January 15, 2021

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Theranostic Approach for Pancreatic Cancer

Theranostic Approach for Pancreatic Cancer
Author : Ganji Purnachandra Nagaraju,Sarfraz Ahmad
Publisher : Academic Press
Release Date : 2019-08-19
Category : Science
Total pages :410
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Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. The book discusses several topics related to pancreatic cancer, such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer“/li> Discusses treatment options available currently and prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment

Theranostics Approaches to Gastric and Colon Cancer

Theranostics Approaches to Gastric and Colon Cancer
Author : Ganji Seeta Rama Raju,L.V.K.S. Bhaskar
Publisher : Springer Nature
Release Date : 2020-03-04
Category : Medical
Total pages :250
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This book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to reverse the chemoresistance of tumors. In addition, the book explores the theranostic role of nanoparticles and therapeutic potential of phytochemicals with regard to colorectal cancer. Given its scope, the book offers a valuable guide for oncologists, academic researchers, pharmaceuticals practitioners, and students who are involved in research and treatment of cancer.

A Theranostic and Precision Medicine Approach for Female-Specific Cancers

A Theranostic and Precision Medicine Approach for Female-Specific Cancers
Author : Rama Rao Malla,Ganji Purnachandra Nagaraju
Publisher : Academic Press
Release Date : 2020-11-06
Category : Science
Total pages :318
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A Theranostic and Precision Medicine Approach for Female-Specific Cancers provides information regarding ongoing research and clinical data surrounding female specific cancers (breast, cervical, ovarian and endometrial cancers). The book encompasses detailed descriptions about diagnostics and therapeutic options for easy understanding, focusing on the subject matter with a broader range of treatment options. In addition, it explores new theranostics, i.e., diagnostic, therapeutic and precision medicine strategies currently being developed for FSCs. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of biomedical field who need to understand the most recent and promising approaches to manage FSCs. Explores new diagnostic biomarkers surrounding the early detection and prognosis of FSCs Examines new genetic and molecularly targeted approaches for the treatment of these aggressive diseases Discusses new theranostic approaches that combine diagnosis and treatment through the use of nanotechnology in FSCs Addresses how these various advances can be integrated into a precision and personalized medicine approach that can eventually enhance patient care

Core-Shell Nanostructures for Drug Delivery and Theranostics

Core-Shell Nanostructures for Drug Delivery and Theranostics
Author : Maria Focarete,Anna Tampieri
Publisher : Woodhead Publishing
Release Date : 2018-06-29
Category : Technology & Engineering
Total pages :466
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Core-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies and Prospects for Novel Carrier Systems contains valuable chapters that deal with the fundamentals of nanotechnology for drug delivery, recent developments and research in core-shell nanoparticles for drug-delivery and theranostic applications, and the potential and applications of core-shell nanofiber. This book is a highly valuable resource for scientists interested in the design and development of innovative drug delivery systems, researchers and graduate/postdoctoral students engaged in biomaterials for drug delivery, and R&D managers in the biomaterials and pharmaceutical industry. Focuses on core-shell nanoparticles and nanofiber for innovative applications, including cancer therapy, controlled release and multi-drug release Considers future prospects and potential new applications of core-shell nanostructures for drug delivery and theranostics Explains the principles and essential concepts of nanotechnology for drug delivery systems

Cancer Theranostics

Cancer Theranostics
Author : Xiaoyuan Chen,Stephen Wong
Publisher : Academic Press
Release Date : 2014-03-20
Category : Medical
Total pages :544
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Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives. Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapy Fully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management

Exploring Pancreatic Metabolism and Malignancy

Exploring Pancreatic Metabolism and Malignancy
Author : Ganji Purnachandra Nagaraju,Aramati BM Reddy
Publisher : Springer Nature
Release Date : 2019-11-23
Category : Medical
Total pages :268
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This book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery. Metabolic syndrome, which includes adnominal obesity, hypertension, dyslipidemia, and hyperglycemia, has recently been shown to play an important role in the etiology and progression of various cancers. Further, obesity and diabetes have been associated with an increased incidence of gastric cancers. The book reviews the key biological mechanisms underlying the association between metabolic dysregulation, including obesity-associated enhancement of growth factor signaling, inflammation, and perturbation in pancreatic cancer cell growth and metastasis. It also illustrates the role of the inflammatory signaling pathway in metabolic diseases as well as tumor growth and explores the potential of these pathways as the rational targets for pancreatic cancer therapy. Lastly, the book offers a comprehensive description of the challenges associated with diabetes and pancreatic cancer therapy.

