June 12, 2021

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Studies on Early Immune Responses to Toxoplasma Gondii

Studies on Early Immune Responses to Toxoplasma Gondii
Author : L. Cristina Gavrilescu
Publisher : Unknown
Release Date : 2003
Category :
Total pages :264
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In sum, these studies show that death during Toxoplasma infection may be the result of either excessive type 1 cytokine response, or inadequate Th1 differentiation and effector function. My work shows that this outcome depends on both parasite and host genetic background.

Toxoplasma gondii

Toxoplasma gondii
Author : Uwe Gross
Publisher : Springer
Release Date : 2012-11-10
Category : Medical
Total pages :276
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For years, toxoplasmosis has been known as disease mostly affecting newborns. Since immunocompromised patients (AIDS) present a high risk of reactivation of chronic toxoplasmosis this parasitic disease has gained increasing interest. Besides presenting clinical and therapeutical concepts, this volume provides current knowledge about genetics and immunology of T. gondii and the interaction with its 'host'. Since in vivo and in vitro models of toxoplasmosis exist, and genetic manipulation has become possible, this protozoan parasite has recently been accepted as a model for understanding the pathogenesis and persistance of other intracellular parasites. The articles of the book compromise both reviewing current concepts and reporting on yet unpublished results of leading scientists in this field.

Waterborne Transmission of Toxoplasma Gondii

Waterborne Transmission of Toxoplasma Gondii
Author : Karen Shapiro
Publisher : Unknown
Release Date : 2009
Category :
Total pages :286
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The Role of Inflammatory Cytokines in Immune Responses to Toxoplasma Gondii

The Role of Inflammatory Cytokines in Immune Responses to Toxoplasma Gondii
Author : Anthony Joseph Marshall
Publisher : Unknown
Release Date : 1998
Category :
Total pages :194
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Toxoplasma Gondii

Toxoplasma Gondii
Author : Louis M. Weiss,Kami Kim
Publisher : Elsevier
Release Date : 2011-04-28
Category : Science
Total pages :800
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Toxoplasmosis is caused by a one-celled protozoan parasite known as Toxoplasma gondii. In the United States, it is estimated that approximately 30% of cats, the primary carriers, have been infected by T. gondii. Most humans contract toxoplasmosis by eating cyst-contaminated raw or undercooked meat, vegetables, or milk products or when they come into contact with the T. gondii eggs from cat feaces while cleaning a cat's litterbox, gardening, or playing in a sandbox. Approx 1 in 4 (more than 60 million) people in the USA are infected with the parasite, and in the UK between 0.5 and 1% of individuals become infected each year. By the age of 50, 40% of people test positive for the parasite. The predilection of this parasite is for the central nervous system (CNS) causing behavioral and personality alterations as well as fatal necrotizing encephalitis, and is especially dangerous for HIV infected patients. Though there have been tremendous strides in our understanding of the biology of Toxoplasma gondii in the last decade, there has been no systemic review of all of the information that has accumulated. Toxoplasma gondii provides the first comprehensive summary of literature on this organism by leading experts in the field who were responsible for organising the 7th International Congress on Toxoplasmosis in May 2003. It offeres systematic reviews of the biology of this pathogen as well as descriptions of the methods and resources used. Within the next year the T. gondii genome will be completed making this an indispensable research resource for biologists, physicians, parasitologists, and for all those contemplating experiments using T. gondii. * Serves as a model for understanding invasion of host cells by parasites, immune response, motility, differentiation, phylogenetics, evolution and organelle acquisition * Discusses the protocols related to genetic manipulation, cell biology and animal models while also providing reference material on available resources for working with this organism

The epidemiology of Toxoplasma gondii in cats and rodents from the Morro Bay area, California

The epidemiology of Toxoplasma gondii in cats and rodents from the Morro Bay area, California
Author : Haydee Ann Dabritz
Publisher : Unknown
Release Date : 2006
Category :
Total pages :378
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Toxoplasma gondii

Toxoplasma gondii
Author : Uwe Gross
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Medical
Total pages :276
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For years, toxoplasmosis has been known as disease mostly affecting newborns. Since immunocompromised patients (AIDS) present a high risk of reactivation of chronic toxoplasmosis this parasitic disease has gained increasing interest. Besides presenting clinical and therapeutical concepts, this volume provides current knowledge about genetics and immunology of T. gondii and the interaction with its 'host'. Since in vivo and in vitro models of toxoplasmosis exist, and genetic manipulation has become possible, this protozoan parasite has recently been accepted as a model for understanding the pathogenesis and persistance of other intracellular parasites. The articles of the book compromise both reviewing current concepts and reporting on yet unpublished results of leading scientists in this field.

