March 3, 2021

Download Ebook Free The Common Marmoset In Captivity And Biomedical Research

The Common Marmoset in Captivity and Biomedical Research

The Common Marmoset in Captivity and Biomedical Research
Author : Robert P. Marini,Lynn M. Wachtman,Suzette D. Tardif,Keith Mansfield,James G. Fox
Publisher : Academic Press
Release Date : 2018-11-19
Category : Science
Total pages :570
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The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset (Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such as macaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate model to study a number of poorly understood disorders, like autism. Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications Includes contributions from renowned and international authors and editors Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series

Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research

Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research
Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Roundtable on Science and Welfare in Laboratory Animal Use
Publisher : National Academies Press
Release Date : 2019-08-26
Category : Science
Total pages :122
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The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.

Reproduction in New World Primates

Reproduction in New World Primates
Author : J.P. Hearn
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Medical
Total pages :224
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The New World primates are becoming widely used in scientific and medical work in fields from anthropology to zoology, behaviour to urology. They have unique attributes for studies in cancer, infectious diseases, genetics, virology and reproduction. However, it is only now that their reproductive physiology is being clarified in any depth and this book is a first synthesis of that knowledge. The nine authors involved in this project have presented an up to date account of the major New World species used in biological and medical science. In addition to their distribution and conservation in the wild, essential biological data from laboratory studies are presented on reproductive cycles, gestation length, seasonal breeding, puberty and other factors. The major applications of these species in research are explored. Whenever possible, research workers should steer away from using endangered species in their studies. The New World monkeys used in research in any numbers are still fairly common ~n the wild, yet their greatest advantages are ~n their smalle size and high fecundity. This makes possible the establishment of self sustaining captive breeding colonies at a fraction of the time and cost necessary for the more conventional Old World laboratory primates. Consequently the drain on wild stocks need not be extensive as only breeding nuclei should be necessary.

Genome Editing in Neurosciences

Genome Editing in Neurosciences
Author : Rudolf Jaenisch,Feng Zhang,Fred Gage
Publisher : Springer
Release Date : 2017-09-14
Category : Medical
Total pages :123
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This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

The Zebrafish in Biomedical Research

The Zebrafish in Biomedical Research
Author : Samuel Cartner,Judith S. Eisen,Susan F. Farmer,Karen J. Guillemin,Michael L. Kent,George E. Sanders
Publisher : Academic Press
Release Date : 2019-11-22
Category : Science
Total pages :718
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The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series

The Smallest Anthropoids

The Smallest Anthropoids
Author : Susan M. Ford,Leila M. Porter,Lesa C. Davis
Publisher : Springer Science & Business Media
Release Date : 2009-08-29
Category : Science
Total pages :508
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Here is a comprehensive examination of the newly recognized callimico/marmoset clade, which includes the smallest anthropoid primates on earth. It features sections on phylogeny, taxonomy and functional anatomy, behavioral ecology, and reproductive physiology.

Laboratory Animal Medicine

Laboratory Animal Medicine
Author : Margi Sirois
Publisher : Mosby
Release Date : 2005
Category : Medical
Total pages :350
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This combination text and lab manual provides clinically relevant coverage of laboratory animal medicine and procedures. It covers a variety of species, including rats, mice, guinea pigs, hamsters, rabbits, gerbils, ferrets, nonhuman primates, and in a separate chapter, nontraditional lab animals, such as swine, chinchillas, armadillos, reptiles, amphibians, bats, farm animals, and dogs and cats. Coverage of each species is presented in a consistent format that includes taxonomy, anatomy and physiology, uses in biomedical research, reproduction, behavior, husbandry, restraint and handling, identification methods, injection techniques, medication administration and anesthesia, blood collection, common diseases, and euthanasia. Other key topics include the laboratory setting, regulatory guidelines, and ethical considerations. The lab manual portion of the book features a variety of exercises and observation sheets. Comprehensive coverage of a variety of topics such as animal species, the laboratory setting, regulatory guidelines, and ethical considerations prepares readers for a career in laboratory animal medicine Familiarizes readers with the handling, behavior, nutrition, and lab and treatment procedures for a large variety of common and nontraditional laboratory animals The consistent organization of each species chapter makes it easy for readers to quickly identify similarities and differences among various laboratory animals Laboratory exercises are included in a perforated section at the end of the book, allowing users to apply their knowledge and develop job skills Features a wealth of user-friendly features such as a two-color design, learning objectives, key points, and review questions Provides detailed information on specific legal and ethical requirements of lab animal care and use, including the ethics of pain management Convenient boxes and tables provide quick access to important anatomic and physiologic data for each species Discusses specific uses of each species in biomedical research, providing readers with a perspective on animal use that allows them to explain the benefits of animal use as required by veterinary technology program accreditation procedures

