June 17, 2021

Download Ebook Free Studies On Hepatitis Viruses

Viral Hepatitis

Viral Hepatitis
Author : Howard C. Thomas,Anna S. F. Lok,Stephen A. Locarnini,Arie J. Zuckerman
Publisher : John Wiley & Sons
Release Date : 2013-07-22
Category : Medical
Total pages :624
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The 4th edition of Viral Hepatitis coverscomprehensively the entire complex field of infections caused byall of the different hepatitis viruses, which affect many millionsof people throughout the world with considerable morbidity andmortality. Howard Thomas and Arie Zuckerman are joined by Anna Lok from theUSA and Stephen Locarnini from Australia as Editors. Theyhave recruited leading researchers and physicians from manycountries, who have produced an authoritative account of currentknowledge and research on this important infection, including newinsights into immune response to HBV and HCV. The result is a comprehensive account on all aspects of viralhepatitis, including rapid advances in the diagnosis, management,treatment and prevention of a complex infection, which in the caseof hepatitis B, C and D may lead to severe complications includingchronic hepatitis, cirrhosis and hepatocellular carcinoma. The latest edition of Viral Hepatitis offers an essentialresource of current information for hepatologists,gastroenterologists, infectious diseases specialists and otherclinicians, researchers, public health physicians and National andInternational Health Authorities.

Research in Chronic Viral Hepatitis

Research in Chronic Viral Hepatitis
Author : W.H. Gerlich
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Medical
Total pages :304
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Chronic viral hepatitis remains one of the major medical problems worldwide. Neither a cure nor eradication of this disease is in sight. The chronic disease caused by hepatitis viruses type B, C and D is a much greater problem than the acute disease caused by the same viruses or by hepatitis viruses type A and E. Chronic viral hepatitis often remains unrecognized until the patient develops decompensated liver cirrhosis or hepatocellular carcinoma. Furthermore, unrecognized chronic virus carriers are a persistent source of infection by sexual and other close contacts as well as during many medical procedures. The viruses of chronic hepatitis are very different from each other from a taxonomical point of view, but they share many common pathogenic properties and they often coinfect individuals. Six years ago Carlo De Bac, Gloria Taliani (Rome) and I undertook an effort to bring together, under the auspices of the European Society against Virus Diseases, clinicians, laboratory physicians, epidemiologists, pathologists and molecular biologists whose primary research interest is chronic viral hepatitis. The contributions from these quite divergent participants to a meeting devoted solely to chronic viral hepatitis were most stimulating and valuable. As a result of the success of the first meeting in Fiuggi (Italy), a second followed in Siena (Italy) 1990 and the recent third meeting was held in Pisa (Italy). Most of the speakers expressed interest in publishing their contributions in the form of a proceedings volume, as was done in the case of the Siena meeting.

Studies of Hepatitis B Virus and Hepatitis C Virus Infection

Studies of Hepatitis B Virus and Hepatitis C Virus Infection
Author : Ming-Hsiang Sung
Publisher : Unknown
Release Date : 2002
Category :
Total pages :382
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Studies of Hepatitis B Virus and Hepatitis C Virus in SCID