Radiolabeled Moieties for Molecular Imaging and Cancer Theranostics

Radiolabeled Moieties for Molecular Imaging and Cancer Theranostics
Author : Carolina de Aguiar Ferreira
Publisher : Unknown
Release Date : 2019
Category :
Total pages :112
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Nuclear medicine, including the use of radioactive materials for imaging and therapy, has its role well estabilished. For nuclear medicine applications, not only the choice of radioisotope with characteristics that matchs the application purpose, but also the isotope "carrier" needs to be taken into account, as it "controls" the radiotracer biodistribution and other important biological interactions. Noteworthy, these "carriers" can be of any type, such as nanomaterial or antibodybased. Since nuclear medicine can be as multidisciplinary as the biomedical engineering field, herein, I have chosen to explore both routes of achieving molecular imaging and cancer theranostics: using nanoparticle and antibody-based probes. In chapter 2, we have demonstrated the synthesis of size-optimized ultrasmall porous silica nanoparticles (UPSN), with improved pharmacokinetics, i.e. prolonged blood circulation half-life and reasonably fast systemic clearance. We have systematically investigated the influence of vascular architecture and stromal microenvironment on the accumulation and retention of as-designed UPSN in two different triplenegative breast cancer models. After successfully determining that UPSN can highly accumulate in tumor tissues through EPR effect, we decided, in chapter 3, to evaluate if the same nanoparticles could act as a nanocarrier of a theranostic isotopic pair 86/90Y. In that chapter, we demonstrated that the nanoparticles, when radiolabeled with 86Y, were selectively taken up by tumors cells and were clearly visualized through PET imaging at all time points investigated. 90YDOTA-UPSN provided promising therapeutic results by significantly reducing tumor volumes when compared to all the other groups investigated and by significantly increasing average survival. In chapter 4, we have employed a theranostic approach using the isotopic pair 86Y/90Y targeting tissue factor in a pancreatic cancer model through the use of ALT836 monoclonal antibody. We demonstrated that the anti-TF monoclonal antibody, when radiolabeled with 86Y, allowed PET imaging of pancreatic cancer tumor tissue with excellent tumor contrast and could allow for dosimetric calculation of potential dose that would be received with its isotopic pair 90Y. When radiolabeled with 90Y, ALT836 provided evidence of anti-tumor effects and increased average survival. We have evaluated and characterized the ability of 52Mn-labeled YY146, a specific antibody targeting human CD146 to act as a CD146-specific breast tumor imaging agent, with capability of delineating different CD146 expressions. PET imaging, for up to 7 days, of mice bearing three different breast tumors were carried out and revealed radiotracer uptake in tumors that strongly (r2=0.98, p

Hybrid Nanostructures for Cancer Theranostics

Hybrid Nanostructures for Cancer Theranostics
Author : Raghvendra Ashok Bohara,Nanasaheb D. Thorat
Publisher : Elsevier
Release Date : 2018-11-19
Category : Science
Total pages :276
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Hybrid nanostructures are nanoparticles which incorporate two or more structures. These structures may represent organic or inorganic material, but they synergistically improve the application of the material for end users. Hybrid Nanostructures for Cancer Theranostics explores how hybrid nanostructures are used in cancer treatment. Focusing on the properties of hybrid nanostructures, the book demonstrates how their unique characteristics can be used to create more effective treatment techniques. In the second half of the book, the chapters examine how hybrid nanostructures are currently being used in practice, assessing the pros and cons of using different types of nanostructures for different treatments. This valuable resource will allow readers to understand the core and emerging concept of functionalization, bioconjugation, hyperthermia and phototherapy of nanoparticles which allows for the greater use of hybrid nanomaterials in cancer theranostics. Shows how the use of novel hybrid nanostructures can lead to more effective cancer treatments. Explores how hybrid nanostructures are used for different treatment types, including photo thermal therapy and drug delivery. Explains how the use of hybrid nanostructures can lead to more rapid cancer diagnosis.

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy

Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy
Author : Ganji Purnachandra Nagaraju
Publisher : Academic Press
Release Date : 2019-02-26
Category : Science
Total pages :223
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Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it

Antineoplastics—Advances in Research and Application: 2013 Edition

Antineoplastics—Advances in Research and Application: 2013 Edition
Author : Anonim
Publisher : ScholarlyEditions
Release Date : 2013-06-21
Category : Medical
Total pages :161
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Antineoplastics—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Antibiotics - Antineoplastics. The editors have built Antineoplastics—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Antibiotics - Antineoplastics in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Antineoplastics—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Novel Nanomaterials

Novel Nanomaterials
Author : George Kyzas,Athanasios C. Mitropoulos
Publisher : BoD – Books on Demand
Release Date : 2018-04-18
Category : Technology & Engineering
Total pages :370
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"Nanomaterials" is a special topic of recent research and is a milestone of nanoscience and nanotechnology. Nanoscale materials are a series of substances/compounds, in which at least one dimension has smaller size than 100 nm. Nanomaterials have a broad area of development, which is growing rapidly day by day. Their impact on commercial applications as well as on the respective academia and education is huge. The basic points of this book can be divided into synthesis of nanomaterials and their applications. For example, special mention is about metal-oxide nanostructures, nanocomposites, and polymeric nanomaterials. Also, synthesis, characterizations, various processes, fabrications and some promising applications are also developed and analyzed.