Microbiology Abstracts

Microbiology Abstracts
Author : Anonim
Publisher : Unknown
Release Date : 1993
Category : Algology
Total pages :129
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A Bibliography of Toxoplasmosis and Toxoplasma Gondii

A Bibliography of Toxoplasmosis and Toxoplasma Gondii
Author : Don Edgar Eyles,Jacob Karl Frenkel
Publisher : Unknown
Release Date : 1952
Category : Toxoplasmosis
Total pages :47
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Toxoplasma Gondii Host Interactions: A Story of Immune Attack and Parasite Counterattack

Toxoplasma Gondii Host Interactions: A Story of Immune Attack and Parasite Counterattack
Author : Jeroen P. J. Saeij,Eva Frickel,Kirk Jensen,Nicolas Blanchard
Publisher : Frontiers Media SA
Release Date : 2020-08-10
Category :
Total pages :129
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Toxoplasma gondii is an obligate intracellular parasite that can infect all warm-blooded animals, including an estimated ~30% of humans. It can cause severe disease in immune-suppressed individuals and in fetuses as well as blinding chorioretinitis in adults and children. Toxoplasma-innate immune system interactions determine early parasite control and activation of the adaptive immune system by the host and are therefore critical in determining host survival during the acute phase of infection. However, induction of an exaggerated inflammatory response can also lead to pathology. Only the chronic tissue cyst form of Toxoplasma is orally infectious. It is therefore critical for the parasite’s survival during the chronic phase to escape immune responses at this stage as well. Toxoplasma exists as genetically divergent strains mostly depending on geography, with the most strain diversity being found in South America. The key to Toxoplasma’s successful co-option of the host are proteins secreted from its rhoptry and dense granule secretory organelles. Rhoptry proteins (ROPs) are secreted into the host cell cytoplasm upon invasion while dense granule proteins (GRAs) are secreted once the parasite establishes itself in its parasitophorous vacuole (PV). GRAs can localize to the PV, the PV membrane, or are secreted beyond the PVM into the host cytoplasm. Many ROPs and GRAs are involved in modulating host cell signaling pathways and evasion of host immune responses and play important roles in Toxoplasma virulence. Polymorphisms in Toxoplasma’s ROPs and GRAs, likely determine how well these effectors bind to the divergent substrates in different host species, which can explain Toxoplasma strain differences in virulence in a particular host species. By studying Toxoplasma we have not only started to unravel how the parasite modulates immune responses to enhance its survival, replication, and transmission but we have also learned a lot about the immune system. Many unique mechanisms of immunity have indeed been defined using Toxoplasma and this parasite has aided our understanding of tissue-specific immune responses in the brain and intestine. This Research Topic will give a comprehensive overview of Toxoplasma-host immune response interactions. Most Toxoplasma virulence determinants to date have been established in murine systems and it is unclear how the parasite interacts with other intermediate hosts and humans. In addition, the interactions of Toxoplasma with some of the most relevant cell types during infection, including dendritic cells, neurons, intestinal epithelial cells or vascular endothelial cells, remain poorly understood.

Toxoplasma gondii

Toxoplasma gondii
Author : Christopher J. Tonkin
Publisher : Humana
Release Date : 2020-11-23
Category : Medical
Total pages :470
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This volume covers a diverse collection of protocols currently being used by the Toxoplasma research community, and also looks at innovative methods that are pushing the boundaries of possibilities. Chapters in this book discuss topics such as isolation and genotyping of Toxoplasma gondii strains; assessing rhoptry secretion in T. gondii; plate-based quantification of stimulated Toxoplasma egress; methods to study ocular toxoplasmosis; and metabolic analysis of Toxoplasma gondii tachyzoites. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Toxoplasma gondii: Methods and Protocols is a valuable resource for students or groups starting off in the field, as well as laboratories interested in implementing the latest techniques described in the book.

Chemical Abstracts

Chemical Abstracts
Author : Anonim
Publisher : Unknown
Release Date : 2002
Category : Chemistry
Total pages :129
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Infectious Diseases of the Fetus and Newborn Infant

Infectious Diseases of the Fetus and Newborn Infant
Author : Jack S. Remington,Jerome O. Klein
Publisher : W.B. Saunders Company
Release Date : 1976
Category : Communicable diseases
Total pages :1121
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Human Toxoplasmosis

Human Toxoplasmosis
Author : Darrel O. Ho-yen,Alex W. L. Joss
Publisher : Unknown
Release Date : 1992
Category : Law
Total pages :265
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Toxoplasmosis, a world-wide infection of animals and humans, may produce severe congenital abnormalities in pregnancy, while among the immunocompromised (malignancies, organ transplant, or human immunodeficiency virus infection), death may result. Toxoplasmosis is likely to become more common, and those who manage high-risk patients must be aware of the infection, and the latest techniques for minimizing its serious complications. Women need testing consistent with medical defence advice as well as advice on avoiding infection. This comprehensive volume contains chapters on the history of toxoplasmosis, its clinical features and life cycle, diagnosis management, prevention, and possible future developments. Animal infection, with its important economic and human implications, is considered separately. The appendix contains a detailed treatment of common questions that arise in pregnancy, which will help practitioners explain the condition to their patients. This important book will be of value to medical practitioners and other professionals dealing with toxoplasmosis.

The Journal of Infectious Diseases

The Journal of Infectious Diseases
Author : Anonim
Publisher : Unknown
Release Date : 1995-04
Category :
Total pages :129
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