June 17, 2021

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Sleep, Epilepsies, and Cognitive Impairment

Sleep, Epilepsies, and Cognitive Impairment
Author : Peter Halasz,Anna Szucs
Publisher : Academic Press
Release Date : 2018-02-26
Category : Medical
Total pages :174
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Translational research connects science and clinical medicine from "the bench to the bedside." In Sleep, Epilepsies and Cognitive Impairment, the authors look back from the bedside to the brain function underlying clinical symptoms and reveal mechanisms explored by contemporary neuroimaging and signal analysis in the overlapping fields of sleep and epilepsy. This book will help the reader to see epilepsy from a new viewpoint. The common pathophysiology binding together the diverse manifestations of epilepsies is the exaggeration of plastic functions of the brain involving the hippocampus, the non-specific thalamocortical system and the perisylvian cognitive network. Epileptic derailment seems to be the price for the latest achievements of the mammal and human brain; namely the highly developed ability to change and learn. The contemporary results of sleep research provide new viewpoints to explain why sleep and epilepsy are bedfellows. Converging evidence supports the concept that one of the most important biological roles of NREM sleep is the renewal of synaptic balance ensuring learning ability from one day to the next and consolidation of new memories. Epilepsy and NREM sleep use overlapping structures and functions, therefore epilepsy beginning in early childhood may interfere with sleep plastic functions. NREM sleep, which affects original learning and memory, may become the hidden source of chronic cognitive impairment when epilepsy occurs during sleep and blocks the plastic processes. Sleep, Epilepsies and Cognitive Impairment abandons the academic classification of epilepsy by following the system epilepsy concept, binding major epilepsies with structures and functions of physiological brain systems. It tries to show within this system the close interrelationship between sleep, epilepsy and cognition. Neuroscientists, clinical epileptologists and neurologists interested in brain processes underlying brain plasticity, sleep and epilepsy will find this book thought provoking. It offers good "brain-gymnastics" for reconsidering the ideas on epilepsy. It provides contemporary knowledge about the neurophysiological and functional anatomical background of major epilepsies Treats major epilepsies as system epilepsies of brain networks Reveals the interrelationship of sleep, epilepsy and cognitive impairment showing how epileptic manifestations became facilitated in NREM sleep and interferes with sleep plastic functions

Encephalopathy related to Status Epilepticus during slow Sleep

Encephalopathy related to Status Epilepticus during slow Sleep
Author : Guido Rubolli,Carlo-Alberto Tassinari
Publisher : John Libbey Eurotext
Release Date : 2019-12-05
Category : Medical
Total pages :140
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In the last years, clinical data, neurophysiological and imaging investigations, as well as genetic studies have renewed the interest on ESES. In addition, experimental findings from sleep research have opened fascinating perspectives on some possible pathophysiological mechanisms involved in this condition. These issues are presented and discussed in this book by clinicians, neurophysiologists, sleep physiologists and geneticists. They all have been working on ESES with the aim to provide an updated overview of this special syndrome in the light of recent research.

Pediatric Neurology Part I

Pediatric Neurology Part I
Author : Patrick Van Bogaert
Publisher : Elsevier Inc. Chapters
Release Date : 2013-04-24
Category : Medical
Total pages :892
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Epileptic encephalopathy with continuous spike-waves during slow-wave sleep (CSWS) is a spectrum of epileptic conditions best defined by the association of cognitive or behavioral impairment acquired during childhood and not related to another factor other than the presence of abundant interictal epileptiform discharges (IED) during sleep, which tend to diffuse over the whole scalp. It is part of the childhood focal epileptic syndromes, some cases being idiopathic and overlapping with benign rolandic epilepsy, and others being symptomatic of a structural brain lesion. Landau–Kleffner syndrome (LKS) is a particular presentation where acquired aphasia is the core symptom. Clinical, neurophysiological, and cerebral glucose metabolism data support the hypothesis that IED play a prominent role in the cognitive deficits by interfering with the neuronal networks at the site of the epileptic foci but also at distant connected areas. Therefore, the treatment should aim to suppress IED. This may be achieved using conventional antiepileptic drugs, but corticosteroids seem to have more pronounced and sustained efficacy. Outcome for epilepsy is usually good, CSWS being an age-dependent EEG pattern, whereas outcome for cognition, language, and behavior is variable. Rehabilitation represents an important part of the treatment and visual forms of language should be encouraged in children with LKS.