Role of Transcription Factors in Gastrointestinal Malignancies

Role of Transcription Factors in Gastrointestinal Malignancies
Author : Ganji Purnachandra Nagaraju,Pallaval Veera Bramhachari
Publisher : Springer
Release Date : 2018-03-27
Category : Medical
Total pages :513
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This book illustrates the importance of transcription factors in gastrointestinal cancer progression and metastasis with regard to understanding the mechanism and target definition in drug discovery. Further, it describes the complex issues associated with cancer cell growth and metastasis. The respective chapters provide detailed information on the various types of transcription factors (NF-kB, HIF-1, STAT-3, E2F1, and Sp1) and gastric-associated cancers (esophagus, stomach, colorectal, liver and pancreatic cancers) in connection with specific functional studies like cell cycle, angiogenesis, migration, invasion and apoptosis. These transcription factors control the expression of several signaling pathways involved in tumor growth, making them ideal targets for gastrointestinal cancer therapy. In closing, the book provides comprehensive descriptions of the major challenges associated with gastrointestinal cancer therapy.

Diagnostic Immunohistochemistry

Diagnostic Immunohistochemistry
Author : David J. Dabbs
Publisher : Unknown
Release Date : 2018
Category : Medical
Total pages :944
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User-friendly and concise, the new edition of this popular reference is your #1 guide for the appropriate use of immunohistochemical stains. Dr. David J. Dabbs and leading experts in the field use a consistent, organ system approach to cover all aspects of the field, with an emphasis on the role of genomics in diagnosis and theranostic applications that will better inform treatment options. Each well-written and well-researched chapter is enhanced with diagnostic algorithms, charts, tables, and superb, full-color histologic images, making this text a practical daily resource for all surgical pathologists. Features a systematic approach to the diagnostic entities of each organ system, including detailed differential diagnoses, diagnostic algorithms, and immunohistograms that depict immunostaining patterns of tumors. Covers many more antigens than other texts, and discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Contains new material on non-lymphoid malignancies, Hodgkin/non-Hodgkin lymphoma, and an expanded chapter on digital imaging and quantitative immunohistochemistry. Provides new grading schemes for several organs, along with new antibodies to cover more genomic immunohistochemistry applications. Offers more emphasis in the breast section of "eyes on" tissue for molecular/IHC prognostics compared to the current trend of gene-expression profiling of breast cancer. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Role of Tyrosine Kinases in Gastrointestinal Malignancies

Role of Tyrosine Kinases in Gastrointestinal Malignancies
Author : Ganji Purnachandra Nagaraju
Publisher : Springer
Release Date : 2018-09-27
Category : Medical
Total pages :241
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The aim of this book is to provide comprehensive overview of the role of different tyrosine kinases in the progression and metastasis of various cancers of the gastrointestinal tract such as esophagus, liver, pancreas, stomach, and colorectal. Activation of various signaling pathways and tyrosine kinases are responsible for resistance to chemo and radiotherapy in these gastrointestinal malignancies. Targeting these tyrosine kinases, which regulate the activities of survival pathways in growth, and metastasis is a rational strategy in gastrointestinal cancer therapy. Each chapter embedded in this book covers information pertaining to a specific tyrosine kinase and its impact on various malignancies, which is not only significant for basic and clinical research investigations but will also be valued by students at advanced undergraduate to postgraduate levels.

Nanotheranostics for Cancer Applications

Nanotheranostics for Cancer Applications
Author : Prakash Rai,Stephanie A. Morris
Publisher : Springer
Release Date : 2018-11-12
Category : Technology & Engineering
Total pages :480
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This book is the first to focus specifically on cancer nanotheranostics. Each of the chapters that make up this comprehensive volume is authored by a researcher, clinician, or regulatory agency member known for their expertise in this field. Theranostics, the technology to simultaneously diagnose and treat a disease, is a nascent field that is growing rapidly in this era of personalized medicine. As the need for cost-effective disease diagnosis grows, drug delivery systems that can act as multifunctional carriers for imaging contrast and therapy agents could provide unique breakthroughs in oncology. Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response and initiate secondary treatments if required. In oncology, chemotherapeutics have been routinely used. Some drugs have proven effective but all carry risks of adverse side effects. There is growing interest in using remotely triggered drug delivery systems to limit cytotoxicity in the diseased area. This book reviews the use of theranostic nanoparticles for cancer applications over the past decade. First, it briefly discusses the challenges and limitations of conventional cancer treatments, and presents an overview of the use of nanotechnology in treating cancer. These introductory chapters are followed by those exploring cancer diagnosis and a myriad of delivery methods for nanotherapeutics. The book also addresses multifunctional platforms, treatment monitoring, and regulatory considerations. As a whole, the book aims to briefly summarize the development and clinical potential of various nanotheranostics for cancer applications, and to delineate the challenges that must be overcome for successful clinical development and implementation of such cancer theranostics.