November 28, 2020

Download Ebook Free Spinal Cord Injury (SCI) Repair Strategies

Spinal Cord Injury (SCI) Repair Strategies

Spinal Cord Injury (SCI) Repair Strategies
Author : Giuseppe Perale,Filippo Rossi
Publisher : Woodhead Publishing
Release Date : 2019-10-30
Category : Medical
Total pages :346
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Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma
Author : Michael G. Fehlings,Brian Kwon,Alexander R. Vaccaro,F. Cumhur Oner
Publisher : Academic Press
Release Date : 2020-12-01
Category : Medical
Total pages :400
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Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma. Contains contributions by international authors Covers recent clinical trial advancements and findings and updates on ongoing trials Presents an overview of clinical practice guidelines for the management of traumatic spinal cord injury featured Provides the reader with insights regarding the translation of research from bench to bedside and the skills needed to understand the translational pathway using real-life examples

Promoting Neuroplasticity to Repair the Injured Spinal Cord

Promoting Neuroplasticity to Repair the Injured Spinal Cord
Author : Nina Weishaupt
Publisher : Unknown
Release Date : 2013
Category : Neuroplasticity
Total pages :272
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This thesis explores strategies to promote neuronal plasticity in a rat model of cervical spinal cord injury (SCI) in an effort to achieve improved recovery of skilled forelimb use. I focused on investigating how motor pathways disrupted by an SCI may connect to spared, lesion-bridging relay pathways to re-establish communication with target regions below the injury level. In chapter 2, I attempted to promote a detour for the cervically injured corticospinal tract (CST) via spared reticulospinal tract (RtST) axons with a combined treatment including the neurotrophins BDNF, NT-3 and rehabilitative training. Although anatomical evidence for the desired rewiring was not obtained, I found a synergistic effect of BDNF treatment and training on recovery of skilled forelimb reaching. No effect of NT-3 administered rostral to the SCI was evident. The experiment in chapter 3 was designed to answer the question whether NT-3-induced CST collateral growth rostral to an SCI can be facilitated by systemic immune activation. Results indicate that NT-3 expression can promote collateral growth from the injured CST, irrespective of immune activation. Since results from chapter 2 did not shed light on the previously suggested role of the RtST in recovery of hand/paw function after cervical SCI, I next examined whether the mostly spared RtST responds to SCI with changes in its anatomical projection pattern. While collateral projections were unchanged rostral to the SCI, I observed a marked withdrawal of collaterals from grey matter regions directly caudal to the SCI. Results from chapter 2 combined with previous reports indicate that task-specific training does often not translate into untrained tasks and may even result in undesired side effects. To elucidate the functional relationship between trained tasks further, I next investigated how training the primarily affected forelimb (PAF) and/or the less affected forelimb (LAF) after unilateral cervical SCI influences performance outcomes for each limb. Results point towards training tasks competitively recruiting available neuronal "hardware". This work identifies promising leads for promoting plasticity of important motor tracts after SCI, and also points out targets for optimization of strategies employed. These new insights contribute to the exploration of urgently needed repair strategies for SCI.

Neurobiology of Spinal Cord Injury

Neurobiology of Spinal Cord Injury
Author : Robert G. Kalb,Stephen M. Strittmatter
Publisher : Springer Science & Business Media
Release Date : 1999-10-22
Category : Medical
Total pages :284
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Distinguished researchers review the latest scientific understanding of spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function. The authors examine the role of intracellular Ca2+ in neuronal death, the possibility of spinal learning, growth-promoting molecules for regenerating neurons, and the biochemistry and cell biology of microtubules. Among the treatment possibilities discussed are cell transplantation strategies beyond the use of fetal spinal cord tissue, remyelination in spinal cord demyelination models, high steroid therapy immediately after SCI, and the mixed use of anti- and proinflammatories. Comprehensive and highly promising, Neurobiology of Spinal Cord Injury summarizes and integrates the great progress that has been made in understanding and combating the paralysis that follows spinal cord injury.

Biomimetic Materials And Design

Biomimetic Materials And Design
Author : Angela Dillow,Anthony Lowman
Publisher : CRC Press
Release Date : 2002-08-28
Category : Medical
Total pages :696
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Detailing techniques in wound healing and reconstruction, this reference describes the mechanisms and architecture of biological systems to formulate and design natural and synthetic compounds, degradable and non-degradable scaffolds, and targeted drug delivery devices. It offers strategies to control adhesive interactions, elicit specific cellular responses, and improve the biocompatibility, performance, and durability of prosthetic materials. Covering advances in the field, the book discusses the effect of topographical features on cell behaviors such as orientation, adhesion, migration, proliferation, and differentation.

