author : Thomas Schulze,Francis McMahon
Publisher : Oxford University Press
Release Date : 2018
Category : Medical
Total pages :240
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Psychiatrists and other mental health professionals are increasingly confronted with questions about the genetics of psychiatric illness, and the clinical applications of new genetic findings. Psychiatric Genetics: A Primer for Clinical and Basic Scientists addresses these questions through a straightforward introduction to the essentials of psychiatric genetics, complementing more comprehensive textbooks that may seem overwhelming for those new to the field. Written and edited by leaders in the field and the International Society of Psychiatric Genetics (ISPG), the book covers basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of "take home" points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading. This Primer is ideal for medical students, psychiatric residents, psychiatrists, and basic neuroscience researchers who are interested in learning about the key concepts and recent advances in the exciting field of psychiatric genetics.

Psychiatric Genomics

Psychiatric Genomics
Author : Evangelia Eirini Tsermpini,Martin Alda,George P. Patrinos
Publisher : Academic Press
Release Date : 2020-12-15
Category : Medical
Total pages :424
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Psychiatric Genomics presents and synthesizes available knowledge in the field of psychiatric genomics, offering methodologies to advance new research and aid clinical translation. After providing an introduction to genomics and psychiatry, international experts discuss the genomic basis of schizophrenia, bipolar disorder, depression, personality disorders, anxiety disorders, addictions, eating disorders, and sleep disorders, among other disorders. In addition, recommendations for next steps in clinical implementation and drug discovery are discussed in-depth, with chapters dedicated to pharmacogenomics and antipsychotics, antidepressants and mood stabilizers, adverse drug reactions, implementation of pharmacogenomics in psychiatric clinics, and ethical issues. Finally, methods sections provide a solid grounding in research approaches and computational analytics, from using animal models in psychiatric genomics and accessing biobanks, to employing computational analysis, genome-wide association studies (GWAS), brain pathophysiology, and endophenotypes in psychiatric research. Thoroughly examines the genetic mechanisms underlying a broad range of psychiatric disorders Offers genomic methodologies and analytical approaches supporting new research and clinical translation, including personalized diagnosis and treatment models Features chapter contributions from international leaders in the field

Psychiatric Genetics and Genomics

Psychiatric Genetics and Genomics
Author : Peter McGuffin,Michael J Owen,Irving I Gottesman
Publisher : Oxford University Press
Release Date : 2004-09-23
Category : Medical
Total pages :492
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Genetics promises to provide one of the most powerful approaches to understanding the functional pathology of the human brain. This book starts with a brief introduction to the relevant molecular and cellular biology and then moves on to cover the evidence for a genetic contribution to normal and abnormal development and to abnormal behaviour in adult life. The final section covers counselling, ethics and takes a look to the future.

Advances in Psychiatric Genomics

Advances in Psychiatric Genomics
Author : Anonim
Publisher : Unknown
Release Date : 2012
Category :
Total pages :98
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Research Advances in Genetics and Genomics

Research Advances in Genetics and Genomics
Author : Nancy C. Andreasen
Publisher : American Psychiatric Pub
Release Date : 2007-05-03
Category : Medical
Total pages :160
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Research Advances in Genetics and Genomics: Implications for Psychiatry introduces mental health professionals to exciting breakthroughs in endophenotypes, animal models, microarrays, and genetic mapping, as well as general strategies for identifying the genetic mechanisms of mental illnesses. Uniquely valuable both as summary and signpost, this concise volume provides a fascinating overview of recent cutting-edge developments in the application of molecular genetics, genomics, and proteomics to the study of psychiatric populations. By reading Research Advances in Genetics and Genomics, you will gain a better understanding of Psychiatric Genetics -- Reviews and assesses the major research paradigms that have emerged in the field of psychiatric genetics over the several past decades, exploring the major conceptual and philosophical issues they pose and the value of their integration. Molecular Structure of Nucleic Acids -- An overview of the double-helix discovery and provides a context for current endeavors, the original one-page April 1953 Nature paper by Watson and Crick, which sparked a revolution in the life sciences. Psychiatry in the Genomics Era -- Posits that one of the most important consequences of genomics will be the development of individualized treatments that allow a clinician to tailor therapy on the basis of the unique genotype of each patient rather than on the mean responses of groups of unrelated patients. The Genomics Revolution -- Details the implications of the genome for future medical practice, including the potential for developing methods and tools to better understand, treat, and prevent major mental disorders. The Endophenotype Concept in Psychiatry -- Explains the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics, such as schizophrenia. The Genes and Brains of Mice and Men -- Shows why a detailed assessment of brain function in mice is so important for advancing psychiatric research in humans. Humans and mice share numerous features-in fact, for an estimated 99% of human genes a mouse version may be identified-of brain organization and behavioral responses to many pharmacological agents. Microarray Technology -- Asserts that microarrays present a methodology for identifying genes or pathways for new and unique potential drug targets, determining premorbid diagnosis, predicting drug responsiveness for individual patients, and, eventually, initiating gene therapy and prevention strategies. Meticulously referenced, this volume is exceptionally useful as a starting point for understanding the impact of genetics and genomics on psychiatry, serving to introduce psychiatrists, psychologists, neurologists, and geneticists to this exciting field.

Psychiatric Genetics

Psychiatric Genetics
Author : Thomas Schulze,Francis McMahon
Publisher : Oxford University Press
Release Date : 2018-04-06
Category : Medical
Total pages :129
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Psychiatrists and other mental health professionals are increasingly confronted with questions about the genetics of psychiatric illness, and the clinical applications of new genetic findings. Psychiatric Genetics: A Primer for Clinical and Basic Scientists addresses these questions through a straightforward introduction to the essentials of psychiatric genetics, complementing more comprehensive textbooks that may seem overwhelming for those new to the field. Written and edited by leaders in the field and the International Society of Psychiatric Genetics (ISPG), the book covers basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of "take home" points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading. This Primer is ideal for medical students, psychiatric residents, psychiatrists, and basic neuroscience researchers who are interested in learning about the key concepts and recent advances in the exciting field of psychiatric genetics.