The Epilepsies

The Epilepsies
Author : Chrysostomos P. Panayiotopoulos
Publisher : Bladon Medical Pub
Release Date : 2005
Category : Medical
Total pages :541
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The Epilepsies: Seizures, Syndromes and Management is the latest work from one of the world's leading experts and offers an exhaustive account of the classification and management of epileptic disorders. In thirteen chapters, Dr Panayiotopoulos gives clear and didactic guidance on the diagnosis, treatment and ongoing management of the full spectrum of epileptic syndromes with an insight and perception that only he can bring to the subject.This text is published in full colour throughout and is complemented by a pharmacopoeia and CD ROM with patient video-EEGs. An attractive, clear page layout and the accompanying supplementary material help the reader to easily identify the key components of each disorder, syndrome and seizure. Drawing on the author's outstanding collection of video-EEGs the accompanying CD ROM is cross-referenced within the text thus providing the reader with both a clinical and visual description of the various epileptic disorders and further aiding diagnosis.

Cognitive Dysfunction in Children with Temporal Lobe Epilepsy

Cognitive Dysfunction in Children with Temporal Lobe Epilepsy
Author : Alexis Arzimanoglou,Albert Aldenkamp,Helen Cross,Maryse Lassonde
Publisher : John Libbey Eurotext
Release Date : 2005
Category :
Total pages :289
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Much has been written about the cognitive function of children with epilepsy but despite there being extensive study of the neuropsychological status of adults with intractable temporal lobe epilepsy, it has been more limited in children. Although cognitive development in children is influenced by similar factors to adults, the role of early damage, modification of cerebral organisation and interruption of the learning process are also likely to be important. Devoted to cognitive function and dysfunction in children with temporal lobe epilepsy, this book highlights those domains that demand further research and those for which immediate established techniques for a better global care can be undertaken.

Encephalopathy related to status epilepticus during slow sleep

Encephalopathy related to status epilepticus during slow sleep
Author : Guido Rubboli,Carlo Alberto Tassinari
Publisher : Unknown
Release Date : 2019-12-07
Category :
Total pages :138
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Encephalopathy with Electrical Status Epilepticus during Sleep (ESES) was described almost 50 years ago; however its clinical spectrum and its boundaries, the diagnostic criteria, the pathophysiology and the therapeutic management are still debated. In the last years, clinical data, neurophysiological and imaging investigations, as well as genetic studies have renewed the interest on ESES. In addition, experimental findings from sleep research have opened fascinating perspectives on some possible pathophysiological mechanisms involved in this condition. These issues are presented and discussed in this book by clinicians, neurophysiologists, sleep physiologists and geneticists. They all have been working on ESES with the aim to provide an updated overview of this special syndrome in the light of recent research.

Epileptic Seizures

Epileptic Seizures
Author : Hans Lüders,Hans O. Luders,Soheyl Noachtar
Publisher : Unknown
Release Date : 2000
Category : Medical
Total pages :796
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Aims to present an overview of the clinical semiology of epileptic seizures. This book/CD ROM package is meant for the practicing neurologist, who must recognize, diagnose, and treat the patient with epileptic seizures. The CD ROM demonstrates typical symptoms of different seizure types.

The Contribution of Sleep to Cognitive Function in Children with Epilepsy

The Contribution of Sleep to Cognitive Function in Children with Epilepsy
Author : Samantha Yuen-Sum Chan
Publisher : Unknown
Release Date : 2017
Category :
Total pages :129
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Neuropsychology of Childhood Epilepsy

Neuropsychology of Childhood Epilepsy
Author : Isabelle Jambaqué,Maryse Lassonde,Olivier Dulac
Publisher : Springer Science & Business Media
Release Date : 2006-04-11
Category : Medical
Total pages :290
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This book is devoted to the neuropsychological description of childhood epilepsy, a neurolo- cal condition that constitutes one of the most prevalent forms of chronic and disabling childhood illnesses. Indeed, one child out of 20 experiences one or more seizures before the age of 5, and one in a hundred develops epilepsy as a chronic disorder. Approximately half of these children with epilepsy display academic difficulties and/or behavioral disorders. Moreoever, it is now believed that a sizable proportion of children with learning disability suffer from undiagnosed epilepsy. While a great number of textbooks have been devoted to various medical aspects of chi- hood epilepsy (diagnosis, genetics, etiology, drug and surgical treatment, etc.), there have been no comprehensive accounts of the cognitive consequences of this condition. Advance of medical knowledge has shown that childhood epilepsy should not be considered as a single disorder but encompasses a whole range of different conditions that exhibit specific clinical EEG and outcome characteristics. It is not becoming apparent that these various clinical entities have different cognitive expression that yet need to be specified. The purpose of this book is to provide a complete up-to-date analysis of this multi-faceted pathology.

Dravet syndrome

Dravet syndrome
Author : Charlotte Dravet,Renzo Guerrini
Publisher : John Libbey Eurotext
Release Date : 2013-09-18
Category :
Total pages :129
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Dravet syndrome is a rare and severe type of epilepsy. “Severe myoclonic epilepsy in infancy” was first described in 1978 by Charlotte Dravet, who observed common features: onset in the first year of life, fever sensitivity, multiple seizure types, often including myoclonic seizures, and cognitive deterioration. Subsequent descriptions contributed to delineating a newly recognised epilepsy syndrome. Renzo Guerrini contributed to the knowledge of the genetic basis and response to anti epileptic drugs of Dravet syndrome. New molecules have emerged, and studies on cognitive development have qualified the impairment. Families’ associations have also contributed to a better knowledge of the syndrome. Charlotte Dravet and Renzo Guerrini present here the state of current knowledge about this epilepsy type. This book aims to provide more information on the syndrome to those neurologists, child neurologists, and pediatricians confronted with infants, children and adults who either have or are suspected to have Dravet syndrome. Even if significant gaps in our understanding of the syndrome remain, the authors hope this contribution may assist in the understanding of the disease and optimization of treatments.

Epilepsy Abstracts

Epilepsy Abstracts
Author : Anonim
Publisher : Unknown
Release Date : 1986
Category : Epilepsy
Total pages :129
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Benign Localized and Generalized Epilepsies of Early Childhood

Benign Localized and Generalized Epilepsies of Early Childhood
Author : R. Degen,Fritz E. Dreifuss
Publisher : Elsevier Science Limited
Release Date : 1992
Category : Medical
Total pages :230
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This volume is arranged so as to review the classification of the Epilepsies, Epileptic Syndromes and Related Disorders (International League Against Epilepsy) and then the individual groups of benign epilepsies including benign childhood epilepsy with centrotemporal spike discharges, benign epilepsy in childhood with occipital paroxysms and epilepsy in slow wave sleep. Also included is a section followed by a discussion of the benign generalized epilepsies and the borderland between them and the more sinsiter conditions. The definition of the syndrome has received further impetus by the discovery that some of the syndromes represented in the primary or idiopathic epilepsies have a distinct place in the human genome with a putative localization of juvenile myoclonic epilepsy on chromosome 6 and of benign familial neonatal convulsions on chromosome 20.