Spinal Cord Injury Rehabilitation

Spinal Cord Injury Rehabilitation
Author : Edelle Field-Fote
Publisher : F.A. Davis
Release Date : 2009-03-26
Category : Medical
Total pages :500
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One of the world’s leading authorities in spinal cord injury, and a participant in the Human Brain Project brings you an evidenced-based guide to the state-of-the-art in spinal cord rehabilitation. She has assembled an expert team of clinicians, each with expertise in the content areas they address. Their work encompasses all of the new scientific knowledge and technological advances practitioners need to know to determine the most effective rehabilitation interventions for each patient and to attain maximum restoration of function in individuals with SCI.

Spinal Cord Injury

Spinal Cord Injury
Author : Joost Verhaagen,John W. McDonald III
Publisher : Newnes
Release Date : 2012-12-31
Category : Medical
Total pages :656
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Handbook of Clinical Neurology: Spinal Cord Injury summarizes advances in the clinical diagnosis, monitoring, prognostication, treatment, and management of spinal cord injuries. More specifically, it looks at new and important developments in areas such as high-resolution noninvasive neuroimaging, surgery, and electrical stimulation of motor, respiratory, bladder, bowel, and sexual functions. It also reviews the latest insights into spontaneous regeneration and recovery of function following rehabilitation, with emphasis on novel therapeutic strategies, such as gene therapy, transcranial stimulation, brain-machine interfaces, pharmacological approaches, molecular target discovery, and the use of olfactory ensheathing cells, stem cells, and precursor cells. Organized in five sections, the book begins with an overview of the development, maturation, biomechanics, and anatomy of the spinal cord before proceeding with a discussion of clinical diagnosis and prognosis as well as natural recovery, ambulation, and function following spinal cord injury. It then examines clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury; medical, surgical and rehabilitative management of spinal cord trauma; and some new approaches for improving recovery in patients, including restoration of function by electrical stimulation, locomotor training, and the use of robotics. Other chapters cover cell transplantation, artificial scaffolds, experimental pharmacological interventions, and molecular and combinatorial strategies for repairing the injured spinal cord. This volume should be of interest to neuroscience and clinical neurology research specialists and practicing neurologists. Comprehensive coverage of the latest scientific understanding of spinal cord injuries Detailed coverage of current treatment best practices and potential future treatments Connects leading edge research programs to future treatment opportunities

Regenerative Biology of the Spine and Spinal Cord

Regenerative Biology of the Spine and Spinal Cord
Author : Rahul Jandial,Mike Y. Chen
Publisher : Springer Science & Business Media
Release Date : 2013-04-13
Category : Medical
Total pages :215
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Editors hope that Regenerative Biology of the Spine and Spinal Cord appeals to the nostalgic sentiments of investigators and intellectuals in that it can be held in hand and provide a broad survey of leading edge science. At the same time its chapters can be digitally acquired for those established in the field to refine particular knowledge interests or gaps. Most importantly, we ask the reader, whomever that may be, to peruse without prejudice as countless more chapters will have been written before total spinal regeneration is achieved.

Essentials of Spinal Cord Injury Medicine

Essentials of Spinal Cord Injury Medicine
Author : Yannis Dionyssiotis
Publisher : BoD – Books on Demand
Release Date : 2018-06-13
Category : Medical
Total pages :166
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Spinal cord injury is a severe condition leading to serious neurological dysfunctions and changes a person's life in a sudden way. Understanding the pathophysiology of spinal cord injury will improve the prognosis and reintegration to the society of spinal cord-injured subjects. The book Essentials in Spinal Cord Injury Medicine includes seven chapters with valuable information addressing hot topics related to spinal cord injury, ranging from pathophysiology, nontraumatic spinal cord injury, complications to exoskeletons, and research therapies with mesenchymal stem cells. The book could be a valued reference for physiatrists, neurosurgeons, orthopedic surgeons, neurologists and physical therapists.