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry

Genomics, Circuits, and Pathways in Clinical Neuropsychiatry
Author : Thomas Lehner,Bruce L. Miller,Matthew W. State
Publisher : Academic Press
Release Date : 2016-06-07
Category : Science
Total pages :796
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This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Textbook of Psychiatric Epidemiology

Textbook of Psychiatric Epidemiology
Author : Ming T. Tsuang,Mauricio Tohen,Peter Jones
Publisher : John Wiley & Sons
Release Date : 2011-04-25
Category : Medical
Total pages :646
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Rev. ed. of: Textbook in psychiatric epidemiology / edited by Ming T. Tsuang, Mauricio Tohen. 2nd ed. c2002.

Lasso Meta-regression and Its Application to Psychiatric Genomics

Lasso Meta-regression and Its Application to Psychiatric Genomics
Author : Charles A. Laurin
Publisher : Unknown
Release Date : 2014
Category : Behavior genetics
Total pages :85
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Psychiatric Epidemiology

Psychiatric Epidemiology
Author : Ezra S. Susser,Evelyn J. Bromet,Alfredo Morabia,Sharon Schwartz
Publisher : Oxford Psychiatry
Release Date : 2006
Category : Medical
Total pages :516
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Starting out by tracing the brief history of psychiatric epidemiology, this text describes the study of risk factors as causes of mental disorders. Subsequent sections discuss approaches to investigation of biologic, genetic or social causes and the statistical analysis of study results.

Genomics, Proteomics, and the Nervous System

Genomics, Proteomics, and the Nervous System
Author : James D Clelland
Publisher : Springer Science & Business Media
Release Date : 2010-12-03
Category : Medical
Total pages :592
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This newest volume of Advances in Neurobiology discusses the utilization of genomic and proteomic technologies, to address facets of neurobiology including development and epigenetic regulation, functions in learning and memory, and changes associated with neurological and psychiatric disorders.

Genetics and Psychiatric Disorders

Genetics and Psychiatric Disorders
Author : Jan Wahlstrom,Jan Wahlström
Publisher : Elsevier Science Limited
Release Date : 1998
Category : Psychology
Total pages :326
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Hardbound. Over the past few years, there has been much research into, and subsequent advances in our understanding of, the genetic causes of psychiatric illness. Most neuropsychiatric diseases have a multifactorial background - both genetic and environmental factors are important for the development of the disease. The advantages of understanding the inherited component of a psychiatric disease are obviously great, and will eventually lead to more effective treatments.The chapters in this volume are specifically concerned with the latest advances in finding biological and genetic markers for psychiatric disorders. An emphasis is placed on common diseases such as schizophrenia and bipolar disorders. However, for instance, monogenetic inherited diseases with psychiatric symptoms which can serve as models for the inheritance of psychiatric disorders are also discussed.For neuroscientists, geneticists, biological psychiatrists and all those with

Statistics in Human Genetics

Statistics in Human Genetics
Author : Pak Sham
Publisher : Wiley
Release Date : 1997-12-08
Category : Science
Total pages :300
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This is one of the first introductions to the sophisticated statistical methods that play a key role in research on human genetics. Topics include the estimation of allele frequencies, the testing for Hardy-Weinberg equilibrium, classical and complex segregation analysis, linkage analysis for Mendelian and complex diseases and quantitative traits, the detection of allelic associations, the estimation of heritability for multifactorial traits and path analysis

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease
Author : Roger N. Rosenberg,Juan M. Pascual
Publisher : Elsevier
Release Date : 2014-10-28
Category : Medical
Total pages :1464
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Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Fifth Edition provides a comprehensive introduction and reference to the foundations and key practical aspects relevant to the majority of neurologic and psychiatric disease. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, and related professionals, and for the neuroscience and neurology research community. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Every chapter has been thoroughly revised or newly commissioned to reflect the latest scientific and medical advances by an international team of leading scientists and clinicians. The contents have been expanded to include disorders for which a genetic basis has been recently identified, together with abundant original illustrations that convey and clarify the key points of the text in an attractive, didactic format. Previous editions have established this book as the leading tutorial reference on neurogenetics. Researchers will find great value in the coverage of genomics, animal models and diagnostic methods along with a better understanding of the clinical implications. Clinicians will rely on the coverage of the basic science of neurogenetics and the methods for evaluating patients with biochemical abnormalities or gene mutations, including links to genetic testing for specific diseases. Comprehensive coverage of the neurogenetic foundation of neurological and psychiatric disease Detailed introduction to both clinical and basic research implications of molecular and genetic understanding of the brain Detailed coverage of genomics, animal models and diagnostic methods with new coverage of evaluating patients with biochemical abnormalities or gene mutations

Genetic Politics

Genetic Politics
Author : Anne Kerr,Tom Shakespeare
Publisher : Unknown
Release Date : 2002
Category : Medical
Total pages :211
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"Genetic Politics explores the history of eugenics and the rise of contemporary genomics, identifying continuities and changes between the past and the present. The authors reject the two extreme positions that human genetics are either fatally corrupted by, or utterly immune from, eugenic influence. They argue that today's forms of genetic screening are far from equivalent to the eugenics of the past, but eugenics cannot simply be dismissed as bad science, or the product of totalitarian regimes, for its values and practices continue to shape genetics today."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved