November 27, 2020

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Methods of Therapeutic Drug Monitoring Including Pharmacogenetics

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics
Author : Georg Hempel
Publisher : Elsevier
Release Date : 2019-10-17
Category : Science
Total pages :380
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Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Therapeutic Drug Monitoring

Therapeutic Drug Monitoring
Author : Amitava Dasgupta
Publisher : Academic Press
Release Date : 2012
Category : Medical
Total pages :459
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Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring. Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants. Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques.

Clinical Challenges in Therapeutic Drug Monitoring

Clinical Challenges in Therapeutic Drug Monitoring
Author : William Clarke,Amitava Dasgupta
Publisher : Elsevier
Release Date : 2016-07-21
Category : Medical
Total pages :376
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Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography

Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography
Author : Steven H.Y. Wong
Publisher : CRC Press
Release Date : 1985-02-01
Category : Medical
Total pages :512
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This important, new reference provides the first , up-to-date, and comprehensive treatmentof the various liquid chromatography (LC) instrumentation for Therapeutic DrugMonitoring (TDM) and toxicology drug assays and reviews the clinical pharmacologyof major classes of drugs and their LC analyses.Written by authoritative contributors who bring many years of personal laboratory/clinical experience to the book, this interdisciplinary work : presents the principlesof TDM, sampling techniques, and various instrumentation topics, including computerinterfacing, mass spectrometry, fluorescence , electrochemical detection, and bloodcollection devices . .. examines six primary classes of drugs, complete with recommendedLC procedures and emphasizing recently introduced drugs and their LC analyses. .. and documents medicolegal guidelines and laboratory management considerations,providing a contemporary assessment of today's laboratory needs.The only practical, current guide available on the subject, Therapeutic Drug Monitoringand Toxicology by Li([uid Chromatography belongs in the personal libraries of clinicaland analytical chemists and biochemists, clinical pharmacologists, clinical toxicologists,clinical pathologists, immunologists, liquid chromatographers, mass spectroscopists, laboratorydirectors, laboratory instrument manufacturers , and medical technologists. Thebook is also vital supplementary reading for advanced undergraduate and graduate-levelclinical chemistry, toxicology, clinical pathology, and liquid chromatography course.

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring

Advances in Chromatographic Techniques for Therapeutic Drug Monitoring
Author : Amitava Dasgupta
Publisher : CRC Press
Release Date : 2009-10-06
Category : Medical
Total pages :475
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For drugs with a narrow therapeutic index, therapeutic drug monitoring methods are essential for patient management. Although immunoassays are commercially available for many drugs and most laboratories use these assays for routine therapeutic monitoring, they have many limitations which hinder their efficacy. Providing practical guidelines for imp

Therapeutic Drug Monitoring Data

Therapeutic Drug Monitoring Data
Author : Amitava Dasgupta,Matthew Krasowski
Publisher : Academic Press
Release Date : 2019-09-14
Category : Science
Total pages :382
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Therapeutic Drug Monitoring Data: A Concise Guide, Fourth Edition serves as a ready resource of information on commonly monitored drugs that will help readers make decisions relating to the monitoring and interpretation of results. It is an easy-to-read source of information on intended use, pharmacokinetics, therapeutic range, and toxic concentrations, as well as bioavailability, disposition, metabolism and the excretion of commonly monitored therapeutic drugs. This fully updated fourth edition includes sections on new anticonvulsants, anti-depressant and anti-HIV drugs, new drugs for advanced cancer treatment, and thoroughly updated chapters that address new pitfalls and problems in the lab. Serves as a ready resource of information for commonly monitored drugs Presents a useful, quick guide for those making decisions related to monitoring and interpretation of results Provides concise, easily digestible content for clinical laboratory scientists, toxicologists and clinicians

Therapeutic Drug Monitoring

Therapeutic Drug Monitoring
Author : Gerald E. Schumacher
Publisher : McGraw-Hill/Appleton & Lange
Release Date : 1995
Category : Medical
Total pages :684
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Essentials of Therapeutic Drug Monitoring

Essentials of Therapeutic Drug Monitoring
Author : Benjamin Gerson
Publisher : Igaku-Shoin Medical Publishers
Release Date : 1983
Category : Medical
Total pages :463
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Handbook of Analytical Therapeutic Drug Monitoring and Toxicology

