November 30, 2020

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Tendon Regeneration

Tendon Regeneration
Author : Manuela E Gomes,Rui L Reis,Márcia T Rodrigues
Publisher : Academic Press
Release Date : 2015-08-08
Category : Technology & Engineering
Total pages :470
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Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes is the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies. Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective fields present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field. Provides an overview of tendon biology, disease, and tissue engineering approaches Presents modern, alternative approaches to developing functional tissue solutions discussed Includes valuable information for those interested in tissue engineering, tissue regeneration, tissue physiology, and regenerative medicine Explores physiology, pathology, and surgical reconstruction, building a natural progression that enhances tendon regeneration practices Covers recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field

Repair and Regeneration of Ligaments, Tendons, and Joint Capsule

Repair and Regeneration of Ligaments, Tendons, and Joint Capsule
Author : William R. Walsh
Publisher : Springer Science & Business Media
Release Date : 2007-10-28
Category : Medical
Total pages :324
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A comprehensive and authoritative review of the most important scientific and clinically relevant topics today in ligaments, tendons, and capsular biology, including their biomechanics and surgical reconstruction. The authors review the basic science of tendons in the hand and shoulder ligaments, the current clinical status of the shoulder and cruciate ligaments, and the latest advances in research on the healing of ligament and tendon to bone, artificial ligaments, and gene therapy. They also cover the major type 1 collagen soft tissues that are of particular interest to upper extremity surgeons and sports medicine specialists.

In Vitro Characteristics of Porcine Tendon Hydrogel for Tendon Regeneration

In Vitro Characteristics of Porcine Tendon Hydrogel for Tendon Regeneration
Author : Anonim
Publisher : Unknown
Release Date : 2016
Category :
Total pages :129
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Abstract : Purpose: Previous work has characterized the development of a human tendon hydrogel capable of improving mechanical strength after tendon injury. Animal tendon hydrogel has not yet been described, but would prove beneficial due to the cost and ethical concerns associated with the use of human cadaveric tendon. This study details the manufacture and assesses the biocompatibility of porcine tendon hydrogel seeded with human adipoderived stem cells (ASCs). Materials and Methods: Porcine tendon was dissected from surrounding connective and muscle tissue and decellularized via 0.2% sodium dodecyl sulfate and 0.2% sodium dodecyl sulfate/ethylenediaminetetraacetic acid wash solutions before lyophilization. Tendon was milled and reconstituted by previously described methods. Decellularization was confirmed by hematoxylin-eosin staining, SYTO Green 11 nucleic acid dye, and DNeasy assay. The protein composition of milled tendon matrix before and after digestion was identified by mass spectrometry. Rheological properties were determined using an ARG2 rheometer. Biocompatibility was assessed by live/dead assay. The proliferation of human ASCs seeded in porcine and human hydrogel was measured by MTS assay. All experimental conditions were performed in triplicate. Results: Decellularization of porcine tendon was successful. Mass spectrometry showed that collagen composes one third of milled porcine tendon before and after pepsin digestion. Rheology demonstrated that porcine hydrogel maintains a fluid consistency over a range of temperatures, unlike human hydrogel, which tends to solidify. Live/dead staining revealed that human ASCs survive in hydrogel 7 days after seeding and retain spindle-like morphology. MTS assay at day 3 and day 5 showed that human ASC proliferation was marginally greater in human hydrogel. Conclusions: After reconstitution and digestion, porcine hydrogel was capable of supporting growth of human ASCs. The minimal difference in proliferative capacity suggests that porcine tendon hydrogel may be an effective and viable alternative to human hydrogel for the enhancement of tendon healing.

Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms

Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration Mechanisms
Author : Luciano Merlini,Cesare Faldini,Paolo Bonaldo
Publisher : Frontiers Media SA
Release Date : 2017-02-24
Category :
Total pages :129
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Aging is characterized by progressive deterioration of walking ability. This function loss has multiple causes including central and peripheral nerve dysfunction, loss of muscle mass and strength, as well as joints and bone alterations. Muscle-tendon unit and its innervation has a pivotal role in motor function performance that can be disrupted by overuse degeneration and aging. Research has shown that overuse degeneration and aging also share some pathophysiological mechanisms including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and modification of signalling and stress response pathways. This Research Topic is intended to bring together basic researchers and clinicians working in the area of neuroscience, aging, sarcopenia and orthopaedics in human and in animal models. The aim of this cross-fertilization is to accelerate our understanding of the mechanisms involved in aging and degeneration of the muscle-tendon unit and its innervation and to explore the therapeutic potential of pharmacological and physical therapy interventions.

