June 15, 2021

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Stem Cells and Cell Therapy

Stem Cells and Cell Therapy
Author : Mohamed Al-Rubeai,Mariam Naciri
Publisher : Springer Science & Business Media
Release Date : 2013-10-01
Category : Medical
Total pages :189
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With the discovery of stem cells capable of multiplying indefinitely in culture and differentiating into many other cell types in appropriate conditions, new hopes were born in repair and replacement of damaged cells and tissues. The features of stem cells may provide treatment for some incurable diseases with some therapies are already in clinics, particularly those from adult stem cells. Some treatments will require large number of cells and may also require multiple doses, generating a growing demand for generating and processing large numbers of cells to meet the need of clinical applications. With this in mind, our aim is to provide a book on the subject of stem cells and cell therapy for researchers and students of cell biotechnology, bioengineering and bioproduction. This book is exceptional as it teaches researchers stem cells and cell therapy in that it covers the concepts and backgrounds necessary so that readers get a good understanding of the production of stem cells. The book covers three topics: The basics of stem cells and cell therapy, the use of stem cells for the treatment of human diseases, and stem cell processing. It includes chapters on neural and vascular stem vascular stem cell therapy, expansion engineering of embryonic stem cells, stem cell based production of blood cells and separation technologies for stem cells and cell therapy products. It is an informed and informative presentation of what modern research, science and engineering have learned about stem cells and their production and therapies. Addressing both the medical and production issues, this book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.

Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
Author : Lucas G. Chase,Mohan C Vemuri
Publisher : Springer Science & Business Media
Release Date : 2012-12-12
Category : Science
Total pages :456
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Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Stem Cell Therapy

Stem Cell Therapy
Author : Erik V. Greer
Publisher : Nova Publishers
Release Date : 2006
Category : Medical
Total pages :234
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Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, auto-immune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This new book brings together leading research from throughout the world in this frontier field.

Cardiovascular Regeneration and Stem Cell Therapy

Cardiovascular Regeneration and Stem Cell Therapy
Author : Annarosa Leri,Piero Anversa,William H. Frishman
Publisher : John Wiley & Sons
Release Date : 2008-04-15
Category : Medical
Total pages :248
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This book is the definitive reference on two of the most exciting areas of cardiovascular research – myocardial regeneration and stem cell therapy – for the treatment of disease. Edited by pioneers in the area, with contributions from every major investigator worldwide, it covers: The biology of stem cells The actions of stem cells from the bone marrow, the heart, and embryos on the normal restorative and repair functions of the heart and blood vessels How stem cells could contribute to myocardial recovery in the face of injury and aging How adjuvant therapy with growth factors might enhance stem cell activity in regeneration and repair Clinical applications and clinical experiences This fully referenced publication presents the current state of knowledge in both basic science and clinical practice, and is an essential reference for scientists, students, and clinicians.

Stem Cell Therapy for Vascular Diseases

Stem Cell Therapy for Vascular Diseases
Author : Tulio Pinho Navarro,Lara Lellis Navarro Minchillo Lopes,Alan Dardik
Publisher : Springer
Release Date : 2020-11-06
Category : Medical
Total pages :425
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Vascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers.

Stem Cell Therapy for Diabetes

Stem Cell Therapy for Diabetes
Author : Shimon Efrat
Publisher : Springer Science & Business Media
Release Date : 2009-12-01
Category : Medical
Total pages :291
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Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.

Stem Cell and Gene-Based Therapy

Stem Cell and Gene-Based Therapy
Author : Alexander Battler,Jonathan Leor
Publisher : Springer Science & Business Media
Release Date : 2005-12-23
Category : Medical
Total pages :422
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Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.