Spinal Cord Medicine, Second Edition

Spinal Cord Medicine, Second Edition
Author : Christopher M. Bono, MD,Diana D. Cardenas, MD, MHA,Frederick S. Frost, MD,Margaret C. Hammond, MD,Laurie B. Lindblom, MD,Inder Parkash, MD, MS, FRCS, FACS,Stevens A. Stiens, MD, MS,Robert M. Woolsey, MD
Publisher : Demos Medical Publishing
Release Date : 2010-03-19
Category : Medical
Total pages :560
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A Doody's Core Title 2012 The thoroughly revised Second Edition of this authoritative reference continues to define the standard of care for the field of spinal cord medicine. Encompassing all of the diseases and disorders that may a!ect the proper functioning of the spinal cord or spinal nerves, this comprehensive volume provides a state of the art review of the principles of care and best practices for restoring function and quality of life to patients with spinal cord injuries. Expert contributors from multiple disciplines cover topics ranging from acute medical and surgical management of specific problems to cutting-edge research, bladder, bowel and sexual dysfunction, neurologic and musculoskeletal issues, advanced rehabilitation techniques and technologies, functional outcomes, and psychosocial care. While comprehensive in scope, Spinal Cord Medicine offers practical guidance for physicians and other health care professionals involved in the management of individuals with SCI, multiple sclerosis, and other spinal cord disorders. The Second Edition has been completely updated to fully reflect current science and practice. Each section has been re-ordered to better present information and the Second Edition brings in many new authors and topics, more diagrams, illustrations, and tables to solidify concepts, and contains 18 entirely new chapters. Spinal Cord Medicine: Principles and Practice, Second Edition, reflects the breadth and depth of this multi-faceted specialty. Involving over 150 authors from more than 20 fields of medicine, it is a trusted reference for anyone who works with spinal cord patients and strives to deliver superior clinical care and improve outcomes.

Gene Therapy of the Central Nervous System: From Bench to Bedside

Gene Therapy of the Central Nervous System: From Bench to Bedside
Author : Michael G. Kaplitt,Matthew During
Publisher : Gulf Professional Publishing
Release Date : 2006
Category : Medical
Total pages :355
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Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis. * Presents gene transfer technologies with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells * Discusses preclinical areas that are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis * Includes "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use

Practical Management of Head and Neck Injury

Practical Management of Head and Neck Injury
Author : Jeffrey Rosenfeld
Publisher : Elsevier Health Sciences
Release Date : 2012-10-31
Category : Medical
Total pages :404
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Category Winner 2013 - Tertiary Education (Wholly Australian) Student Resource, Australian Publishers Association – Australian Educational Publishing Awards 2013. Practical Management of Head and Neck Injury is a unique textbook which comprehensively covers the patient journey from injury to the rehabilitation phase. It includes diagnosis and management of head and neck injury with additional chapters on prognosis and special conditions including head injury in sport, the elderly, children, pregnant women, penetrating head injury, spine and spinal cord injury and brain death. It describes an integrated approach to care from all the relevant specialties with Australian, UK and US experts contributing to many chapters. The book will be of interest to junior doctors, specialist trainees and specialists in emergency medicine, surgery, neurosurgery, orthopaedics, ENT, maxillofacial surgery, neurology, ophthalmology, anaesthesia and intensive care as well as medical students, nurses, paramedics and remote and rural practitioners. The complete management of patients with head and neck trauma, from the accident scene through to rehabilitation Safe, practical tips to assist the non-neurosurgeon in managing head injuries and preventing secondary brain injury—a major concern for emergency and pre-hospital medical personnel All aspects of neck trauma covered, including the management of cervical spine injury Detailed discussion of topics such as the classification of brain injury, concussion in sport, head injuries in children and the elderly, penetrating head injuries and the prognosis of head injury The operative surgery of head and neck trauma outlined for the non-surgeon Contributions from a wide range of specialists, both from Australia and overseas Integration of neurosurgery with ear, nose and throat (ENT) surgery, maxillofacial surgery, ophthalmology and spinal orthopaedics Basic principles of relevant anatomy and pathophysiology, each covered in a separate chapter

Advances in Nervous System Trauma Research and Treatment: 2013 Edition

Advances in Nervous System Trauma Research and Treatment: 2013 Edition
Author : Anonim
Publisher : ScholarlyEditions
Release Date : 2013-06-21
Category : Medical
Total pages :254
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Advances in Nervous System Trauma Research and Treatment: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Craniocerebral Trauma. The editors have built Advances in Nervous System Trauma Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Craniocerebral Trauma in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Nervous System Trauma Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Handbook of Innovations in Central Nervous System Regenerative Medicine

Handbook of Innovations in Central Nervous System Regenerative Medicine
Author : António Salgado
Publisher : Elsevier
Release Date : 2020-06-10
Category : Medical
Total pages :710
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Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance Discusses the limitations of present therapies used in the clinics Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path

Axon Growth and Regeneration:

Axon Growth and Regeneration:
Author : Anonim
Publisher : Academic Press
Release Date : 2012-12-31
Category : Science
Total pages :272
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Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research. Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered. All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist