May 6, 2021

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The Cytokines of the Immune System

The Cytokines of the Immune System
Author : Zlatko Dembic
Publisher : Academic Press
Release Date : 2015-05-23
Category : Medical
Total pages :320
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The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. Supplies new ideas for basic and clinical research Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials Offers a textbook-style view on the immune system with the immunologic role of each cytokine

The Cytokines of the Immune System

The Cytokines of the Immune System
Author : Zlatko Dembic
Publisher : Academic Press
Release Date : 2015-05-01
Category : Medical
Total pages :320
GET BOOK

The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. Supplies new ideas for basic and clinical research Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials Offers a textbook-style view on the immune system with the immunologic role of each cytokine

Cytokines

Cytokines
Author : Robert E. Faith,Anthony J. Murgo,Robert A. Good,Nicholas P. Plotnikoff
Publisher : CRC Press
Release Date : 2006-10-10
Category : Medical
Total pages :405
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Cytokine involvement in the immune system's response to stress is now very well documented. Cytokine activity has been implicated in a variety of mental and physical diseases, and has been shown to have a significant role in fueling the vicious circle of depression and illness. The first edition of Cytokines: Stress and Immunity pointed out

Cytokine Frontiers

Cytokine Frontiers
Author : Takayuki Yoshimoto,Tomohiro Yoshimoto
Publisher : Springer Science & Business Media
Release Date : 2013-10-28
Category : Medical
Total pages :396
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This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.

Janeway's Immunobiology

Janeway's Immunobiology
Author : Murphy, Kenneth M.,Weaver, Casey
Publisher : W.W. Norton & Company
Release Date : 2016-03-22
Category : Medical
Total pages :904
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Explore the premier text for immunology at the advanced undergraduate, graduate, and medical school levels. Beginning students appreciate the bookÕs clear writing and informative illustrations, while advanced students and working immunologists value its comprehensive scope and depth. This edition is thoroughly revised and up to date with significant developments in the field, especially on the topic of innate immunity.

Immunoregulatory Aspects of Immunotherapy

Immunoregulatory Aspects of Immunotherapy
Author : Seyyed Shamsadin Athari
Publisher : BoD – Books on Demand
Release Date : 2018-08-01
Category : Medical
Total pages :240
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Immunotherapy is an innovative, leading and valuable approach to the treatment and control of many diseases. It can solve many problems of public health worldwide. Many people in numerous countries are suffering from a wide range of diseases (communicable and non-communicable) that can be cured or controlled by the immune system and immunotherapy. Some immunological diseases (i.e. allergic reactions and asthma, autoimmune disease, immunodeficiency disease, hypersensitivity reactions, etc.) have immune response pathophysiology and by controlling immune system mechanisms, these diseases can be controlled and cured. Immunoregulatory Aspects of Immunotherapy focuses on immune system mechanism, diagnosis, treatment and other related problems. The chapters have applicable and scientific data in immunotherapeutic approaches based on medical sciences, and would be of benefit to all researchers in immunology, allergy and asthma fields. The book discusses the prevention, diagnosis, treatment and follow-up of patients who have dangerous diseases. We hope this book will be a new approach to the immunotherapy of diseases and will improve public health and wellbeing.

Adverse Effects of Vaccines

Adverse Effects of Vaccines
Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee to Review Adverse Effects of Vaccines
Publisher : National Academies Press
Release Date : 2012-04-26
Category : Medical
Total pages :894
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In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

Molecular Biology of the Cell

Molecular Biology of the Cell
Author : Bruce Alberts
Publisher : Unknown
Release Date : 2004
Category :
Total pages :129
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Military Strategies for Sustainment of Nutrition and Immune Function in the Field

Military Strategies for Sustainment of Nutrition and Immune Function in the Field
Author : Committee on Military Nutrition Research,Institute of Medicine
Publisher : National Academies Press
Release Date : 1999-05-27
Category : Medical
Total pages :693
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Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.

Cytokine Storm Syndrome

Cytokine Storm Syndrome
Author : Randy Q. Cron,Edward M. Behrens
Publisher : Springer Nature
Release Date : 2019-09-09
Category : Medical
Total pages :617
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Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.

Cytokines and Pain

Cytokines and Pain
Author : L.R. Watkins,S.F. Maier
Publisher : Springer
Release Date : 2013-03-08
Category : Medical
Total pages :232
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Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.