Regenerative Medicine and Stem Cell Therapy for the Eye

Regenerative Medicine and Stem Cell Therapy for the Eye
Author : Brian G. Ballios,Michael J. Young
Publisher : Springer
Release Date : 2019-02-18
Category : Science
Total pages :212
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This book provides an overview of the types, sources, and applications of stem cells in regenerating various ocular tissues, with a perspective on both potential applications of stem cells and possible challenges. The scope of the chapters include both preclinical and clinical applications, including stem cell-derived therapies based on endogenous tissue repair; stem cell transplantation and cell replacement therapy; gene therapy; and in vitro disease modelling. Additionally, the volume presents applications in both anterior and posterior ocular disease, with a particular focus on diseases of the ocular surface, cornea, limbus, and retina, including inherited retinal dystrophies as well as acquired diseases, such as age-related macular degeneration. Regenerative Medicine and Stem Cell Therapy for the Eye is an ideal book for advanced researchers in stem cell and ocular biology as well as clinical ophthalmologists, and will be of interest to readers with backgrounds in developmental biology and bioengineering. This book also Skillfully reviews cutting-edge advances in stem cell biology as applied to regenerative medicine and ocular disease Provides expert viewpoints on key hurdles and challenges to successful implementation of stem cell-derived therapies in the clinical domain Offers a multi-disciplinary, broad understanding of cell-based therapies for ocular diseases by incorporating perspectives from biomedical scientists, physicians, and engineers Examines the connection between cell therapy and gene editing, in particular relation to ocular disease

Stem Cell Therapy in Lysosomal Storage Diseases

Stem Cell Therapy in Lysosomal Storage Diseases
Author : Jaap Jan Boelens,Robert Wynn
Publisher : Springer Science & Business Media
Release Date : 2013-10-10
Category : Science
Total pages :171
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Stem Cell therapy for lysosomal diseases (LSDs) is developing rapidly. This volume discusses the history, current practice and future perspectives of stem cells in inborn errors of metabolism (IEM) and provides an international perspective on progress, limitations, and future directions (e.g. gene therapy, iPS, ES) in the field. Beginning with an overview of these diseases, the book covers the breadth of this topic from treatment options, bone marrow transplantation, and alternative treatment options, through long-term outcomes and future perspectives.

Biomaterials for Stem Cell Therapy

Biomaterials for Stem Cell Therapy
Author : Loredana De Bartolo,Augustinus Bader
Publisher : CRC Press
Release Date : 2013-01-28
Category : Science
Total pages :662
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Focused on stem cell applications, this book bridges the fields of biomaterials, offering new insights into constructing and regenerating tissues and organs. Its unique feature is linking diseases of the human body to current thinking on how to deal with them in the context of current concepts and technologies by means of an in-depth focus on biomaterials. The book assembles recent advances and covers a range of topics related to stem cell biology, biomaterials and technological approaches such as bioreactors written by top researchers in the field. Stem cells of both embryonic and adult origin are discussed with applications ranging, but not limited to, nerve regeneration, liver, pancreas, skin, trachea, cartilage and bone repair and cardiovascular therapy. Developments in the field reflecting the design and construction of the human body and its principal anatomy are discussed from a materials point of view. The book will be a valuable tool for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells. It will also be a source of reference for students in biotechnology, biomedical engineering, biology, biochemistry, materials sciences, pharmaceuticals, and veterinary and human medicine.

Stem Cell Revolution

Stem Cell Revolution
Author : Joseph Christiano
Publisher : Charisma Media
Release Date : 2018-01-16
Category : Health & Fitness
Total pages :240
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The Answer to Your Health Problems IS NOT WHAT YOU EXPECT What is adult stem cell therapy? Are there different adult stem cell treatment options? What type of conditions does adult stem cell therapy treat? What is the success rate? How much does it cost? Are there any risks or side effects? What's so great about adult stem cell therapy? Joseph "Dr. Joe" Christiano clears away the confusion surrounding this groundbreaking new treatment. Discover how stem cell activators target adult stem cells to reverse twenty-six conditions that may be adversely affecting your health. IT'S TIME TO JOIN THE REVOLUTION!

Stem Cells For Dummies

Stem Cells For Dummies
Author : Lawrence S.B. Goldstein,Meg Schneider
Publisher : John Wiley & Sons
Release Date : 2010-02-25
Category : Science
Total pages :364
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The first authoritative yet accessible guide to this controversial topic Stem Cell Research For Dummies offers a balanced, plain-English look at this politically charged topic, cutting away the hype and presenting the facts clearly for you, free from debate. It explains what stem cells are and what they do, the legalities of harvesting them and using them in research, the latest research findings from the U.S. and abroad, and the prospects for medical stem cell therapies in the short and long term. Explains the differences between adult stem cells and embryonic/umbilical cord stem cells Provides both sides of the political debate and the pros and cons of each side's opinions Includes medical success stories using stem cell therapy and its promise for the future Comprehensive and unbiased, Stem Cell Research For Dummies is the only guide you need to understand this volatile issue.

