June 20, 2021

Download Ebook Free The Role Of 5-HT Systems On Memory And Dysfunctional Memory

The Role of 5-HT Systems on Memory and Dysfunctional Memory

The Role of 5-HT Systems on Memory and Dysfunctional Memory
Author : Alfredo Meneses
Publisher : Academic Press
Release Date : 2014-03-11
Category : Science
Total pages :92
GET BOOK

Drugs acting through 5-HT (5-hydroxytryptamine, or serotonin) systems modulate memory and its alterations, but the mechanisms by which they do so are poorly understood. Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations reviews and summarizes the most recent research related to 5-HT drugs and the mechanisms by which they effect alterations in memory. This latest evidence is reviewed in the context of memory deficits related to brain disorders, such as post-traumatic stress disorder, schizophrenia, post-stroke cognitive dysfunctions, Parkinson’s disease, and infection-induced memory impairments. Written by an expert in the field of memory, The Role of 5-HT Systems on Memory and Dysfunctional Memory provides an introduction to the latest research on 5-HT receptors and their contributions to the physiological and pharmacological basis of memory. Examines and summarizes the recent advances in drugs that act through the 5-HT systems Reviews findings in the context of brain disorders that involve memory deficits Covers emergent targets for memory formation and memory alterations

Serotonin and Memory

Serotonin and Memory
Author : Alfredo Meneses,Antonella Gasbarri
Publisher : Frontiers Media SA
Release Date : 2016-04-01
Category : Electronic book
Total pages :129
GET BOOK

The study of 5-hydroxytryptamine (5-HT) systems has benefited from the identification, classification and cloning of multiple 5-HT receptors (5-HT1 to 5-HT7). Increasing evidence suggests that 5-HT pathways, reuptake site/transporter complex and 5-HT receptors represent a strategic distribution for learning and memory. A key question still remaining is whether 5-HT markers (e.g., receptors) are directly or indirectly contributing to the physiological and pharmacological basis of memory and its pathogenesis or, rather, if they represent protective or adaptable mechanisms. Certainly, Alzheimer´s disease (AD) is a very complex neuropsychiatric disorder, where memory becomes progressively dysfunctional resulting in amnesia and dementia, whereas forgetting is a physiological phenomenon occurring all the time as adaptive mechanism. As dysfunctional memory occurs in several neuropsychiatric disorders, including schizophrenia, stroke, post-traumatic stress disorder. Hence, the aim of this call is collect recent and important findings related to information about serotonin and memory or 5-HT and learning or 5-HT and memory or serotonin and learning.

Identification of Neural Markers Accompanying Memory

Identification of Neural Markers Accompanying Memory
Author : Alfredo Meneses
Publisher : Elsevier
Release Date : 2013-11-23
Category : Psychology
Total pages :180
GET BOOK

Identification of Neural Markers Accompanying Memory is a fresh and novel volume of memory study, providing up-to-date and comprehensive information for both students and researchers focused on the identification of neural markers accompanying memory. Contributions by experts in specific areas of memory study provide background on and definitions of memory, memory alterations, and the brain areas involved in memory and its related processes, such as consolidation, retrieval, forgetting, amnesia, and antiamnesiac effects. With coverage of the principal neurotransmitters related to memory, brain disorders presenting memory alterations, and available treatments—and with discussion of neural markers as new targets for the treatment of memory alterations—Identification of Neural Markers Accompanying Memory is a necessary and timely work for researchers in this growing field. Discusses the alterations of memory in diverse diseases Includes coverage from a basic introduction of memory investigation Reviews brain areas and neurotransmitters involved in memory Discusses behavioral models of memory Contains novel insights into the complexity of signaling and memory Includes the neuropharmacological and neurobiological bases of memory

Canadian Journal of Physiology and Pharmacology

Canadian Journal of Physiology and Pharmacology
Author : Anonim
Publisher : Unknown
Release Date : 2002
Category : Pharmacology
Total pages :129
GET BOOK