Handbook of Analytical Therapeutic Drug Monitoring and Toxicology
Author : Steven H.Y. Wong,Irving Sunshine
Publisher : CRC Press
Release Date : 1996-12-20
Category : Medical
Total pages :368
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Adapting modern advances in analytical techniques to daily laboratory practices challenges many toxicologists, clinical laboratories, and pharmaceutical scientists. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you keep abreast of the innovative changes that can make your laboratory - and the studies undertaken in it - a success. This volume simplifies your search for appropriate techniques, describes recent contributions from leading investigators, and provides valuable evaluations and advice. Discover how to use non-invasively obtained specimens to your best advantage The text features alternative biological specimens such as hair, meconium, saliva, sweat, and vitreous humor, which are not extensively used because they require more sensitive procedures than other biological specimens. How to overcome these limitations is a major topic of the handbook. Experts describe basic principles of innovative techniques and detail how they can be adapted to analyzing alternative biological specimens. The evaluations of the pros and cons of various advances in immunodiagnostics and how they apply to analytes will help you determine their suitability to your own laboratory. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you make the most of innovative procedures that will open the doors to productive laboratory practices.

Applied Pharmacokinetics

Applied Pharmacokinetics
Author : William E. Evans,Jerome J. Schentag,William J. Jusko
Publisher : Applied Therapeutics, Incorporated
Release Date : 1992
Category : Medical
Total pages :1202
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The Third Edition of Applied Pharmacokinetics remains the gold standard by which all other clinical pharmacokinetics texts are measured. Written by leading pharmacokinetics researchers and practitioners, this book is the most advanced kinetics reference available. All chapters have been extensively updated or completely rewritten for this edition, and six new chapters have been added on pharmacodynamics, pharmacogenetics, pharmacokinetic considerations in the obese, dietary influences on drug disposition, zidovudine, and corticosteroids. Each chapter is tightly focused on the most important concepts and issues. Chapters on specific drugs are organized in a consistent format for quick, easy information retrieval. Major subheadings include Clinical Pharmacokinetics, Pharmacodynamics, Clinical Application of Pharmacokinetic Data, Analytical Methods, and Prospectus.

A Textbook for the Clinical Application of Therapeutic Drug Monitoring

A Textbook for the Clinical Application of Therapeutic Drug Monitoring
Author : William James Taylor,Mary H. Diers Caviness
Publisher : Abbott Laboratories Diagnostics Division
Release Date : 1986
Category : Drug monitoring
Total pages :487
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Applied Pharmacokinetics & Pharmacodynamics

Applied Pharmacokinetics & Pharmacodynamics
Author : Michael E. Burton
Publisher : Lippincott Williams & Wilkins
Release Date : 2006
Category : Medical
Total pages :867
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The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy. This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.

Therapeutic Drug Monitoring and Clinical Biochemistry

Therapeutic Drug Monitoring and Clinical Biochemistry
Author : Mike Hallworth,Nigel Capps
Publisher : Amer Assn for Clinical Chemistry
Release Date : 1993
Category : Science
Total pages :178
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This text considers the close inter-relationship of therapeutic drug monitoring and clinical biochemistry. It covers principles of TDM, looking at drug dosage and effect; clinical monitoring and pharmacokinetics; interpretation and response; and near-patient testing. It also includes information on methodology, dosage prediction, drug structure, sampling requirements and target range. The drugs covered include anti-convulsants; aminoglycosides; lithium; anti-arrythmics; xanthines; cyclosporine; methotrexate; and tricyclics. The work also contains case studies.

Interpretations in Therapeutic Drug Monitoring

Interpretations in Therapeutic Drug Monitoring
Author : Daniel M. Baer,William R. Dito
Publisher : Amer Society of Clinical
Release Date : 1981
Category : Medical
Total pages :388
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Applied Therapeutic Drug Monitoring: Fundamentals

Applied Therapeutic Drug Monitoring: Fundamentals
Author : Thomas P. Moyer,Roger L. Boeckx
Publisher : AACC Press
Release Date : 1982
Category : Body fluids
Total pages :239
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