June 13, 2021

Download Ebook Free Stellate Cells In Health And Disease

Stellate Cells in Health and Disease

Stellate Cells in Health and Disease
Author : Chandrashekhar Gandhi,Massimo Pinzani
Publisher : Academic Press
Release Date : 2015-04-10
Category : Science
Total pages :336
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Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.

Cooperation of Liver Cells in Health and Disease

Cooperation of Liver Cells in Health and Disease
Author : Z. Kmiec
Publisher : Springer Science & Business Media
Release Date : 2013-06-29
Category : Science
Total pages :151
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It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Role of Hepatic Stellate Cell-expressed Endosialin in Liver Health and Disease

Role of Hepatic Stellate Cell-expressed Endosialin in Liver Health and Disease
Author : Matthias Wieland
Publisher : Unknown
Release Date : 2013
Category :
Total pages :133
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Cooperation of Liver Cells in Health and Disease

Cooperation of Liver Cells in Health and Disease
Author : Z. Kmiec
Publisher : Springer Science & Business Media
Release Date : 2001-08-28
Category : Medical
Total pages :151
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It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Discoidin Domain Receptors in Health and Disease

Discoidin Domain Receptors in Health and Disease
Author : Rafael Fridman,Paul H. Huang
Publisher : Springer
Release Date : 2016-08-13
Category : Medical
Total pages :355
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The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.

Physiology in Health and Disease

Physiology in Health and Disease
Author : Carl John Wiggers
Publisher : Unknown
Release Date : 1937
Category : Human physiology
Total pages :1124
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Vitamin A in Health and Disease

Vitamin A in Health and Disease
Author : Rune Blomhoff
Publisher : CRC Press
Release Date : 1994-02-01
Category : Medical
Total pages :704
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This text details the metabolism of vitamin A and the mechanisms of action of vitamin A and the provitamin A carotenoids. It presents up-to-date information on the critical role vitamin A plays in vision, reproduction, foetal development, and the regulation and proliferation of cells. In addition, the book investigates evidence relating vitamin A intake to lung, breast, colon, rectal and prostate cancer.

Motor Control Mechanisms in Health and Disease

Motor Control Mechanisms in Health and Disease
Author : John E. Desmedt
Publisher : Unknown
Release Date : 1983
Category : Biological control systems
Total pages :1200
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Cytokines in Health and Disease

Cytokines in Health and Disease
Author : Steven L. Kunkel,Daniel G. Remick
Publisher : Marcel Dekker Incorporated
Release Date : 1992
Category : Medical
Total pages :568
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A comprehensive text providing much of the currently available knowledge in the field of cytokines. There are four areas covered, including general overviews of each of the major cytokines, listings of the important interactions these cytokines have with inflammatory cells, discussions of current an

The Warburg Effect Regulation Under Siege: The Intertwined Pathways in Health and Disease

The Warburg Effect Regulation Under Siege: The Intertwined Pathways in Health and Disease
Author : Concetta Bubici,Salvatore Papa
Publisher : Frontiers Media SA
Release Date : 2019-10-17
Category :
Total pages :129
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Many cells, including immune, neuronal, cancer and stem cells, become dependent on aerobic glycolysis to escape apoptosis and accommodate their bioenergetics needs. How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where it was first observed with the aim of decoding the molecular networks controlling its activation for therapeutic purposes. This Research Topic aimed to discuss and review all the intracellular signaling regulating the Warburg effect in cancerous and normal non-cancerous cells though original research articles, mini reviews and reviews.

The Human Gut-Liver-Axis in Health and Disease

The Human Gut-Liver-Axis in Health and Disease
Author : Aleksander Krag,Torben Hansen
Publisher : Springer
Release Date : 2018-11-09
Category : Medical
Total pages :294
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The book brings together the current knowledge and future perspectives of the complex physiology and pathophysiology of gut-liver interactions in health and disease. It provides readers with a unique overview and access to knowledge that cannot be obtained elsewhere. The structure is logical and covers all aspect including the normal physiology, changes in various liver diseases, technology, sample collection and various interventions. Thus suitable for general reading, lookup for specific questions or as a reference book within the area. The book allows the reader to access all the knowledge that has been generated within the last 10 years in this field.

Current Hepatology

Current Hepatology
Author : Gary Gitnick
Publisher : Year Book Medical Pub
Release Date : 1990-02
Category : Medical
Total pages :384
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Biochemistry and Cell Biology

Biochemistry and Cell Biology
Author : Anonim
Publisher : Unknown
Release Date : 2007
Category : Biochemistry
Total pages :129
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Special Cytology

Special Cytology
Author : Edmund Vincent Cowdry
Publisher : Unknown
Release Date : 1928
Category : Cells
Total pages :129
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Cytokine Effector Functions in Tissues

Cytokine Effector Functions in Tissues
Author : Maria Foti,Massimo Locati
Publisher : Academic Press
Release Date : 2017-07-17
Category : Medical
Total pages :304
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Cytokine Effector Functions in Tissues discusses the cytokines networks in the context of the specific-tissue environment. It is an up-to-date collection of articles that addresses the specific issue of how the cytokines are able to condition tissue specific homeostasis. The book helps the reader understand how cytokines network inside the tissues and highlights whether tissue-protection or exacerbation will be finally controlled. It describes the cytokines detected and regulated in different tissues, such as the brain, lungs, spleen, liver, pancreas and intestine, also addressing the issue of timing in specific cell types. Categorizes the cytokines based primarily on tissue and target cells Emphasizes different roles and outcomes observed during innate and adaptive response Represents a rapid guide to cytokines in health and disease in tissue and organ context Presents a different view on how known mediators may work if analyzed in a different perspective, determining the final outcome on tissue-specific target cells