November 29, 2020

Download Ebook Free The Comprehensive Sourcebook Of Bacterial Protein Toxins

The Comprehensive Sourcebook of Bacterial Protein Toxins

The Comprehensive Sourcebook of Bacterial Protein Toxins
Author : Joseph E. Alouf,Daniel Ladant,Michel R. Popoff
Publisher : Elsevier
Release Date : 2005-12-20
Category : Science
Total pages :1072
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This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology Includes the major toxins of both basic and clinical interest are described in depth Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology Evolutionary and functional aspects of bacterial toxins evaluated and summarized Toxin applications in cell biology presented Therapy (cancer therapy, dystonias) discussed Vaccines (native and genetically engineered vaccines) featured Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

The Comprehensive Sourcebook of Bacterial Protein Toxins

The Comprehensive Sourcebook of Bacterial Protein Toxins
Author : Joseph E. Alouf,Daniel Ladant,Michel R. Popoff
Publisher : Academic Press
Release Date : 2015-05-29
Category : Science
Total pages :1200
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The Comprehensive Sourcebook of Bacterial Protein Toxins 4th Edition, contains chapters written by internationally known and well-respected specialists. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins. Bacterial toxins are involved in the pathogenesis of many bacteria, some of which are responsible for severe diseases in human and animals, but can also be used as tools in cell biology to dissect cellular processes or used as therapeutic agents. Novel recombinant toxins are already proposed in the treatment of some diseases, as well as new vaccines. Alternatively, certain toxins are also considered as biological weapons or bioterrorism threats. Given the multifaceted aspects of toxin research and the multidisciplinary approaches adopted, toxins are of great interest in many scientific areas from microbiology, virology, cell biology to biochemistry and protein structure. This new edition is written with a multidisciplinary audience in mind and contains 5 new chapters that reflect the latest research in this area. Other chapters have been combined, deleted and fully revised as necessary to deliver relevant and valuable content. Descriptions of relevant toxins as well as representative toxins of the main bacterial toxin families to allow for a better comparison between them. Focused chapters on toxin applications and common properties or general features of toxins.

The Comprehensive Sourcebook of Bacterial Protein Toxins

The Comprehensive Sourcebook of Bacterial Protein Toxins
Author : John H. Freer,Joseph E. Alouf
Publisher : Unknown
Release Date : 1999
Category : Medical
Total pages :718
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The Comprehensive Sourcebook of Bacterial Protein Toxins, Second Edition, provides an up-to-date description of the great advances made in our understanding of the structure, genetics, cellular, and molecular mechanisms of action of bacterial protein toxins over the past decade. This work follows and expands on the first edition (published in 1991), with 70% totally new content and full-color illustrations. Molecular biology, microbiology, immunology, cell biology, protein engineering, structural biochemistry, and clinical research in infectious diseases are brought together to provide a complete overview of the field. Key Features * Most up-to-date and comprehensive reference on the subject * Addresses recent achievements in basic and applied toxin research * Covers use of bacterial toxins in the development of new vaccines, immunodulators, and therapeutics against cancer and various neurological disorders * Written by internationally recognized scientists, including Randall Holmes, a recent candidate for presidency of the American Society for Microbiology

Sourcebook of Bacterial Protein Toxins

Sourcebook of Bacterial Protein Toxins
Author : Joseph E. Alouf,John H. Freer
Publisher : Unknown
Release Date : 1991
Category : Bacterial protein
Total pages :518
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Written by an international team of leading scientists, this volume draws together a wealth of information on the structure, regulation, and activity of bacterial protein toxins. A comprehensive sourcebook on bacterial toxins, Sourcebook of Bacterial Protein Toxins is the first book designed to draw together current knowledge on these toxins. The 22 chapters of this book have been written by 44 internationally known specialists who have significantly contributed to the progress in the domains covered. This book will appeal to a wide readership, including microbiologists, biochemists, cell biologists, and physicians. It will also arouse the interest of students and scientists in other disciplines who see the power of these fascinating biological agents, either as exquisitely specific probes of cellular processes or as extremely potent agents of infectious disease.

