November 29, 2020

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Research in Medical and Biological Sciences

Research in Medical and Biological Sciences
Author : Petter Laake,Haakon Breien Benestad
Publisher : Academic Press
Release Date : 2015-06-05
Category : Science
Total pages :512
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Research in Medical and Biological Sciences covers the wide range of topics that a researcher must be familiar with in order to become a successful biomedical scientist. Perfect for aspiring as well as practicing professionals in the medical and biological sciences, this publication discusses a broad range of topics that are common yet not traditionally considered part of formal curricula, including philosophy of science, ethics, statistics, and grant applications. The information presented in this book also facilitates communication across conventional disciplinary boundaries, in line with the increasingly multidisciplinary nature of modern research projects. Covers the breadth of topics that a researcher must understand in order to be a successful experimental scientist Provides a broad scientific perspective that is perfect for students with various professional backgrounds Contains easily accessible, concise material about diverse methods Includes extensive online resources such as further reading suggestions, data files, statistical tables, and the StaTable application package Emphasizes the ethics and statistics of medical and biological sciences

Research Methodology in the Medical and Biological Sciences

Research Methodology in the Medical and Biological Sciences
Author : Petter Laake,Haakon Breien Benestad,Bjorn Reino Olsen
Publisher : Academic Press
Release Date : 2007-11-05
Category : Science
Total pages :512
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Providing easy-to-access information, this unique sourcebook covers the wide range of topics that a researcher must be familiar with in order to become a successful experimental scientist. Perfect for aspiring as well as practicing professionals in the medical and biological sciences it discusses a broad range of topics that are common, yet not traditionally considered part of formal curricula. The information presented also facilitates communication across conventional disciplinary boundaries, in line with the increasingly multidisciplinary nature of modern research projects. Perfect for students with various professional backgrounds providing a broad scientific perspective Easily accessible, concise material makes learning about diverse methods achievable in today's fast-paced world

Biological and Medical Research in Space

Biological and Medical Research in Space
Author : David Moore,Peter Bie,Heinz Oser
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Science
Total pages :569
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Life Science studies in space were initially driven by the need to explore how man could survive spaceflight conditions; the effects of being launched un der high accelerations, exposed to weightlessness and radiation for different periods of time, and returned to Earth in safety. In order to substantiate the detailed knowledge of potentially adverse effects, many model experiments were launched using organisms which ranged from bacteria, plants, inverte brates, rodents and primates through to man. Although no immediate life threatening effects were found, these experiments can be considered today as the precursors to life science research in space. Many unexplained effects on these life forms were attributed to the condition of weightlessness. Most of them were poorly recorded, poorly published, or left simply with anecdotal information. Only with the advent of Skylab, and later Spacelab, did the idea emerge, and indeed the infrastructure permit, weightlessness to be considered as an ex tended tool for research into some fundamental mechanisms or processes as sociated with the effect of gravity on organisms at all levels. The initial hy pothesis to extrapolate from hypergravity through 1 x g to near 0 x g effects could no longer be retained, since many of the experiment results were seen to contradict the models or theories in the current textbooks of biology and physiology. The past decade has been dedicated primarily to exploratory research.

Quantitative Methods in Biological and Medical Sciences

Quantitative Methods in Biological and Medical Sciences
Author : H.O. Lancaster
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Science
Total pages :297
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My original intention was to write a history of medical statistics, used in its prewar sense, expanding the writings on the subject by Major Greenwood, from which I formed many of my ideas in the early days immediately after the Second World War. In later years, I decided that the scope of his works was narrower than what I think is appropriate now, for he was writing in an era before the acceptance and use of the Fisherian methods and he was probably not aware of the mathematization of many parts of biological theory. Further, the boundary between the medical and biological sciences has largely disappeared. Many texts have now been written on branches of the theory and practice inspired by R. A. Fisher (see §4. 13). I discuss the history of the use of quantitative methods in the biological sciences, defined after the style of Peller (1967) as that branch of science that uses a quantitative approach to, or quantitative logical reasoning on, or biology. The mathematical tech any issue having to do with medicine niques are various and not classified here. Within the book I use "biological sciences" to include medicine but use the longer phrase in its title to avoid misunderstandings as to content. Moreover, most of the experimental work carried out in medical research laboratories is performed on animals other than man.

Reproducibility in Biomedical Research

Reproducibility in Biomedical Research
Author : Erwin B. Montgomery
Publisher : Academic Press
Release Date : 2019-03-14
Category : Medical
Total pages :356
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Reproducibility in Biomedical Research: Epistemological and Statistical Problems explores the ideas and conundrums inherent in scientific research. It explores factors of reproducibility, including logic, distinguishing productive from unproductive irreproducibility, the scientific method, and the use of statistics. In multiple examples and six detailed case studies, the book demonstrates the misuse of logic resulting in unproductive irreproducibility, allowing researchers to develop their own logic and planning abilities. Biomedical researchers, clinicians, administrators of scientific institutions and funding agencies, journal editors, philosophers of science and medicine will find the arguments and explorations a valuable addition to their libraries. Considers the meaning and purpose of reproducibility to help design research Reviews famous case studies of alleged irreproducibility to determine if these could be reproducible Provides a theoretical aspect to practical issues surrounding research design and conduct