3D Electrospun Bundles of Polycaprolactone for Tendon Regeneration

3D Electrospun Bundles of Polycaprolactone for Tendon Regeneration
Author : Lucy Bosworth
Publisher : Unknown
Release Date : 2009
Category :
Total pages :129
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Nanoengineering in Musculoskeletal Regeneration

Nanoengineering in Musculoskeletal Regeneration
Author : Mehdi Razavi
Publisher : Academic Press
Release Date : 2020-08
Category : Science
Total pages :129
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Regenerative medicine focuses on using stem cell biology to advance medical therapies for devastating disorders. Musculoskeletal degeneration and complications from injuries have become more prevalent as people live longer and increasingly participate in rigorous athletic and recreational activities. Additionally, defects in skeletal tissues may immobilize people and cause inflammation and pain. Musculoskeletal regeneration research provides solutions to repair, restore or replace skeletal elements and associated tissues that are affected by acute injury, chronic degeneration, genetic dysfunction and cancer-related defects. The goal of musculoskeletal regeneration medicine research is to improve quality of life and outcomes for people with musculoskeletal injury or degradation. Nanoengineering in Musculoskeletal Regeneration provides the reader an updated summary of therapeutic pipeline from biomedical discovery to clinical implementation, improving treatments for patients with conditions of the muscles, tendons, cartilage, meniscus and bone. This text presents novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in the musculoskeletal regeneration. Content includes basic, translational, and clinical research addressing musculoskeletal repair and regeneration for the treatment of diseases and injuries of the skeleton and its associated tissues.

The Achilles Tendon

The Achilles Tendon
Author : James A. Nunley
Publisher : Springer Science & Business Media
Release Date : 2008-12-10
Category : Medical
Total pages :256
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Disorders of the Achilles tendon are universal, affecting people in a wide range of age groups. Because the Achilles tendon is one of the most pow- ful musculotendinous structures in the body, the impact of an injury to the Achilles tendon becomes magnified. There is a wide range of disorders or problems that can involve the insertional region, where pathology may rest with bone, tendon, or bursae. A completely different set of pathologic entities resides in the noninsertional region, one of which may include the frustrating degenerative tendinopathy. As our growing population ages but remains phy- cally active longer into life, the incidence of these disorders will continue to increase. I am proud to be given the opportunity to write the foreword to this text, which is intended for foot and ankle surgeons worldwide. Seldom does a book on a single entity become a current concepts review, as this work has. Too often, textbooks are not published for several years after the chapters have been written, making them obsolete upon publication. Not so with this book, which deals with timely topics on the Achilles tendon. Dr. James Nunley has compiled this work in slightly over a year, thus providing the reader with sta- of-the-art material. Dr. Nunley had the foresight to create a much needed techniques-oriented book dealing with the complexities of the Achilles tendon. His approach was to develop a comprehensive guide to managing Achilles tendon problems.

Tissue Engineering and Regenerative Medicine

Tissue Engineering and Regenerative Medicine
Author : Phuc Van Pham
Publisher : Springer
Release Date : 2019-10-08
Category : Science
Total pages :225
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This new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Tissue Engineering and Regenerative Medicine is a proceedings volume which reflects papers presented at the 3rd bi-annual Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Stem Cells: Biology and Engineering it provides a complete overview of the papers from that meeting of international experts.

Muscle and Tendon Injuries

Muscle and Tendon Injuries
Author : Gian Luigi Canata,Pieter d'Hooghe,Kenneth J. Hunt
Publisher : Springer
Release Date : 2017-05-10
Category : Medical
Total pages :450
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This book explores in a comprehensive manner the causes and symptoms of muscle and tendon pathologies, the available diagnostic procedures, and current treatment approaches. Specific aspects of the anatomy, biomechanics, and function of muscles and tendons are analyzed, and detailed guidance is provided on the most innovative methods – both conservative and surgical – for ensuring that the athlete can make a safe and quick return to sporting activity. Optimal care of tendon and muscle injuries in sportspeople requires effective cooperation of sports scientists and medical practitioners to identify the best ways of preserving muscle and tendon structures and to develop new strategies for their rehabilitation and regeneration. Muscle and Tendon Injuries is an excellent multidisciplinary reference written by the leading experts in the field and published in collaboration with ISAKOS. It will appeal to all specialists in sports medicine and sports traumatology who are seeking a state of the art update on the management of muscle and tendon disorders.

The Anterior Cruciate Ligament: Reconstruction and Basic Science E-Book

The Anterior Cruciate Ligament: Reconstruction and Basic Science E-Book
Author : Chadwick Prodromos,Charles Brown,Freddie H. Fu,Anastasios D. Georgoulis,Alberto Gobbi,Stephen M. Howell,Don Johnson,Lonnie E. Paulos,K. Donald Shelbourne
Publisher : Elsevier Health Sciences
Release Date : 2007-12-27
Category : Medical
Total pages :672
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Master the very latest clinical and technical information on the full range of anterior cruciate ligament reconstruction techniques. Both inside the remarkably user-friendly printed version of this Expert Consult title and on its fully searchable web site, you'll find detailed coverage of hamstring, allograft and bone-tendon-bone (BTB) ACL reconstruction (including single versus double bundle techniques), and hamstring graft harvesting; plus fixation devices, rehabilitation, revision ACLR surgery, and much more! A "dream team" of ACL surgeons provides the advanced guidance you need to overcome the toughest challenges in this area. A comparison of the full range of graft options for ACL reconstruction makes it easier to choose the best approach for each patient. State-of-the-art information on the latest principles and technical considerations helps you avoid complications. ‘How to' principles of post-op rehabilitation and revision ACL surgery optimize patient outcome. Access to the full contents of the book online enables you to consult it from any computer and perform rapid searches. Also available in an upgradeable premium online version including fully searchable text PLUS timely updates.