Studies of Hepatitis B Virus and Hepatitis C Virus in SCID
Author : Ran Chen,University of Alberta. Department of Medical Microbiology and Immunology
Publisher : Unknown
Release Date : 2014
Category : Hepatitis B virus
Total pages :251
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Both hepatitis C virus (HCV) and hepatitis B virus (HBV) infections represent major global public health problems. Interferon (IFN) has been an important factor in both resolution of infection and in the treatment of both infections. Clinical data on anti-HBV and anti-HCV innate immune responses, in particular the IFN response, during natural infection in patients are limited. This is, in part, because most of patients are asymptomatic during acute stages of infection. IFN has been used to treat both HBV and HCV infections for years. Unfortunately, many patients do not respond to the IFN therapy. The reason for the variable treatment outcomes, in particular, the nonresponsiveness to IFN therapy in both HBV and HCV infections still remains unclear. In this thesis, IFN responses in HBV and HCV infections were studied using the severe combined immunodeficiency (SCID) / beige (bg) - albumin (Alb) / urokinase-type plasminogen activator (uPA) chimeric mouse model. The SCID/bg-Alb/uPA chimeric mouse model was initially reported in 2001. This model supports robust and sustained infection by clinical or tissue culture derived hepatitis viruses, such as hepatitis A virus (HAV), HBV and HCV. Evidence has shown that the antiviral response to IFN in the chimeric mouse often reflects closely the response of the identical virus in humans when treated with IFN. A time course of HCV infection was performed in SCID/bg-Alb/uPA chimeric mice to study an induced endogenous IFN response. There was a peak of interferon-stimulated gene (ISG) response at day-10 post infection, but no significant ISG upregulation was observed in long-term HCV infection in the mice. I also investigated the contributions of viral and host factors on the response of HCV infection to IFN treatment using two HCV viral strains differing in their IFN-sensitivity. These studies were performed in chimeric mice produced using three hepatocyte donors, each with distinct interleukin (IL) 28B single nucleotide polymorphisms (SNPs) at both rs12979860 and rs8099917 loci. My results showed that virus factors were the key factors determining the outcome of IFN therapy, whereas, viral interference with host janus kinase - signal transducer and activator of transcription (JAK-STAT) pathway as well as host factors, such as polymorphisms at the IL28B loci and pre-treatment levels of intrahepatic ISG expression, were less important in determining the outcome of IFN therapy in chimeric mice than they are in the patients. In addition, endogenous IFN response during the course of HBV in the SCID/bg- Alb/uPA chimeric mice was examined. No significant IFN or ISG response was detected in chimeric mice during the course of HBV infection. Since both the HBV and HCV viruses used in my studies were nonresponsive to exogenous IFN treatment in chimeric mice, the molecular mechanism of IFN nonresponsiveness of the two viruses was compared in a cohort of donor-matched chimeric mice. I found that in HBV infected chimeric mice, but not in mice infected with HCV, the JAK-STAT pathway was inhibited by STAT1 nucleus translocation blockage and thus expression downregulation of ISGs in response to exogenous IFN treatment. Finally, two collaborative projects were completed during my PhD. In the first study, the potential antiviral activity of exogenous HCV pathogen-associated molecular pattern (PAMP) RNA was investigated in HCV-infected SCID/bg- Alb/uPA chimeric mice. My results suggested that HCV PAMP RNA administration elicited an innate immune response in the livers of chimeric mice, which limited HCV infection. In the second study, we found that HCV infection in chimeric mice enhanced microRNA-27 expression and resulted in upregulating hepatic lipid droplet (LD) biogenesis. These results represented a novel mechanism by which HCV induces steatosis in chronic carriers of HCV.

Viral Hepatitis and Liver Disease

Viral Hepatitis and Liver Disease
Author : Kusuya Nishioka,Hiroshi Suzuki,Shunji Mishiro,Toshitsugu Oda
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Medical
Total pages :802
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A series of international symposia on viral hepatitis and liver disease has been held triannially, and called the "Olympics" of this research field. Our book presents the results of the eighth of these "Olympiads" which for the first time, was held in Asia (May 1993, Tokyo). Due to the rapid progress in research on both basic and clinical aspects of viral hepatitis and liver disease, the state of the art in this field is continually being updated, and our book provides a broad and in-depth survey of current work. The major topics in our book include molecular biology of the five known hepatitis viruses (HAV, HBV, HCV, HDV, and HEV), clinical implications of genetic variants of HBV and HCV, interferon treatment of HCV-related liver disease, and worldwide epidemiology and control of viral hepatitis. New subjects not seen in previous books, such as genotypes of HCV, are also covered. Expanding knowledge about the heterogeneity of the HCV genome has revealed a great variety of genotypes as well as their association with host pathogenesis and their varying responsiveness to interferon therapy. The first promising results of efforts to develop a hepatitis C vaccine are also presented. Finally, compared with its predecessors, our book contains many more papers from Asian countries, where the prevalence of viral hepatitis and liver disease is the highest in the world.