Bioinformatics Basics

Bioinformatics Basics
Author : Hooman H. Rashidi,Lukas K. Buehler
Publisher : CRC Press
Release Date : 1999-12-15
Category : Science
Total pages :200
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Scientists in the throes of research use an extensive data bank to access structural information on proteins and nucleic acids. Meanwhile, geneticists use a highly specialized form of software to analyze the hybridization pattern of DNA chips. The past decade has been tremendously successful for biotechnology and pharmaceutical industries. This success has been a result of astounding technical advancements in genome sequencing (genomics), protein identification (proteomics), and data analysis-collectively called bioinformatics. The exponential increase in computer processing and disk storage has served as a catalyst and been instrumental in the development of bioinformatics. Bioinformatics Basics: Applications in Biological Science and Medicine describes the origin of this field and the organization of public domain databases with an introductory tutorial for the services described. This book explains these services in a relatively simple fashion. Nevertheless, a biological background is necessary to understand and properly utilize the various software components and services described in this book. A basic biological background is also necessary for understanding the biological and medical significance of the collected data. Bioinformatics Basics is a fast growing field, and it will take some years for a stabilization to occur. Until then, hundreds of Internet sites allow us to search, compare, and manipulate this data in its relatively raw format. Bioinformatics Basics: Applications in Biological Science and Medicine concentrates on three major database clusters and relevant software tools that are maintained in the United States, Europe, and Japan, offering free access and analysis through the Internet.

Metabolomics for Biomedical Research

Metabolomics for Biomedical Research
Author : Jerzy Adamski
Publisher : Academic Press
Release Date : 2020-03-20
Category : Medical
Total pages :266
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Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research. Focuses on metabolomics in translational and medical research Provides basics for, and concepts of, contemporary translational personalized medicine research with metabolomics Brings the major recent progresses on design, analytics, biostatistics and bioinformatics relating to the success of metabolomics research

Research Films in Biology, Anthropology, Psychology, and Medicine

Research Films in Biology, Anthropology, Psychology, and Medicine
Author : Anthony Michaelis
Publisher : Elsevier
Release Date : 2012-12-02
Category : Photography
Total pages :506
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Research Films in Biology, Anthropology, Psychology, and Medicine is an encyclopedic account of the many uses of research films in the fields of biology, anthropology, psychology, and medicine. The book looks at cinemicrography, the making of human record films, and quantitative methods inherent in all scientific cinematography such as medical and X-ray cinematography. This volume is organized into three sections encompassing 10 chapters and begins by considering the definition of research film and scientific cinematography, touching on topics such as the advantages and limitations of scientific cinematography and methods used to preserve and store the research film. The next chapters discuss the fundamental principles of cinemicrography as a research tool; the value of cinematography in biological investigations, including the study of animal behavior; and the theoretical and practical considerations in the use of cinematography in the human sciences, such as anthropology, psychology, and psychiatry. The book also methodically introduces the reader to medical applications of cinematography and the techniques of X-ray cinematography, and then concludes with relevant examples of the use of cinematography in medical research and diagnosis. This book is a valuable resource for scientists and cinematographers.

The Common Marmoset in Captivity and Biomedical Research

The Common Marmoset in Captivity and Biomedical Research
Author : Robert P. Marini,Lynn M. Wachtman,Suzette D. Tardif,Keith Mansfield,James G. Fox
Publisher : Academic Press
Release Date : 2018-11-19
Category : Science
Total pages :570
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The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset (Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such as macaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate model to study a number of poorly understood disorders, like autism. Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications Includes contributions from renowned and international authors and editors Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series

Interpreting Biomedical Science

Interpreting Biomedical Science
Author : Ülo Maiväli
Publisher : Academic Press
Release Date : 2015-06-12
Category : Science
Total pages :416
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Interpreting Biomedical Science: Experiment, Evidence, and Belief discusses what can go wrong in biological science, providing an unbiased view and cohesive understanding of scientific methods, statistics, data interpretation, and scientific ethics that are illustrated with practical examples and real-life applications. Casting a wide net, the reader is exposed to scientific problems and solutions through informed perspectives from history, philosophy, sociology, and the social psychology of science. The book shows the differences and similarities between disciplines and different eras and illustrates the concept that while sound methodology is necessary for the progress of science, we cannot succeed without a right culture of doing things. Features theoretical concepts accompanied by examples from biological literature Contains an introduction to various methods, with an emphasis on statistical hypothesis testing Presents a clear argument that ties the motivations and ethics of individual scientists to the success of their science Provides recommendations on how to safeguard against scientific misconduct, fraud, and retractions Arms young scientists with practical knowledge that they can use every day