Biomechanics of Tendons and Ligaments

Biomechanics of Tendons and Ligaments
Author : Johanna Buschmann,Gabriella Meier Bürgisser
Publisher : Woodhead Publishing
Release Date : 2017-05-10
Category : Technology & Engineering
Total pages :350
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Biomechanics of Tendons and Ligaments: Tissue Reconstruction looks at the structure and function of tendons and ligaments. Biological and synthetic biomaterials for their reconstruction and regeneration are reviewed, and their biomechanical performance is discussed. Regeneration tendons and ligaments are soft connective tissues which are essential for the biomechanical function of the skeletal system. These tissues are often prone to injuries which can range from repetition and overuse, to tears and ruptures. Understanding the biomechanical properties of ligaments and tendons is essential for their repair and regeneration. Contains systematic coverage on how both healthy and injured tendons and ligaments work Includes coverage of repair and regeneration strategies for tendons and ligaments Presents an Interdisciplinary analysis on the topic

Regenerative Medicine and Plastic Surgery

Regenerative Medicine and Plastic Surgery
Author : Dominik Duscher,Melvin A. Shiffman
Publisher : Springer Nature
Release Date : 2019-11-27
Category : Science
Total pages :472
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This book presents the latest advances in the field of regenerative medicine in plastic surgery. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner.The first part introduces readers to essential principles of skin and soft tissue regeneration, e.g. the possibility of using mesenchymal stem cells for wound healing. Since bone serves as a supportive tissue in most of the body, bone regeneration is an important aspect of regenerative medicine; accordingly, the second part discusses the novel bone implants, activated bone grafts and bone tissue engineering. The book’s third part, focusing on cartilage regeneration, includes chapters on e.g. stem cells and ear regeneration. In turn, part four addresses muscle and tendon regeneration: from tendon to bone and tendon to muscle, as well as aging in the realm of muscle regeneration. Lastly, part five highlights nerve regeneration, deepening surgeons’ knowledge to help them successfully treat injuries to the peripheral neural system. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "With beautiful clinical images and artwork, this book will be a central companion to both practicing plastic surgeons who wish to remain abreast of oncoming technologic advances and regenerative medicine researchers who wish to understand the current state of the art of surgical reconstruction." - Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine

Transforming Growth Factors—Advances in Research and Application: 2012 Edition

Transforming Growth Factors—Advances in Research and Application: 2012 Edition
Author : Anonim
Publisher : ScholarlyEditions
Release Date : 2012-12-26
Category : Science
Total pages :231
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Transforming Growth Factors—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Transforming Growth Factors. The editors have built Transforming Growth Factors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Transforming Growth Factors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Transforming Growth Factors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Surgical Techniques of the Shoulder, Elbow and Knee in Sports Medicine E-Book

Surgical Techniques of the Shoulder, Elbow and Knee in Sports Medicine E-Book
Author : Brian J. Cole,Jon K. Sekiya
Publisher : Elsevier Health Sciences
Release Date : 2013-06-05
Category : Medical
Total pages :1016
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Surgical Techniques of the Shoulder, Elbow, and Knee in Sports Medicine presents you with a step-by-step approach on performing both open and arthroscopic surgeries for sports-related injuries. This medical reference book offers all of the expert guidance you need on everything from patient positioning and the latest orthopaedic surgery techniques, through pearls and pitfalls and post-operative care. An international group of contributors equips you with a worldwide perspective on the most recent orthopaedic advances, making Surgical Techniques of the Shoulder, Elbow, and Knee in Sports Medicine your go-to digest of today's common procedures. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Ensure optimal outcomes from each shoulder, elbow and knee procedure with this orthopaedic surgery text's consistent, step-by-step approach, coupled with numerous tips, pearls, pitfalls, and images gleaned from surgeons specializing in sports injuries. Apply the latest open and arthroscopic techniques, including arthroscopic rotator cuff repair and hamstring and allograft ACL reconstruction. Access the full text and expanded surgical video collection online at Expert Consult. Broaden your knowledge base with contributions from rising international orthopaedic and sports medicine authorities, who offer a global perspective on today's most common techniques including rotator cuff procedures, shoulder and knee instability, and athletic throwing arm issues. Confidently interpret state-of-the-art diagnostic studies with help from a brand-new chapter on sports medicine imaging for each treated joint. See for yourself how key techniques are performed with an expanded online surgical video collection covering Arthroscopic Rotator Cuff Repair: Double Row Techniques; Arthroscopic Repair of Multidirectional Instability of the Shoulder; Ulnar Collateral Ligament Repair and Reconstruction: DANE Technique; Double Bundle Anterior Cruciate Ligament Reconstruction; and Management of Proximal Tibiofibular Instability.

A Treatise on Surgery by American Authors

A Treatise on Surgery by American Authors
Author : Roswell Park
Publisher : Unknown
Release Date : 1896
Category : Surgery
Total pages :804
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