Nonhuman Primates in Biomedical Research

Nonhuman Primates in Biomedical Research
Author : Anonim
Publisher : Academic Press
Release Date : 1995-08-04
Category : Medical
Total pages :428
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This book represents the most comprehensive publication of its type on nonhuman primates. It also provides basic information on the biology and management of primates for anyone responsible for the care and use of these animals. A related book on primate diseases will be published in 1996. Stresses the following major topics: Biology and medical management Reproductive physiology and breeding Nutrition Biohazards

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
Author : Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer
Publisher : Academic Press
Release Date : 2015-03-13
Category : Medical
Total pages :716
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The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes

Animal-centric Care and Management

Animal-centric Care and Management
Author : Dorte Bratbo Sørensen,Sylvie Cloutier,Brianna N. Gaskill
Publisher : CRC Press
Release Date : 2020-10-14
Category : Medical
Total pages :190
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The concept of the 3Rs (Refinement, Reduction and Replacement) has been used as a framework for improving the welfare of laboratory animals for the last half century. By establishing an animal-centric view on housing and management, Animal-centric Care and Management: Enhancing Refinement in Biomedical Research takes Russell and Burch’s definition of Refinement as "elimination of inhumanities" and goes further. Rather than fitting animals into experimental conditions, it encourages readers to adjust conditions to better meet the behavioral, emotional, physical, and physiological needs and preferences of the animals. The team of expert authors, from the fields of laboratory animal science, ethology, biology as well as animal training, provide ideas for creating housing conditions and handling procedures that induce, to the best of current abilities and knowledge, a long-term positive state of mind in the animals under our care. This book is written for animal caretakers, animal health technicians, researchers, animal facility managers, laboratory animal veterinarians, and anyone who engages in work with living experimental animals or is interested in the continuous improvement of laboratory animal welfare. This interdisciplinary guide will act as a catalyst, resulting in multiple viewpoints and fields collaborating to optimize laboratory animal welfare.

Biosafety in Microbiological and Biomedical Laboratories

Biosafety in Microbiological and Biomedical Laboratories
Author : L. Casey Chosewood
Publisher : DIANE Publishing
Release Date : 2007-08
Category :
Total pages :421
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¿Biosafety in Microbiological & Biomedical Labs.¿ quickly became the cornerstone of biosafety practice & policy upon first pub. in 1984. The info. is advisory in nature even though legislation & reg¿n., in some circumstances, have overtaken it & made compliance with the guidance mandatory. This rev. contains these add¿l. chap.: Occupat¿l. med. & immunization; Decontam. & sterilization; Lab. biosecurity & risk assess.; Biosafety Level 3 (Ag.) labs.; Agent summary state. for some ag. pathogens; & Biological toxins. Also, chapters on the principles & practices of biosafety & on risk assess. were expanded; all agent summary state. & append. were rev.; & efforts were made to harmonize recommend. with reg¿s. promulgated by other fed. agencies.