Biotechnology in Medical Sciences

Biotechnology in Medical Sciences
Author : Firdos Alam Khan
Publisher : CRC Press
Release Date : 2014-05-08
Category : Medical
Total pages :495
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As the field of medical biotechnology grows with new products and discoveries, so does the need for a holistic view of biotechnology in medicine. Biotechnology in Medical Sciences fulfills that need by delivering a detailed overview of medical biotechnology as it relates to human diseases and epidemiology, bacteriology and antibiotics, virology and vaccines, immunology and monoclonal antibodies, recombinant DNA technology and therapeutic proteins, stem cell technology, tissue engineering, molecular diagnostics and forensic science, gene therapy, synthetic biology and nanomedicine, pharmacogenomics, bioethics, biobusiness and intellectual property rights, and career opportunities. Organized to follow the chronology of major medical biotechnology research, breakthroughs, and events, this first-of-its-kind text: Covers all aspects of medical biotechnology, from labs to clinics and basic to advanced applications Describes historical perspectives and modern discoveries in medical biotechnology Explains how various biotechnology products are used to treat and prevent disease Discusses the tools and techniques currently employed in medical biotechnology Includes a bibliography at the end of each chapter to encourage further study Complete with colorful illustrations and examples, Biotechnology in Medical Sciences provides a comprehensive yet accessible treatment of this growing field.

Advances in Biological Science Research

Advances in Biological Science Research
Author : Surya Nandan Meena,Milind Naik
Publisher : Academic Press
Release Date : 2019-05-17
Category : Science
Total pages :580
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Advances in Biological Science Research: A Practical Approach provides discussions on diverse research topics and methods in the biological sciences in a single platform. This book provides the latest technologies, advanced methods, and untapped research areas involved in diverse fields of biological science research such as bioinformatics, proteomics, microbiology, medicinal chemistry, and marine science. Each chapter is written by renowned researchers in their respective fields of biosciences and includes future advancements in life science research. Discusses various research topics and methods in the biological sciences in a single platform Comprises the latest updates in advanced research techniques, protocols, and methods in biological sciences Incorporates the fundamentals, advanced instruments, and applications of life science experiments Offers troubleshooting for many common problems faced while performing research experiments

Research Training in the Biomedical, Behavioral, and Clinical Research Sciences

Research Training in the Biomedical, Behavioral, and Clinical Research Sciences
Author : National Research Council,Policy and Global Affairs,Board on Higher Education and Workforce,Committee to Study the National Needs for Biomedical, Behavioral, and Clinical Research Personnel
Publisher : National Academies Press
Release Date : 2011-02-28
Category : Medical
Total pages :206
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Comprehensive research and a highly-trained workforce are essential for the improvement of health and health care both nationally and internationally. During the past 40 years the National Research Services Award (NRSA) Program has played a large role in training the workforce responsible for dramatic advances in the understanding of various diseases and new insights that have led to more effective and targeted therapies. In spite of this program, the difficulty obtaining jobs after the postdoc period has discouraged many domestic students from pursuing graduate postdoc training. In the United States, more than 50 percent of the postdoc workforce is made up of individuals who obtained their Ph.D.s from other countries. Indeed, one can make a strong argument that the influx of highly trained and creative foreigners has contributed greatly to U.S. science over the past 70 years. Research Training in the Biomedical, Behavioral, and Clinical Research Sciences discusses a number of important issues, including: the job prospects for postdocs completing their training; questions about the continued supply of international postdocs in an increasingly competitive world; the need for equal, excellent training for all graduate students who receive NIH funding; and the need to increase the diversity of trainees. The book recommends improvements in minority recruiting, more rigorous and extensive training in the responsible conduct of research and ethics, increased emphasis on career development, more attention to outcomes, and the requirement for incorporating more quantitative thinking in the biomedical curriculum.

Principles of Translational Science in Medicine

Principles of Translational Science in Medicine
Author : Martin Wehling
Publisher : Academic Press
Release Date : 2015-04-02
Category : Science
Total pages :364
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Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

Biodiversity and Biomedicine

Biodiversity and Biomedicine
Author : Munir Ozturk,Dilfuza Egamberdieva,Milica Pešić
Publisher : Academic Press
Release Date : 2020-07-15
Category : Science
Total pages :608
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Biodiversity and Biomedicine: Our Future provides a new outlook on Earth’s animal, plant, and fungi species as vital sources for human health treatments. While there are over 10 million various species on the planet, only 2 million have been discovered and named. This book identifies modern ways to incorporate Earth’s species into biomedical practices and emphasizes the need for biodiversity conservation. Written by leading biodiversity and biomedical experts, the book begins with new insights on the benefits of biologically active compounds found in fungi and plants, including a chapter on the use of wild fruits as a treatment option. The book goes on to discuss the roles of animals, such as amphibians and reptiles, and how the threatened presence of these species must be reversed to conserve biodiversity. It also discusses marine organisms, including plants, animals, and microbes, as essential in contributing to human health. Biodiversity and Biomedicine: Our Future is a vital source for researchers and practitioners specializing in biodiversity and conservation studies. Students in natural medicine and biological conservation will also find this useful to learn of the world’s most bio-rich communities and the molecular diversity of various species. Presents new developments in documenting and identifying species for biodiversity conservation and ethical considerations for biodiversity research Examines biodiversity as an irreplaceable resource for biomedical breakthroughs using available species for medical research Discusses challenges and opportunities for biodiversity protection and research in biosphere reserves