Neuropsychology in the Care of People with Epilepsy

Neuropsychology in the Care of People with Epilepsy
Author : Christoph Helmstaedter, Bruce Hermann, Maryse Lassonde, Philippe Kahane, Alexis Arzimanoglou
Publisher : John Libbey Eurotext
Release Date : 2011-01-01
Category : Epilepsy
Total pages :338
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Having appeared in the 1930s in Montreal, standardised neuropsychological evaluation has become an essential tool in the clinical diagnosis and evaluation of surgical epileptic patients. Nevertheless, despite great progress over the last 20 to 30 years in the diagnosis and medical treatment of epilepsy, clinical neuropsychology still remains largely associated with surgical epilepsy, particularly surgery of the temporal lobe. Clinical neurology has still not managed to clear a way in the daily practice with patients with all types of epilepsy despite significant advances in cognitive neuroscience and a large number of clinical studies on epilepsy and cognition. How is it that there are only rarely major advances in the field of clinical neuropsychology? It has long been time for this question to be asked, and for an attempt to be made to bring about changes. This was the aim of the Toronto workshop and the result of this book. Every approach was debated, providing important elements to reflect on and allowing a great forum for exchanges. This book includes the communications from the main participants and comments from some others on specific subjects.

Social Cognitive Impairment in People with Epilepsy

Social Cognitive Impairment in People with Epilepsy
Author : Man-Kiu Ma,馬文嬌
Publisher : Open Dissertation Press
Release Date : 2017-01-26
Category :
Total pages :129
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This dissertation, "Social Cognitive Impairment in People With Epilepsy" by Man-kiu, Ma, 馬文嬌, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Epilepsy is a highly prevalent neurological disorder affecting people from all walks of life. Psychosocial adjustment and psychological morbidity have been longstanding challenges for people with this clinical diagnosis. However, very little is known about the psychosocial correlates of psychological morbidity, such as anxiety and depression, among people with epilepsy in Hong Kong. Previous clinical studies suggest social cognitive impairment may contribute to the poor psychosocial integration of people with epilepsy. An important aspect of social cognition is the ability to attribute mental states to others so as to understand their behavior, desires, and intentions. This prerequisite for successful social interactions is termed mentalizing. This thesis reports two studies conducted to examine the psychosocial correlates of psychological morbidity among people with epilepsy, and their mentalizing ability with regard to the neuropsychological basis of mentalizing deficits that are specific to this neurological disorder. Study 1 examines the association of psychological morbidity with a broad array of personality traits and social skills in a sample of 54 local Chinese people with epilepsy. Participants completed the Temperament and Character Inventory (TCI), the Social Performance Survey Schedule (SPSS), and the Hospital Anxiety and Depression Scale (HADS) via semi-structured interviews. The findings showed that, independent of demographic and medical variables and perceived illness-related impact, three personality traits (harm avoidance temperament, self-directedness, and cooperation) and two subscales of interpersonal behaviors (both positive and negative social skills) are significant psychosocial predictors of adjustment among Chinese people with epilepsy. Study 2 examines the neuropsychological basis of mentalizing deficits in people with epilepsy. Thirty-nine right-handed local Chinese people with epilepsy and 38 matched healthy controls were recruited for this study. The eyes test and the faux pas test were employed to study the decoding and reasoning stages of mentalizing, respectively. The findings showed that, relative to the healthy controls, the participants with epilepsy were impaired in decoding and reasoning about the affective aspect of social materials; and at the same time, they were impaired in reasoning about the cognitive aspects of others' mental states-that is, in inferring intentionality. Such a pattern of mentalizing deficits suggests a wider structural abnormality that may be implicated in the brains of people with epilepsy. In conclusion, epilepsy is associated with social cognitive impairment in emotion recognition and intentionality inference, involving both decoding and reasoning about the affective and cognitive aspects of others' mental state, which may predispose people with epilepsy to maladaptive psychosocial adjustment and functioning. The significance and implications of the results are discussed. DOI: 10.5353/th_b4819925 Subjects: Epileptics - Psychology

The Surgical Management of Epilepsy

The Surgical Management of Epilepsy
Author : Allen R. Wyler,Bruce P. Hermann
Publisher : Butterworth-Heinemann Medical
Release Date : 1994
Category : Medical
Total pages :277
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* Comprehensive refernce covering all aspects of epilepsy surgery * Contributions from 31 prominent, international neurologists and neurosurgeons