November 27, 2020

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The Mouse in Biomedical Research

The Mouse in Biomedical Research
Author : Anonim
Publisher : Elsevier
Release Date : 2006-12-04
Category : Science
Total pages :352
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History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.

The Mouse in Biomedical Research

The Mouse in Biomedical Research
Author : Henry L. Foster,J. David Small,James G. Fox
Publisher : Unknown
Release Date : 1981
Category : Medical
Total pages :390
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The Mouse in Biomedical Research

The Mouse in Biomedical Research
Author : Henry Foster
Publisher : Elsevier
Release Date : 1981-01-01
Category : Science
Total pages :320
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The Mouse in Biomedical Research, Volume I: History, Genetics, and Wild Mice focuses on the utility of the mouse as a laboratory animal in biomedical research. A historical perspective on the development and origins of the laboratory and wild mouse is given. The diversity of inbred strains of mice as well as the methods of developing and the genetic monitoring and testing of these strains are discussed. This volume consists of 14 chapters and begins with an overview of mice of the genus Mus and problems concerning evolution within the genus. The following chapters focus on taxonomy, nomenclature, and breeding systems, together with recombinant inbred and congenic resistant mouse strains. Methods of constructing, testing, and monitoring strains are described. Congenic strains, gene mapping, cytogenetics, and murine experimental studies are also considered, along with the histocompatibility-2 complex and radiation genetics. The final chapter is devoted to the pharmacogenetics of the laboratory mouse, paying particular attention to intoxication and detoxication pathways, genetically determined differences in xenobiotic metabolism, and pharmacogenetic polymorphisms. This book will be a useful reference for investigators using mice in many areas of research.

The Mouse in Biomedical Research: Experimental biology and oncology

The Mouse in Biomedical Research: Experimental biology and oncology
Author : Henry L. Foster,J. David Small,James G. Fox
Publisher : Unknown
Release Date : 1981
Category : Medicine, Experimental
Total pages :561
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The Mouse in Biomedical Research

The Mouse in Biomedical Research
Author : Henry L. Foster,J. David Small,James C.. Fox,James G. Fox
Publisher : Unknown
Release Date : 1983
Category : Medicine, Experimental
Total pages :447
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Gnotobiotics. Management and design of breeding. design and management of research facilities for mice. Nutrition. Animal health survellance and health delivery systems. Environmental and equipment monitoring. Anatomy. Embryology. Reproductive physiology. Endocrinology. Physiology. Hematology. Clinical biochemistry. Gastrointestinal microflora. Immunoglobulin genes. Lymphocyte immunogenetics. Immune response desorders normal tolal. Biomethodology and surgical techniques.

Making Mice

Making Mice
Author : Karen Rader
Publisher : Princeton University Press
Release Date : 2004-03-21
Category : Science
Total pages :299
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Making Mice blends scientific biography, institutional history, and cultural history to show how genetically standardized mice came to play a central role in contemporary American biomedical research. Karen Rader introduces us to mouse "fanciers" who bred mice for different characteristics, to scientific entrepreneurs like geneticist C. C. Little, and to the emerging structures of modern biomedical research centered around the National Institutes of Health. Throughout Making Mice, Rader explains how the story of mouse research illuminates our understanding of key issues in the history of science such as the role of model organisms in furthering scientific thought. Ultimately, genetically standardized mice became icons of standardization in biomedicine by successfully negotiating the tension between the natural and the man-made in experimental practice. This book will become a landmark work for its understanding of the cultural and institutional origins of modern biomedical research. It will appeal not only to historians of science but also to biologists and medical researchers.

Sourcebook of Models for Biomedical Research

Sourcebook of Models for Biomedical Research
Author : P. Michael Conn
Publisher : Springer Science & Business Media
Release Date : 2008
Category : Medical
Total pages :778
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The collection of systems represented in this volume is a unique effort to reflect the diversity and utility of models used in biomedicine. That utility is based on the consideration that observations made in particular organisms will provide insight into the workings of other, more complex systems. This volume is therefore a comprehensive and extensive collection of these important medical parallels.

The Laboratory Mouse

The Laboratory Mouse
Author : Hans Hedrich
Publisher : Academic Press
Release Date : 2012-06-14
Category : Science
Total pages :868
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The Laboratory Mouse, Second Edition is a comprehensive book written by international experts. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. This well-illustrated edition offers new and updated chapters including immunology, viruses and parasites, behavior, enrichment and care standards of laboratory mice across the life sciences, medical and veterinary fields. Features four-color illustrations with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research Offers additional chapters on new mouse strains, phenotyping of strains, bacteria and parasites, and immunology Includes the newly revised EU standards on care, as well as, comparisons to standards and regulations in the US and other countries

Cellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research
Author : Anonim
Publisher : Academic Press
Release Date : 2019-07-30
Category : Medical
Total pages :226
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Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

The Mouse in Biomedical Research: History, genetics, and wild mice

The Mouse in Biomedical Research: History, genetics, and wild mice
Author : Henry L. Foster,J. David Small,James G. Fox,James G Fox
Publisher : Unknown
Release Date : 1981
Category : Medical
Total pages :306
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A Practical Guide to the Histology of the Mouse

A Practical Guide to the Histology of the Mouse
Author : Cheryl L. C. Scudamore
Publisher : John Wiley & Sons
Release Date : 2014-02-10
Category : Medical
Total pages :248
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A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues. This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions. This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology. Written by experienced pathologists and specifically tailored to the needs of scientists and histologists Full colour throughout Provides advice on sampling tissues, necropsy and recording data Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation

The Minipig in Biomedical Research

The Minipig in Biomedical Research
Author : Peter A. McAnulty,Anthony D. Dayan,Niels-Christian Ganderup,Kenneth L. Hastings
Publisher : CRC Press
Release Date : 2011-12-19
Category : Medical
Total pages :662
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The Minipig in Biomedical Research is a comprehensive resource for research scientists on the potential and use of the minipig in basic and applied biomedical research, and the development of drugs and chemicals. Written by acknowledged experts in the field, and drawing on the authors’ global contacts and experience with regulatory authorities and the pharmaceutical and other industries, this accessible manual ranges widely over the biological, scientific, and practical uses of the minipig in the laboratory. Its coverage extends from the minipig’s origins, anatomy, genetics, immunology, and physiology to its welfare, health, and husbandry; practical dosing and examination procedures; surgical techniques; and all areas of toxicity testing and the uses of the minipig as a disease model. Regulatory aspects of its use are considered. The reader will find an extensive amount of theoretical and practical information in the pharmacology; ADME and toxicology chapters which will help scientists and managers when deciding which species to use in basic research; drug discovery and pharmacology; and toxicology studies of chemicals, biotechnology products and devices. The book discusses regulatory uses of minipigs in the evaluation of human and veterinary pharmaceuticals, medical devices, and other classes of xenobiotics. It describes features of normal health, normal laboratory values, and common diseases. It also carefully elucidates ethical and legal considerations in their supply, housing, and transport. The result is an all-inclusive and up to date manual about the experimental uses of the minipig that describes ‘How to’ and ‘Why’ and ’What to expect in the normal’, combining enthusiasm and experience with critical assessment of its values and potential problems.

Mouse as a Model Organism

Mouse as a Model Organism
Author : Cord Brakebusch,Taina Pihlajaniemi
Publisher : Springer Science & Business Media
Release Date : 2011-03-29
Category : Medical
Total pages :165
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Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gene mutations, the mouse has become the favourite mammalian model organism to study in vivo function of genes during development and in disease. This book combines review articles on selected subjects presented at the symposium “Mouse as a Model Organism – From Animals to Cells”, held in Rovaniemi, Finland, 2009. Among other topics, high-throughput phenotyping of mouse mutants, mouse phenotypes dependent on nature and nuture, and a spectrum of in vivo, ex vivo and in vitro methods to study cancer in mice are described. This book will give an excellent introduction to scientists interested in the use of mice as a model to understand complex biological questions in the post-genomic era. It will highlight the possibilities, but also discuss the current problems and shortcomings, to give a realistic view of the current state-of-art in this fascinating field of biomedical research.

The Mouse in Biomedical Research: Experimental biology and oncology

The Mouse in Biomedical Research: Experimental biology and oncology
Author : James G. Fox,J. David Small,Henry L. Foster
Publisher : Unknown
Release Date : 1983
Category : Mice as laboratory animals
Total pages :129
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Genetics in Wild Mice

Genetics in Wild Mice
Author : Kazuo Moriwaki,Toshihiko Shiroishi,Hiromichi Yonekowa
Publisher : S Karger Ag
Release Date : 1994
Category : Science
Total pages :333
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