Hepatitis Viruses—Advances in Research and Application: 2012 Edition

Hepatitis Viruses—Advances in Research and Application: 2012 Edition
Author : Anonim
Publisher : ScholarlyEditions
Release Date : 2012-12-26
Category : Medical
Total pages :32
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Hepatitis Viruses—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Hepatitis Viruses in a compact format. The editors have built Hepatitis Viruses—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hepatitis Viruses in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hepatitis Viruses—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Hepatitis B Research Advances

Hepatitis B Research Advances
Author : Alicia P. Willis
Publisher : Nova Publishers
Release Date : 2007
Category : Medical
Total pages :313
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Hepatitis B is a disease of the liver caused by the Hepatitis B virus (HBV), a member of the Hepadnavirus family and one of several unrelated viral species which cause viral hepatitis. It was originally known as "serum hepatitis" and has caused current epidemics in parts of Asia and Africa. Hepatitis B is recognised as endemic in China and various other parts of Asia. The proportion of the world's population currently infected with the virus is 3 to 6%, but up to a third have been exposed. Symptoms of the acute illness caused by the virus include liver inflammation, vomiting, jaundice, and rarely, death. Chronic hepatitis B may cause liver cirrhosis which may then lead to liver cancer. This book presents the latest advances in the field.

Hepatitis Viruses of Man

Hepatitis Viruses of Man
Author : Arie J. Zuckerman,Colin R. Howard
Publisher : Academic Press
Release Date : 2014-06-28
Category : Health & Fitness
Total pages :278
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Hepatitis Viruses of Man covers the advances and developments in the study of viral hepatitis. The book discusses the history, epidemiology, and clinical features of viral hepatitis; the nomenclature and morphology of hepatitis viruses and their antigens; and the pathology of the liver in acute viral hepatitis. The text also describes the biochemical and biophysical properties of hepatitis B surface antigen; the nature and immunopathogenesis of hepatitis B; and the laboratory tests for hepatitis B surface antigen and antibody and hepatitis B core antigen and antibody. The carrier state; maternal transmission of hepatitis B and neonatal infection; and Hepatitis B virus and primary liver cancer are also considered. The book further tackles the laboratory tests for hepatitis A and the nature of the virus; immunization against hepatitis; and interferon and antiviral therapy in chronic hepatitis B infection. Microbiologists, pathologists, and medical doctors will find the book useful.

Studies on Hepatitis Viruses

Studies on Hepatitis Viruses
Author : Satya Prakash Gupta
Publisher : Academic Press
Release Date : 2018-06-20
Category : Medical
Total pages :242
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Studies on Hepatitis Viruses: Life Cycle, Structure, Functions, and Inhibition presents the latest on this systemic infection that predominantly affects the liver with inflammation that can be acute or chronic. Hepatitis viruses have been the subject of intense study in the last twenty years, with a wealth of information related to their lifecycle, structure, functions and inhibition being presented. This book compiles the most important developments and research, giving users a very useful guide on this evolving area of virology and medicinal chemistry. Provides comprehensive, state-of-the-art coverage of hepatitis virus infections, the virus' lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of viral hepatitis Presents an in-depth view of the structure and function of viral hepatitis Discusses classification, epidemiology, pathogenesis, natural history, clinical manifestations, diagnosis, complications, associated disorders and animal models

Hepatitis Viruses: Advances in Research and Treatment: 2011 Edition

Hepatitis Viruses: Advances in Research and Treatment: 2011 Edition
Author : Anonim
Publisher : ScholarlyEditions
Release Date : 2012-01-09
Category : Medical
Total pages :45
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Hepatitis Viruses: Advances in Research and Treatment: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Hepatitis Viruses in a concise format. The editors have built Hepatitis Viruses: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hepatitis Viruses in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hepatitis Viruses: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Hepatitis C Virus