Bacterial Protein Toxins

Bacterial Protein Toxins
Author : K. Aktories,I. Just
Publisher : Springer Science & Business Media
Release Date : 2013-03-14
Category : Medical
Total pages :700
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In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.

Pore-Forming Toxins

Pore-Forming Toxins
Author : Gisou van der Goot
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Science
Total pages :168
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Pore-forming toxins are virulence factors produced by a great variety of pathogenic bacteria ranging from the Gram-positive Staphylococcus aureus to the Gram-negative Helicobacter pylory. The recent studies reviewed in this volume describe the progress that has been made in dissecting the different steps of the mode of action of these proteins which generally include binding to specific cell surface receptors, oligomerization into ring like structures and membrane perforation.

Bacterial Protein Toxins

Bacterial Protein Toxins
Author : Drusilla L. Burns,Joseph T. Barbieri,Barbara H. Iglewski,Rino Rappuoli
Publisher : Amer Society for Microbiology
Release Date : 2003
Category : Medical
Total pages :348
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Details how these proteins work while providing a review of the field. * Describes all aspects of the biology of toxins, including their synthesis and secretion from the bacterial cell, their travels to and into the target host cell, and their modes of attacking the host cell machinery.* Illustrates how bacterial toxins, each of which has distinct individual properties, often share mechanisms of secretion, membrane transport, and enzymatic action.

ADP-Ribosylating Toxins

ADP-Ribosylating Toxins
Author : Klaus Aktories
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Medical
Total pages :148
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ADP-ribosylating toxins have been the focus of intensive research for more than 30 years. Researchers from diverse fields of science have taken an interest in these bacterial toxins; they are studied, for example, by microbiologists, biochemists, cell biologists, and pharmacologists. There are two principal reasons for the broad and still growing interest in ADP ribosylating toxins. First, insights into the structure and functions of the toxins might be the key to prevention and treatment of diseases caused by the toxin-producing infectious micro organisms. Second, the ADP-ribosylating toxins provide potent and often unique pharmacological tools for the study of the physiological functions of their target proteins. The latter is especially the case with cholera and pertussis toxins, which both modify the IX-subunits of heterotrimeric G-proteins involved in signal transduction pathways. These toxins have proved invaluable in extending our basic understanding of the regulation of hormone-controlled signal transduction. This volume provides a review and an update of recent studies on the basic properties of bacterial ADP-ribosylating tbxins and/or exoenzymes. Our current knowledge of the cel lular entry mechanisms of ADP-ribosylating toxins is reviewed by MADSHUS and STENMARK. WILSON and COLLIER then deal with recent insights into the enzyme mechanism and active site structure of diphtheria toxin and Pseudomonas aeruginosa exotoxin A, which modify elongation factor 2. Toxins which ADP-ribosylate heterotrimeric G-proteins involved in trans membrane signal transduction are the subject of the next two chapters.

Pore-forming Peptides and Protein Toxins

Pore-forming Peptides and Protein Toxins
Author : Gianfranco Menestrina,M. Dalla Sera
Publisher : CRC Press
Release Date : 2003-01-30
Category : Medical
Total pages :360
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Pore-forming proteins and peptides play a central role in bacterial pathogenesis, the immune response, defense from venomous attack, and innate immunity. These proteins attack and eliminate other organisms by punching an aqueous channel through their membranes, which disrupts appropriate cell function. The discovery of this cellular interaction has

Botulinum Neurotoxins

Botulinum Neurotoxins
Author : Andreas Rummel,Thomas Binz
Publisher : Springer Science & Business Media
Release Date : 2012-12-14
Category : Medical
Total pages :324
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The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

HIV Chemotherapy

HIV Chemotherapy
Author : Salvatore T. Butera
Publisher : Caister Academic Press Limited
Release Date : 2005
Category : Medical
Total pages :309
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Butera (National Center for HIV, STD, and TB Prevention) gathers international AIDS researchers to review every aspect of HIV chemotherapy. They deal with the clinical management of HIV infections and review current molecular strategies to protect and strengthen host immune systems at the cellular level. The genetics of viral drug resistance and cu

Bacterial Virulence

Bacterial Virulence
Author : Anthony William Maresso
Publisher : Springer Nature
Release Date : 2019-09-05
Category : Medical
Total pages :212
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This textbook introduces in an engaging way the fundamentals of how pathogenic bacteria interact with, and are virulent within, the human host. To inspire and educate the next generation of microbe hunters, the author, Microbiologist and Scientist Anthony William Maresso, integrates the major findings of the field into a single, easy-to-understand volume emphasizing a molecular appreciation of the concepts underlying bacterial infectious diseases. The work explores such themes as the history of Microbiology, bacterial structure and physiology, bacterial toxins, secretion systems, and adhesins, the host immune system and its battle with bacteria, biofilms, sepsis, and technologies/techniques to the present day. Fully illustrated in concept and packed with idea-provoking challenges highlighting “out-of-the-box” thinking, the work moves beyond being just a review of the scientific literature intent on equipping the next generation of Microbiologists and their teachers with the knowledge to confront, and hopefully one day defeat, the insidious microbes which undermine human health. This textbook is a resource for undergraduate, graduate, and medical students, as well as other health-oriented learners, postdoctoral scholars, basic scientists, and professors intent on expanding their knowledge of bacterial infection and virulence mechanisms.

Biology of Disease

Biology of Disease
Author : Nessar Ahmed,Maureen Dawson,Chris Smith,Ed Wood
Publisher : Garland Science
Release Date : 2007-01-24
Category : Science
Total pages :600
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Biology of Disease describes the biology of many of the human disorders and disease that are encountered in a clinical setting. It is designed for first and second year students in biomedical science programs and will also be a highly effective reference for health science professionals as well as being valuable to students beginning medical school. Real cases are used to illustrate the importance of biology in understanding the causes of diseases, as well as in diagnosis and therapy.

Mims' Pathogenesis of Infectious Disease

Mims' Pathogenesis of Infectious Disease
Author : Cedric A. Mims,Anthony A. Nash,John Stephen
Publisher : Gulf Professional Publishing
Release Date : 2001
Category : Medical
Total pages :474
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Infectious diseases are the leading cause of death worldwide, and are increasing in almost every nation, including the United States; they ranked third among the leading causes of death in the U.S. in 1992. Infectious diseases can be caused by bacteria, parasites, viruses, and other microbes such as fungus. They are part of everyday life, and range in severity from strep throat to AIDS. Mims' Pathogenesis of Infectious Disease has been the landmark book in the field. This revised edition provides an up-to-date picture of the global burden of infectious disease. It explains principles clearly and completely, using examples from various infections. It covers the mechanisms for spread of disease, immune response, and recovery, and is ideal as a course text for graduate and undergraduate students. New features include: * Microbial gene sequencing * Role of bacterial virulence factors in vivo * Latest data on tuberculosis - the number one infectious disease worldwide * Role of pathogenic cytokines * Significance of toxins * An update on vaccines, prions, immune evasion, microbial ligands and receptors

Listeria monocytogenes: Pathogenesis and Host Response

Listeria monocytogenes: Pathogenesis and Host Response
Author : Howard Goldfine,Hao Shen
Publisher : Springer Science & Business Media
Release Date : 2007-06-24
Category : Science
Total pages :287
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During the past twenty years Listeria monocytogenes has emerged as one of the most intensely studied bacterial pathogens. New windows are constantly being opened into the complexity of host cell biology and the interplay of the signals connecting the various cells and organs involved in the host response. This volume includes research from studies at the molecular level on the pathogenesis of Listeria monocytogenes and the response of the host to its infections.