The Laboratory Primate

The Laboratory Primate
Author : Anonim
Publisher : Elsevier
Release Date : 2005-09-19
Category : Science
Total pages :650
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A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models cover the major areas of biomedical research, including AIDS, cancer, neurobiology and gene therapy. Assisted reproductive technology, tissue typing, and minimum group sizes for infectious disease/vaccine studies are also included. Two-color, user-friendly format, with copious illustrations and color plates Includes detailed, well-illustrated sections on gross & microscopic anatomy, common diseases, and special procedures, including surgical techniques

Living New World Monkeys (Platyrrhini), Volume 1

Living New World Monkeys (Platyrrhini), Volume 1
Author : Philip Hershkovitz
Publisher : University of Chicago Press
Release Date : 1977-12-01
Category : Nature
Total pages :1132
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In this long-awaited work, Philip Hershkovitz provides the most thorough and comprehensive treatise ever published on New World monkeys. The volume gives a detailed account of the origin, evolution, dispersal, and behavior of platyrrhines and a systematic arrangement of all known forms, living and extinct. During an eleven-year period, Hershkovitz examined more than 3,100 museum-preserved specimens and relevant primate fossils and observed hundreds of animals in captivity and thousands in the wild state. He presents his results in an elegant and encyclopedic text, lavishly illustrated with 520 figures and 7 color plates. Hershkovitz opens the study with a brief history and a definition, characterization, and comparison of primates as a taxonomic unit. Basing his work on nearly all known genera of living primates, the author deals with New World monkeys from comparative anatomical and evolutionary points of view. He examines display characters, pelage, the evolution of color patterns, primate locomotion, cranial and dental morphology, and the central nervous system. The final and most extensive part of the volume is devoted to the taxonomy and biology of the family Callitrichidae, comprising marmosets and tamarins, and the family Callimiconidae, represented by the callimico alone. Hershkovitz concludes with an exhaustive bibliography of more than 2,500 published works and a gazetteer of essential geographic data.

Ethics Dumping

Ethics Dumping
Author : Doris Schroeder,Julie Cook,François Hirsch,Solveig Fenet,Vasantha Muthuswamy
Publisher : Springer
Release Date : 2017-12-04
Category : Philosophy
Total pages :134
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This open access book provides original, up-to-date case studies of “ethics dumping” that were largely facilitated by loopholes in the ethics governance of low and middle-income countries. It is instructive even to experienced researchers since it provides a voice to vulnerable populations from the fore mentioned countries. Ensuring the ethical conduct of North-South collaborations in research is a process fraught with difficulties. The background conditions under which such collaborations take place include extreme differentials in available income and power, as well as a past history of colonialism, while differences in culture can add a new layer of complications. In this context, up-to-date case studies of unethical conduct are essential for research ethics training.

Guidelines for the Humane Transportation of Research Animals

Guidelines for the Humane Transportation of Research Animals
Author : National Research Council,Division on Earth and Life Studies,Institute for Laboratory Animal Research,Committee on Guidelines for the Humane Transportation of Laboratory Animals
Publisher : National Academies Press
Release Date : 2006-08-14
Category : Science
Total pages :164
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Arranging the transportation of animals at research facilities is often an ordeal. There is a confusing patchwork of local, national, and international regulations; a perceived lack of high-quality shipping services; a dearth of science-based good practices; and a lack of biosafety standards. It's a challenge â€"and an impediment to biomedical research. Guidelines for the Humane Transportation of Research Animals identifies the current problems encountered in the transportation of research animals and offers recommendations aimed at local and federal officials to rectify these problems. This book also includes a set of good practices based on the extensive body of literature on transportation of agricultural animals, universal concepts of physiology, and a scientific understanding of species-specific needs and differences. Good practices were developed by the committee to address thermal environment, space requirements, food and water requirements, social interaction, monitoring of transportation, emergency procedures, personnel training, and biosecurity. Guidelines for the Humane Transportation of Research Animals is an essential guide for all researchers, animal care technicians, facilities managers, administrators, and animal care and use committees at research institutions.