Hepatitis C Virus
Author : Alvaro Perez Gonzales,Angel Alonso Verracruz
Publisher : Nova Biomedical
Release Date : 2012
Category : Medical
Total pages :132
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Chronic Hepatitis C virus (HCV) infection is a serious condition affecting over 180 million people world-wide. The virus infects the liver and while it is estimated that 20 per cent of those infected clear the virus spontaneously, the virus persists in the majority of individuals leading to liver fibrosis, cirrhosis, and hepatocellular carcinoma. This book presents topical research in the study of the epidemiology, pathogenesis and treatment of Hepatitic C Virus including: genome-wide association studies regarding HCV infection; hepatic and blood dendritic cell subsets in patients with chronic HCV; bone metabolism disorders in HCV infection; Socs1 involvement in liver damage during HCV infection; asymptomatic low-level HCV persistence; and HCV infection as the leading cause of liver disease in renal transplant recipients.

Case Studies in Infectious Disease: Hepatitis B Virus

Case Studies in Infectious Disease: Hepatitis B Virus
Author : Peter Lydyard,Michael Cole,John Holton,Will Irving,Nino Porakishvili,Pradhib Venkatesan,Kate Ward
Publisher : Garland Science
Release Date : 2009-12
Category : Medical
Total pages :608
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Case Studies in Infectious Disease: Hepatitis B virus presents the natural history of this infection from point of entry of the pathogen through pathogenesis, clinical presentation, diagnosis, and treatment. A set of core questions explores the nature, causation, host response, manifestations, and management of this infectious process. This case also includes summary bullet points, questions and answers, and references.

Viral Hepatitis Molecular Biology Diagnosis and Control

Viral Hepatitis Molecular Biology Diagnosis and Control
Author : Isa K. Mushahwar
Publisher : Gulf Professional Publishing
Release Date : 2004
Category : Medical
Total pages :264
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Provides an overview of the latest developments and research studies in viral hepatitis. Covers the history of these viruses, their molecular biology, diagnosis, epidemiology, and control. Abundant halftone illustrations.

Immunopathologic Studies of Hepatitis B Virus Infection in Humans

Immunopathologic Studies of Hepatitis B Virus Infection in Humans
Author : Paul David Swenson
Publisher : Unknown
Release Date : 1979
Category :
Total pages :266
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Hepatitis Viruses

Hepatitis Viruses
Author : Jing-Hsiung James Ou
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Science
Total pages :281
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Hepatitis viruses research started more than fifty years ago. The names of hepatitis A and hepatitis B were introduced in 1947 when it became clear that there were two types of hepatitis that were transmitted either enterically or parenterally. It became apparent in the 1970's that there were additional hepatitis viruses distinct from hepatitis A and hepatitis B, and thus, the term non-A, non-B hepatitis was introduced. The non-A, non-B hepatitis was further divided into post-transfusion non-A, non-B hepatitis and enterically-transmitted non-A, non-B hepatitis in the 1980's. By the end of the 1980's, both post-transfusion non-A, non-B virus and enterically-transmitted non-A, non-B virus had been identified and renamed hepatitis C virus and hepatitis E virus, respectively. Hepatitis delta antigen was first recognized as an antigen associated with hepatitis B virus infection in the 1970's. In the early 1980's, a virus was isolated and named hepatitis delta virus. These five different hepatitis viruses have distinct replication pathways and are major health concerns. They have become an important topic for teaching to graduate-level and medical students. Hepatitis Viruses provides a comprehensive, up-to-date review of these viruses to readers. Each chapter is written by one of the top researchers in the field, and topics include: the epidemiology and the natural history of infection of these viruses, the molecular biology and the replication cycle of individual hepatitis viruses, host-virus interactions and the pathogenesis of hepatitis viruses, the immunology of hepatitis viruses, the relationship between hepatitis viruses and hepatocellular carcinoma, the viral vaccines and antiviral drugs. This book can serve as a supplemental reading material to graduate students and medical students, and to any researcher who would like to learn more about hepatitis viruses.