November 28, 2020

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Immunosensing for Detection of Protein Biomarkers

Immunosensing for Detection of Protein Biomarkers
Author : Huangxian Ju,Guosong Lai,Feng Yan
Publisher : Elsevier
Release Date : 2017-05-18
Category : Science
Total pages :304
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Immunosensing for Detection of Protein Biomarkers not only introduces the principles, methods, and classification of immunoassay, but also presents the latest achievements in areas such as electrochemical immunosensors, nanoprobe-based immunoassay, chemiluminescence immunoassay, electrochemiluminescent immunoassay, multianalyte immunoassay, optical imaging for immunoassay, signal amplification for immunoassay, and so on. In recent years, immunosensing and immunoassay methods have attracted considerable interest due to their applications in different fields, particularly clinical diagnosis. Although a large number of academic papers in immunosensing and immunoassay have been published in different journals recently, it is still a difficult and time-consuming task for researchers, especially those new to the area, to understand the principles, methods, and research progress of immunosensing. Based on the research experience of the authors and their research groups, this book offers readers with new research ideas to develop immunosensing methodology. As a monograph, it offers deeper and more complete coverage than review papers, which only report certain aspects of progress. Grounded in the research experience of Professor Ju’s research group, the book focuses on immunosensing for detection of protein biomarkers, summarizing understanding, research, and practice on immunosensing methodology in detection of protein biomarkers. Presents the latest research and thinking on immunosensing for detection of protein biomarkers Offers current techniques, and looks to the development of new methodologies Offers the latest developments in various aspects of immunosensing, including electrochemiluminescent immunoassay, multianalyte immunoassay, optical imaging immunoassay, and signal amplification immunoassay Offers readers new ideas to research and develop immunosensing methodologies for the future

Biomarkers and Biosensors

Biomarkers and Biosensors
Author : Ajit Sadana,Neeti Sadana
Publisher : Newnes
Release Date : 2014-12-08
Category : Science
Total pages :702
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Biomarkers and Biosensors offers thorough coverage of biomarker/biosensor interaction, current research trends, and future developments in applications of drug discovery. This book is useful to researchers in this field as well as clinicians interested in new developments in early detection and diagnosis of disease or the mode of operation of biomarkers. Biomarkers and Biosensors also emphasizes kinetics, and clearly delineates how this influences the biomarker market. Offers thorough coverage of the kinetics of biomarker interaction with the biosensor surface Provides evidence-based approach to evaluate effectiveness Provides pharmaceutical chemists the possibilities and methodology in assessing the effectiveness of new drugs Provides the information needed for the selection of the best biomarker for a specific application

Biomarkers in Cancer Screening and Early Detection

Biomarkers in Cancer Screening and Early Detection
Author : Sudhir Srivastava
Publisher : John Wiley & Sons
Release Date : 2017-06-07
Category : Medical
Total pages :320
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Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment. Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers Provides immediately actionable information – and hopefully also inspiration – to move discovery and clinical application forward Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers

Developing Affimers for the Detection of Biomarkers in Cancer

Developing Affimers for the Detection of Biomarkers in Cancer
Author : Danah A. A. A. Q. Al-Qallaf
Publisher : Unknown
Release Date : 2018
Category :
Total pages :129
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Early Detection of Biomarkers for Disease

Early Detection of Biomarkers for Disease
Author : Richard Morgan,Nicholas Hoyle
Publisher : Unknown
Release Date : 2014-03-01
Category : Technology & Engineering
Total pages :250
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This volume presents the current knowledge on biomarkers for the early detection of disease, and the methodologies used for detecting these biomarkers, often present at very low concentrations in bodily fluids.

Biomarkers for the Detection, Prognois and Evaluation of Active Tuberculosis

Biomarkers for the Detection, Prognois and Evaluation of Active Tuberculosis
Author : Anonim
Publisher : Unknown
Release Date : 2010
Category :
Total pages :129
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The global TS surveillance workshop aims to address the problems with current methods for the detection of TB, and tracking emergence of resistant strains. The purpose of the attached presentation is to review the current methods in the detection of pathogen biomarkers for TB and if that technology has promise for diagnosis of TB. A summary of three biomarkers and some data on their detection strategies is presented. Some of the work is from LANL work but much of it is derived from literature references on the subject.

Nanobiosensors

Nanobiosensors
Author : Aiguo Wu,Waheed S. Khan
Publisher : John Wiley & Sons
Release Date : 2020-06-02
Category : Science
Total pages :416
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Containing cutting edge research on the hot topic of nanobiosensor, this book will become highly read Biosensor research has recently re-emerged as most vibrant area in recent years particularly after the advent of novel nanomaterials of multidimensional features and compositions. Nanomaterials of different types and striking properties have played a positive role in giving the boost and accelerated pace to biosensors development technology. Nanobiosensors - From Design to Applications covers several aspects of biosensors beginning from the basic concepts to advanced level research. It will help to bridge the gap between various aspects of biosensors development technology and applications. It covers biosensors related material in broad spectrum such as basic concepts, biosensors & their classification, biomarkers & their role in biosensors, nanostructures-based biosensors, applications of biosensors in human diseases, drug detection, toxins, and smart phone based biosensors. Nanobiosensors - From Design to Applications will prove a source of inspiration for research on biosensors, their local level development and consequently using for practical application in different industries such as food, biomedical diagnosis, pharmaceutics, agriculture, drug discovery, forensics, etc. * Discusses the latest technology and advances in the field of nanobiosensors and their applications in human diseases, drug detection, toxins * Offers a broad and comprehensive view of cutting-edge research on advanced materials such as carbon materials, nitride based nanomaterials, metal and metal oxide based nanomaterials for the fast-developing nanobiosensors research * Goes to a wide scientific and industry audience Nanobiosensors - From Design to Applications is a resource for polymer chemists, spectroscopists, materials scientists, physical chemists, surface chemists, and surface physicists.

In Vitro Biomarker Detection for Early Diagnosis of Neurodegenerative Diseases Via the Ocular Fluid

In Vitro Biomarker Detection for Early Diagnosis of Neurodegenerative Diseases Via the Ocular Fluid
Author : Parisa Farajipour
Publisher : Unknown
Release Date : 2009
Category : Amyloid
Total pages :87
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"Non invasive early diagnosis of any disease is a crucial step in prevention, treatment and decreasing the mortality rate. The purpose of this study is in vitro screening of neurodegenerative disease biomarkers, employing polarimetric detection methodology via ocular fluid. According to Dr. Ansari 'eye can be considered, not only a window to the soul but a window to the body'2. The eye is easily accessed by light for in vitro imaging and screening of diseases. The unique biomarkers exist in the ocular fluid for large groups of diseases, which can determine the presence and the stage of the disease. For this research Amyloid, Vascular Endothelial Growth Factor and Glutamate biomarkers have been studied for in vitro detection of neurodegenerative diseases. The concentration elevation of any of these biomarkers may highlight the presence and progression rate of certain neurodegenerative diseases. The potential of in vitro spectral and power analysis of optical biomarkers, under two distinct geometries: a) Backscattered geometry; and b) Diffused reflectance geometry, to detect unique optical signatures has been investigated. The copolarized and crosspolarized contributions were achieved by spectrometer and power meter, and the corresponding Degree of Linear Polarization (DOLP) were calculated. Backscattering geometry detected light from the surface and subsurface of the tissue (epithelium), therefore it was anticipated to be highly polarized. Diffused reflectance geometry detected light from deeper structures therefore, light contributions were mostly unpolarized due to multiple scattering. The combination of the data collected utilizing both geometries may reveal more inclusive information, by not solely reaching the surface of the target, but also deeper depth of the target. Bot spectral and power analysis of various concentrations of each biomarker revealed a variation of the degree of linear polarization (DOLP) with increments in biomarker concentration. The coefficient of variation between multiple measurements were negligible and there was a consistency between repetitions. The statistical analysis of power and spectral responses illustrated a significant difference in DOLP by varying biomarker concentration, which can be utilized for early diagnosis of neurodegenerative diseases."--Abstract.

Role of Biomarkers in Medicine

Role of Biomarkers in Medicine
Author : Mu Wang,Frank Witzmann
Publisher : BoD – Books on Demand
Release Date : 2016-08-17
Category : Medical
Total pages :260
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The use of biomarkers in basic and clinical research has become routine in many areas of medicine. They are accepted as molecular signatures that have been well characterized and repeatedly shown to be capable of predicting relevant disease states or clinical outcomes. In Role of Biomarkers in Medicine, expert researchers in their individual field have reviewed many biomarkers or potential biomarkers in various types of diseases. The topics address numerous aspects of medicine, demonstrating the current conceptual status of biomarkers as clinical tools and as surrogate endpoints in clinical research. This book highlights the current state of biomarkers and will aid scientists and clinicians to develop better and more specific biomarkers for disease management.

Biomarkers in Toxicology

Biomarkers in Toxicology
Author : Ramesh C. Gupta
Publisher : Academic Press
Release Date : 2019-02-13
Category : Medical
Total pages :1246
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Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields. Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers Includes completely revised chapters, along with additional chapters on the newest developments in the field Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more

The Limits of Organic Life in Planetary Systems

The Limits of Organic Life in Planetary Systems
Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Division on Engineering and Physical Sciences,Space Studies Board,Committee on the Origins and Evolution of Life,Committee on the Limits of Organic Life in Planetary Systems
Publisher : National Academies Press
Release Date : 2007-07-26
Category : Science
Total pages :116
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The search for life in the solar system and beyond has to date been governed by a model based on what we know about life on Earth (terran life). Most of NASA's mission planning is focused on locations where liquid water is possible and emphasizes searches for structures that resemble cells in terran organisms. It is possible, however, that life exists that is based on chemical reactions that do not involve carbon compounds, that occurs in solvents other than water, or that involves oxidation-reduction reactions without oxygen gas. To assist NASA incorporate this possibility in its efforts to search for life, the NRC was asked to carry out a study to evaluate whether nonstandard biochemistry might support life in solar system and conceivable extrasolar environments, and to define areas to guide research in this area. This book presents an exploration of a limited set of hypothetical chemistries of life, a review of current knowledge concerning key questions or hypotheses about nonterran life, and suggestions for future research.

Cancer Biomarkers

Cancer Biomarkers
Author : Alexandros G Georgakilas
Publisher : CRC Press
Release Date : 2012-11-19
Category : Medical
Total pages :382
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This unique synthesis of chapters from top experts in their fields targets the essential area of cancer biomarkers and the need for better and more rigorous design and clinical trials. The contributors cover several aspects of cancer molecular markers from innovation and screening to their controversies and future directions. The book is an ideal r

Early Detection of Cancer

Early Detection of Cancer
Author : Sudhir Srivastava
Publisher : IOS Press
Release Date : 2005
Category : Medical
Total pages :98
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Technological inventions allow us to identify molecular events that will effectively detect cancer earlier in biological specimens. This approach enables us to develop molecular biomarkers for detecting cancer early. It is believed that such a molecular marker approach enables the detection of the disease earlier.

Cancer Biomarkers

Cancer Biomarkers
Author : Institute of Medicine,Committee on Developing Biomarker-Based Tools for Cancer Screening, Diagnosis, and Treatment
Publisher : National Academies Press
Release Date : 2007-03-27
Category : Medical
Total pages :250
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Many cancer patients are diagnosed at a stage in which the cancer is too far advanced to be cured, and most cancer treatments are effective in only a minority of patients undergoing therapy. Thus, there is tremendous opportunity to improve the outcome for people with cancer by enhancing detection and treatment approaches. Biomarkers will be instrumental in making that transition. Advances in biotechnology and genomics have given scientists new hope that biomarkers can be used to improve cancer screening and detection, to improve the drug development process, and to enhance the effectiveness and safety of cancer care by allowing physicians to tailor treatment for individual patients—an approach known as personalized medicine. However, progress overall has been slow, despite considerable effort and investment, and there are still many challenges and obstacles to overcome before this paradigm shift in oncology can become a reality.

Biomarkers in Drug Development

Biomarkers in Drug Development
Author : Michael R. Bleavins,Claudio Carini,Mallé Jurima-Romet,Ramin Rahbari
Publisher : John Wiley & Sons
Release Date : 2011-09-20
Category : Medical
Total pages :784
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Discover how biomarkers can boost the success rate of drugdevelopment efforts As pharmaceutical companies struggle to improve the success rateand cost-effectiveness of the drug development process, biomarkershave emerged as a valuable tool. This book synthesizes and reviewsthe latest efforts to identify, develop, and integrate biomarkersas a key strategy in translational medicine and the drugdevelopment process. Filled with case studies, the bookdemonstrates how biomarkers can improve drug development timelines,lower costs, facilitate better compound selection, reducelate-stage attrition, and open the door to personalizedmedicine. Biomarkers in Drug Development is divided into eightparts: Part One offers an overview of biomarkers and their role in drugdevelopment. Part Two highlights important technologies to help researchersidentify new biomarkers. Part Three examines the characterization and validation processfor both drugs and diagnostics, and provides practical advice onappropriate statistical methods to ensure that biomarkers fulfilltheir intended purpose. Parts Four through Six examine the application of biomarkers indiscovery, preclinical safety assessment, clinical trials, andtranslational medicine. Part Seven focuses on lessons learned and the practical aspectsof implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including dataintegration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or moreleading experts, including scientists from biotechnology andpharmaceutical firms, academia, and the U.S. Food and DrugAdministration. Their contributions offer pharmaceutical andclinical researchers the most up-to-date understanding of thestrategies used for and applications of biomarkers in drugdevelopment.