Clinical and Pharmacological Studies in Psychiatric Disorders

Clinical and Pharmacological Studies in Psychiatric Disorders
Author : Graham D. Burrows,Trevor R. Norman,Collegium Internationale Neuro-psychopharmacologicum. Congress,Lorraine Dennerstein
Publisher : Unknown
Release Date : 1985
Category : Man - Mental disorders - Drug therapy
Total pages :394
GET BOOK

Serotonin in the Central Nervous System and Periphery

Serotonin in the Central Nervous System and Periphery
Author : Akikazu Takada,Gerald Curzon
Publisher : Elsevier Science Limited
Release Date : 1995
Category : Medical
Total pages :260
GET BOOK

This work contains contributions on the progress of serotonin research. On the central nervous system, papers deal with topics such as 5-HT receptors and animal models of anxiety; in the periphery, the roles of 5-HT and effects of antagonists of 5-HT receptors in the circulation are presented.

Animal Behaviour Abstracts

Animal Behaviour Abstracts
Author : Anonim
Publisher : Unknown
Release Date : 2001
Category : Animal behavior
Total pages :129
GET BOOK

Dissertation Abstracts International

Dissertation Abstracts International
Author : Anonim
Publisher : Unknown
Release Date : 2008
Category : Dissertations, Academic
Total pages :129
GET BOOK

The Triptans

The Triptans
Author : Patrick Humphrey,M. D. Ferrari,Jes Olesen
Publisher : Frontiers in Headache Research
Release Date : 2001
Category : Medical
Total pages :341
GET BOOK

A new era in the treatment of migraine headache arrived with development of a revolutionary class of drugs known as the triptans. The book describes the development in this class of drugs, starting with the discovery of sumatriptin, covers the pharmacology and the mechanisms of action of the full range of triptans, before comparing their clinical efficacy and tolerability. Each drug is described by the company who produces it and then reviewed, based on experimental and clinical evidence, by independent scientists. This comprehensive review will provide clinicians with guidance on which triptan to select for which patient. The editors have gathered together the leading international experts to produce a book that will appeal to all neurologists and general physicians caring for headache patients as well as those with research interests in the field.

Cognition and Mood Interactions

Cognition and Mood Interactions
Author : Miao-Kun Sun
Publisher : Nova Science Pub Incorporated
Release Date : 2005
Category : Psychology
Total pages :229
GET BOOK

Interaction between cognition and mood regulation is a common neural and behavioural phenomenon. This book brings together an international group of neuroscientists who are investigating neural and molecular mechanisms underlying cognition, mood, and interactions between cognition and mood. Exciting advances are occurring in the understanding of the neural and molecular link between dementia and depression. This unique book provides a comprehensive overview of cognitive and mood neurosciences, with a strong emphasis on interactions between dementia and depression. It begins with an introduction to the fundamental concepts of dementia and depression and core issues facing clinical and neurological investigators. Then, several chapters cover the neurochemical substrates underlying the manifestation of cognition and mood regulation, including monoamines, excitatory amino acids, and angiotensins. Separate chapters are devoted to animal models of human dementia and behavioural changes in Alzheimer's dementia, the most common cause of progressive decline of cognition in aged humans. Subsequent chapters cover common molecular and neural abnormalities of cognitive impairments and mood deregulation, including topics such as neural atrophy, cholesterol, stress, and ageing. The book ends with current knowledge of convergence of antidementic and antidepressive pharmacology. The book is intended for scientists involved in the field, who may want a broader knowledge of all the aspects related to cognition and mood regulation, and for PhD or MD students, residents and neurologists who may wish to learn more about the interactions between cognition and mood. Neuropharmacologists will also benefit from the knowledge presented in the book in developing drugs that are more efficient to modify cognition and mood and more effective to restore normal cognitive and mood regulation.