Advances in Stem Cell Therapy

Advances in Stem Cell Therapy
Author : Nagwa El-Badri
Publisher : Humana Press
Release Date : 2016-11-18
Category : Science
Total pages :310
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The book reviews the main approaches for generation of differentiated cells from various types of stem cells, including embryonic, placental and cord blood stem cells through marrow, adipose tissue and dental pulp. The book starts with an overview of experimental protocols applied to generate insulin secreting cells, neural cells, heart cells, and other tissue specific cells ex vivo and in experimental animals. This is followed by exhaustive review of clinical trials in these pathologies. It continues with a comparison of the merits of successful transplantation in humans versus animal experimentation, and highlights the most promising clinical applications in the field. Special chapters are devoted to the topic of tissue engineering and modern synthetic and biological scaffolds. It is essential reading for scientists and researchers in tissue engineering and stem cell research as well as clinicians who are involved in developing or testing stem cell therapies.

Stem Cell Therapy for Organ Failure

Stem Cell Therapy for Organ Failure
Author : Indumathi Somasundaram
Publisher : Springer
Release Date : 2015-01-02
Category : Medical
Total pages :278
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The book “STEM CELL THERAPY FOR ORGAN FAILURES” edited by Dr. S. Indumathi demonstrates the In Vitro and In vivo therapeutic strategies and applications of pre- and post-natal stem cells for treating the failures of various organ systems of our body in a wide perspective. It explores the past, present and the futuristic approach of the exciting field of stem cells and its intriguing properties involved in tissue repair and regeneration. The prime focus of this volume is to unravel the basic, advanced, therapeutic and translational approaches put-forth so far in the field of stem cells and regenerative medicine at research, pre-clinical and clinical levels. Stem cells has ushered in widespread interest and exciting possibilities for cell based therapies, albeit failures do prevail and small uncontrolled phase I/II studies are only signals generating, rather than definite proof of concept thereby limiting its applicability in curative therapeutics. Despite certain initiatives and meticulous untiring efforts, bringing this basic bench side research into advanced transitional bedside remained a challenge. Thus, this book embarked upon the expanding researches in these areas that seem decisive in improvising regenerative medical therapeutics, thereby leading to further path-breaking studies that cure all health challenges facing mankind. Overall, this book reveals the imperativeness of various stem cell sources and its utility in curative therapeutics.

The Future of Brain Repair - a Realist`s Guide to Stem Cell Therapy

The Future of Brain Repair - a Realist`s Guide to Stem Cell Therapy
Author : Jack Price
Publisher : Mit Press
Release Date : 2020
Category : Medical
Total pages :288
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"The Ultimate Therapy addresses the question: will stem cells bring about new, effective therapies for brain disorders? Stem cell therapies are the subject of enormous hype. The International Society for Stem Cell Research notes the 'near magical hold' that stem cell therapies have over patients' imaginations. This is not healthy. The intention with this book is to try to introduce some realism into this discussion. Certainly, stem cell therapies have real therapeutic promise, but it is important that patients, doctors, ethicists, regulators, and the public at large understand their potential and their limitations. Stem cell therapies have failed in the past. We need to understand why, and learn for the future. The therapies offered by unlicensed clinics are not the same as those going forward into proper regulated trials. We all need to understand the difference, and why it matters. Regenerative medicine for the brain-were it to emerge-would be the ultimate therapy. Brain diseases are more than just killers. Parkinson's disease, Alzheimer's disease, and stroke steal our capacity for thought, emotion, and social interaction. They destroy human faculties to a far greater degree even than disorders such as cancer. Further, repairing brain tissue is the ultimate biomedical challenge. The human brain is the most complex structure in the known universe, a structure we still barely understand. To be able to rebuild it once damaged is surely the ultimate prize for biomedical science. It is also the ultimate ethical challenge. We can rebuild joints, reconstitute blood, and regenerate liver with barely a thought for ethical concerns. But the prospect for brain repair stirs atavistic fears. Will I be the same person with new brain cells in my head? Stem cells offer the prospect for bringing this ultimate therapy to life, in a way that could be envisaged for no other therapeutic vehicle. Repairing brain with stem cells: truly the Ultimate Therapy"--