November 29, 2020

Download Ebook Free Stellate Cells In Health And Disease

Stellate Cells in Health and Disease

Stellate Cells in Health and Disease
Author : Chandrashekhar Gandhi,Massimo Pinzani
Publisher : Academic Press
Release Date : 2015-04-10
Category : Science
Total pages :336
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Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.

Cooperation of Liver Cells in Health and Disease

Cooperation of Liver Cells in Health and Disease
Author : Z. Kmiec
Publisher : Springer Science & Business Media
Release Date : 2013-06-29
Category : Science
Total pages :151
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It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Exam Prep for: Stellate Cells in Health and Disease

Exam Prep for: Stellate Cells in Health and Disease
Author : Anonim
Publisher : Unknown
Release Date : 2020
Category :
Total pages :129
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Vitamin A in Health and Disease

Vitamin A in Health and Disease
Author : Rune Blomhoff
Publisher : CRC Press
Release Date : 1994-02-01
Category : Medical
Total pages :704
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This text details the metabolism of vitamin A and the mechanisms of action of vitamin A and the provitamin A carotenoids. It presents up-to-date information on the critical role vitamin A plays in vision, reproduction, foetal development, and the regulation and proliferation of cells. In addition, the book investigates evidence relating vitamin A intake to lung, breast, colon, rectal and prostate cancer.

Discoidin Domain Receptors in Health and Disease

Discoidin Domain Receptors in Health and Disease
Author : Rafael Fridman,Paul H. Huang
Publisher : Springer
Release Date : 2016-08-13
Category : Medical
Total pages :355
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The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.

Dipeptidyl Aminopeptidases in Health and Disease

Dipeptidyl Aminopeptidases in Health and Disease
Author : Martin Hildebrandt,Burghard Klapp,Torsten Hoffmann,Hans-Ulrich Demuth
Publisher : Springer Science & Business Media
Release Date : 2003-03-31
Category : Medical
Total pages :359
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Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.

Alcohol in Health and Disease

Alcohol in Health and Disease
Author : Dharam Agarwal,Helmut K. Seitz
Publisher : CRC Press
Release Date : 2001-06-01
Category : Medical
Total pages :648
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This volume, based on presentations from the symposium on the health effects of alcohol held in Titisee, Germany, examines the physical and psychological consequences of alcohol use and abuse, and considers environmental and ethnic factors that lead to addiction and dependence. Discusses epidemiological studies that show the influence of light

Insulin-Like Growth Factors in Health and Disease, An Issue of Endocrinology and Metabolism Clinics - E-Book

Insulin-Like Growth Factors in Health and Disease, An Issue of Endocrinology and Metabolism Clinics - E-Book
Author : Claire M. Perks,Jeff M.P. Holly
Publisher : Elsevier Health Sciences
Release Date : 2012-07-03
Category : Medical
Total pages :960
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This issue of Endocrinology Clinics, authored by experts worldwide, provides essential updates about insulin-like growth factors (IGFs). The physiology is examined, including the latest in what we have learned from animal models as well as humans. The issue also covers IGFs and IGF system in the following: growth disorders; adipogenesis and obesity; muscle function and disease; bone; cancer; cardiac function and disease; normal and diseased kidney; peripheral nervous systems; gastrointestinal diseases; diabetes and metabolism; and IGF-1 central/degenerative diseases.

The Anatomy of the Central Nervous Organs in Health and Disease

The Anatomy of the Central Nervous Organs in Health and Disease
Author : Heinrich Obersteiner
Publisher : Unknown
Release Date : 1890
Category : Anatomy, Pathological
Total pages :432
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Microscopical Morphology of the Animal Body in Health and Disease

Microscopical Morphology of the Animal Body in Health and Disease
Author : Carl Heitzmann
Publisher : Unknown
Release Date : 1884
Category : Morphology
Total pages :849
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The Microscopic anatomy of the human body, in health and disease ... v.1

The Microscopic anatomy of the human body, in health and disease ... v.1
Author : Arthur Hill Hassall
Publisher : Unknown
Release Date : 1855
Category :
Total pages :129
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The Microscopic anatomy of the human body, in health and disease ... v.2

The Microscopic anatomy of the human body, in health and disease ... v.2
Author : Arthur Hill Hassall
Publisher : Unknown
Release Date : 1855
Category :
Total pages :129
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Tea in Health and Disease Prevention

Tea in Health and Disease Prevention
Author : Victor R. Preedy
Publisher : Academic Press
Release Date : 2013
Category : Cooking
Total pages :1573
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Examines the benefits of tea and its components, ranging from the anti-microbial to the anti-oxidant. Components such as catechins, theaflavins, polysaccharides, and others have been isolated and may have putative protective effects and modulate the biochemistry of a variety of cell types. 128 chapters explore improvements in the cardiovascular system, the brain, and other organs, and looks at possible applications in other disease areas --

Hepatobiliary Transport in Health and Disease

Hepatobiliary Transport in Health and Disease
Author : Dieter Häussinger,Verena Keitel,Ralf Kubitz
Publisher : Walter de Gruyter
Release Date : 2012-05-29
Category : Science
Total pages :312
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The transport systems involved in hepatobiliary transport have been cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. This book provides surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease. The book will be of interest for biochemists, structural chemists, biologists and clinicians.

Memory Mechanisms in Health and Disease

Memory Mechanisms in Health and Disease
Author : Karl Peter Giese
Publisher : World Scientific
Release Date : 2012
Category : Medical
Total pages :444
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Memory Mechanisms is an edited review volume that summarizes state-of-the-art knowledge on memory mechanisms at the molecular, cellular and circuit level. Each review is written by leading experts in the field, presenting not only current knowledge, but also discussing the concepts, providing critical reflections and suggesting an outlook for future studies. The memory mechanisms are also discussed in the context of diseases. Studies of memory deficits in disease models are introduced as well as approaches to restore memory deficits. Finally, the impact of contemporary memory research for psychiatry is illustrated.