The Role of Serotonin in Brain Development and 3,4-methylenedioxymethamphetamine-induced Cognitive Deficits

The Role of Serotonin in Brain Development and 3,4-methylenedioxymethamphetamine-induced Cognitive Deficits
Author : Tori Lynn Schaefer
Publisher : Unknown
Release Date : 2009
Category :
Total pages :239
GET BOOK

Serotonin (5-hydroxytryptamine, 5-HT) is thought to be important during brain development and is one of the first neurotransmitters to appear. It appears to act as a neurotrophic factor supporting the growth and maturation of both serotonergic and non-serotonergic cells during the pre and early postnatal periods prior to its role as a neurotransmitter. Disruption of 5-HT functioning during human development is thought to be associated with autism and schizophrenia. Early developmental exposure to stress or drugs of abuse disrupt 5-HT development and produces altered cognitive ability. To better understand the relationship between the developing serotonergic system and long-term cognitive function we employed the use of a genetic model in which 5-HT levels are depleted ~80% throughout life and the use of a model of 3,4-methylenedioxymethamphetamine (MDMA) exposure in which administration from postnatal day (P)11-20 is used; a period analogous to the second half of human gestation. Pet-1 is a transcription factor that is restricted in the brain to 5-HT neurons and has been shown to be important for their development and function. A loss of Pet-1 results in an 80% reduction of the number of 5-HT neurons as well as 5-HT tissue content. Pet-1 knockouts were tested as adults in both the Cincinnati and Morris water mazes that assess path integration and spatial learning, respectively. A reduction in cognitive ability was not observed in Pet-1 knockout mice, although they displayed decreased locomotor activity, increased marble burying, and increased startle reactivity. To better assess the role 5-HT plays during development for circuits involved in memory formation, we used a model of MDMA exposure that has previously been reported to produce protracted path integration and spatial learning deficits that last late into adulthood. In adults, MDMA produces an initial release of 5-HT followed by dramatic depletions, and these depletions can last for weeks. It was previously shown that neonatal MDMA administration on P11, the first day of the exposure period known to result in memory impairment (P11-20), also produced significant depletions in 5-HT. We further characterized the degree of 5-HT depletion that was experienced by rats exposed to P11 MDMA exposure and compared this to 5-HT reductions induced by other substituted amphetamines as well as determining the length and degree of depletion following P11-20 MDMA exposure. Substantial 5-HT depletions existed during all ten days of MDMA exposure, however, these depletions were not observed on P30. Citalopram (CIT), a highly selective SSRI, was used in combination with P11-20 MDMA exposure to attenuate the 5-HT depletions. Thereafter, cognitive ability was assessed in MDMA-treated animals with attenuated 5-HT depletions. The combination of CIT and MDMA did not improve learning ability; however CIT treatment alone produced deficits in path integration learning. These data suggest that 5-HT alterations during vulnerable critical periods can affect later cognitive ability, and they suggest that depletions in 5-HT alone may not account for cognitive dysfunction in neonatal rats treated with MDMA. Examination of specific 5-HT receptors is likely the next step to understand the mechanism involved in 5-HT disruption during development and later cognitive ability.

Critical Issues in the Treatment of Affective Disorders

Critical Issues in the Treatment of Affective Disorders
Author : Collegium Internationale Neuro-psychopharmacologicum. Workshop,Giorgio Racagni,S. Z. Langer
Publisher : S Karger Ag
Release Date : 1994
Category : Medical
Total pages :198
GET BOOK

The many ramifications of mood disorders, particularly depression, are the subject of this informative volume. Experts of international standing present their recent research on the causes, identification, prevalence and treatment of such problems. Geneticists, epidemiologists, psychiatrists and pharmacologists, as well as those working in clinical practice, will find much to interest them in the discussions of depression: its forms, therapy and connection with other affective disorders. Articles on nicotine and alcohol addiction, cancer, HIV, endocrine malfunction, geriatric ailments and pain indicate how frequently these are associated with depressive illnesses. The concept of comorbidity is seen as offering a fresh vantage point from which to take stock of complex situations and develop effective new ways of treatment.

International Journal of Neuroscience

International Journal of Neuroscience
Author : Anonim
Publisher : Unknown
Release Date : 1996
Category : Nervous system
Total pages :129
GET BOOK

Memory Dysfunctions

Memory Dysfunctions
Author : New York Academy of Sciences
Publisher : Unknown
Release Date : 1985
Category : Medical
Total pages :553
GET BOOK

Psychopharmacology

Psychopharmacology
Author : Herbert Y. Meltzer
Publisher : Raven Press (ID)
Release Date : 1987
Category : Medical
Total pages :1780
GET BOOK