Cytokines, Stress, and Depression

Cytokines, Stress, and Depression
Author : Robert Dantzer,Emmanuelle E. Wollmann,Raz Yirmiya
Publisher : Springer Science & Business Media
Release Date : 2007-11-23
Category : Medical
Total pages :338
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Cytokines had been characterized in the early eighties as communication mole cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between cytokines and inflammation, and the demonstration of a pivotal role of some of these molecules in cell death by apoptosis, prompted the investigation of their involvement in several neurological diseases involving an inflammatory component, including multiple sclerosis, brain trauma, stroke, and Alzheimer's disease. This movement started in the late eighties, and the corresponding field of research, known as neuroimmunology, is presently booming. In psychiatry, however, the relationship between cytokines and mental disorders was much less evident and took longer to materialize. The first indication that cytokines might be involved in psychopathology came from cancerology and internal medicine.

Recent Developments in Myelodysplastic Syndromes

Recent Developments in Myelodysplastic Syndromes
Author : Ota Fuchs
Publisher : BoD – Books on Demand
Release Date : 2019-02-20
Category : Medical
Total pages :120
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This book deals with the rapid progress in the area of myelodysplastic syndromes (MDS). MDS are a group of age-associated heterogeneous malignant bone marrow stem cell disorders. MDS are characterized by ineffective hematopoiesis, which leads to refractory cytopenias and to clonal instability. Patients with MDS have myeloid dysplasia, intramedullary apoptosis and an increased risk of transformation to acute myeloid leukemia (AML). The use of next generation sequencing has allowed for the identification of molecular mutations in several genes in about 90% of MDS patients. Several mutations will likely be incorporated into future prognostic scoring systems for MDS. About 50% of MDS cases are characterized by the presence of cytogenetic abnormalities. The correct morphological and cytogenetic analysis interpretation plays an important role in diagnosis and prognosis of these disorders. Cell death and an inflammatory gene signature are associated with MDS. Better understanding of the genetic and molecular mechanisms of MDS pathogenesis provides an opportunity for new treatment strategies to be developed. Promising novel therapies targeting pathophysiological mechanisms of MDS are being studied but the drugs currently used in MDS therapy remain limited. The only curative therapy for MDS is allogeneic hematopoietic stem cell transplantation. Recent advances in strategies to minimize transplant-related toxicity make this treatment possible for more MDS patients who are sufficiently fit.

Cytokines

Cytokines
Author : Victor R. Preedy,Ross Hunter
Publisher : CRC Press
Release Date : 2011-06-24
Category : Medical
Total pages :450
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Cytokines are a group of peptides secreted by cells of the immune system such as macrophages, lymphocytes, and T cells. They can be divided into functional families and have-wide ranging impacts that affect cells and molecular pathways to the whole individual. Written by distinguished scholars and experts, this book is a holistic reference to enable scientists and doctors to understand cytokines in specific or broad detail. The book is divided into sections that cover general and cellular aspects, lifestyle factors, immunology and infections, cancer, cardiovascular and metabolic disease, and organs and tissue systems.

Principles of Cancer Biotherapy

Principles of Cancer Biotherapy
Author : Robert K. Oldham,Robert O. Dillman
Publisher : Springer Science & Business Media
Release Date : 2009-08-29
Category : Medical
Total pages :742
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At the time of the first edition of Principles of Cancer Biotherapy in 1987, this book represented the first comprehensive textbook on biological therapy. In 1991, when the second edition was published, there was still some doubt on the part of many oncologists and cancer researchers as to the therapeutic value of these new approaches. By 2003 and the fourth edition, it was generally agreed that biopharmaceuticals were producing major opportunities for new cancer therapies. Cancer biotherapy has now truly matured into the fourth modality of cancer treatment. This fifth revised edition describes the tremendous progress that has been made in recent years using biologicals in cancer treatment. This book summarizes an evolving science and a rapidly changing medical practice in biotherapy. In this new millennium, it is now possible to envision a much more diversified system of cancer research and treatment that will afford greater opportunities for a patient’s personalized cancer treatment. This was first envisioned in the 1987 initial edition of this textbook and is now a “new” and popular approach to cancer treatment. Some forms of cancer biotherapy use the strategy of tumor stabilization and control through continued biological therapy, akin to the use of insulin in the treatment of diabetes. This textbook illustrates new methods of thinking and new strategies for control of cancer. It is always difficult to move from past dogma to future opportunity, but this fifth edition of Principles of Cancer Biotherapy illustrates why it is so important to the patients for researchers and clinicians to explore and quickly apply these new opportunities in cancer biotherapy.