November 24, 2020

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Transition Metal-Catalyzed Pyridine Synthesis

Transition Metal-Catalyzed Pyridine Synthesis
Author : Xiao-Feng Wu
Publisher : Elsevier
Release Date : 2016-02-07
Category : Science
Total pages :90
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Transition Metal-Catalyzed Pyridine Synthesis provides an overview of pyridines, describing properties of these heterocycle compounds and describing traditional synthetic procedures for them. The book then explores catalyzed procedures for pyridine synthesis in greater detail and depth than is currently available in published Review articles. The short series Transition Metal-Catalyzed Heterocycles Synthesis, authored by Xiao-Feng Wu, summarizes recent achievements on heterocycles synthesis with transition metal as the catalysts, with each volume dedicated to one heterocycle compound. Brief, focused review of this active research area, Pyridine synthesis via transition metal catalysis Useful coverage of Pyridine properties and both intermolecular and intramolecular cyclization Volume Two in Elsevier’s short work series, "Transition Metal-Catalyzed Heterocycles Synthesis"

Transition Metal-Catalyzed Heterocycle Synthesis Via C-H Activation

Transition Metal-Catalyzed Heterocycle Synthesis Via C-H Activation
Author : Xiao-Feng Wu
Publisher : John Wiley & Sons
Release Date : 2016-03-07
Category : Science
Total pages :600
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Reflecting the tremendous growth of this hot topic in recent years, this book covers C-H activation with a focus on heterocycle synthesis. As such, the text provides general mechanistic aspects and gives a comprehensive overview of catalytic reactions in the presence of palladium, rhodium, ruthenium, copper, iron, cobalt, and iridium. The chapters are organized according to the transition metal used and sub-divided by type of heterocycle formed to enable quick access to the synthetic route needed. Chapters on carbonylative synthesis of heterocycles and the application of C-H activation methodology to the synthesis of natural products are also included. Written by an outstanding team of authors, this is a valuable reference for researchers in academia and industry working in the field of organic synthesis, catalysis, natural product synthesis, pharmaceutical chemistry, and crop protection.

Heterocyclic Chemistry in Drug Discovery

Heterocyclic Chemistry in Drug Discovery
Author : Jie Jack Li
Publisher : John Wiley & Sons
Release Date : 2013-04-26
Category : Science
Total pages :720
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Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Aspects of Homogeneous Catalysis

Aspects of Homogeneous Catalysis
Author : R. Ugo
Publisher : Springer Science & Business Media
Release Date : 2012-12-06
Category : Science
Total pages :356
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1. INTRODUCTION Although quite spectacular results have been obtained in the last few decades in the field of homogeneous transition metal catalyzed transformations of olefins and alkynes [1], reactions which could lead to heterocycles have been partly neglected. An obvious reason for this is that substrates containing heteroatoms such as N, 0 or S could coordinate the metal and suppress the catalytic activity. Nevertheless, some interesting early examples of transition-metal-catalyzed syntheses of heterocyclic compounds have been reported and these have been reviewed by C. W. Bird [2] . More recently the incorporation of CO , which enables esters and lactones 2 to be synthesized from olefinic starting materials, has begun to attract attention (see, for example, ref. [3]). The dominant role of palladium as the catalyst for the formation of O-containing heterocycles has been suggested to be associated with the relatively low strength of the Pd-O bond. Among the first examples of a nitrogen-containing heterocycle to be formed by homogeneous catalysis is the triazine shown in Equation 1 which is the product of the trimerization of benzonitrile in the presence of iron penta carbonyl or Raney nickel [4] .

Transition Metals for Organic Synthesis

Transition Metals for Organic Synthesis
Author : Matthias Beller,Carsten Bolm
Publisher : Wiley-VCH
Release Date : 1998-09-17
Category : Science
Total pages :1120
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This two volume set presents contemporary research and application in the economically and scientifically important area of transition metals for organic synthesis and fine chemicals production.

Progress in Heterocyclic Chemistry

Progress in Heterocyclic Chemistry
Author : Gordon W. Gribble,J. Joule
Publisher : Elsevier
Release Date : 2009-09-03
Category : Science
Total pages :572
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Progress in Heterocyclic Chemistry (PHC) is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year’s literature on heterocyclic chemistry and articles on emerging topics of particular interest to heterocyclic chemists. The chapters in Volume 21 constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2008. Additional articles in this volume review "Biocatalytic approaches to chiral heterocycles" and "Ring-expanded (‘fat’) purines and their nucleoside/nucleotide analogues as broad-spectrum therapeutics." As with previous volumes in the series, Volume 21 apprises academic/industrial chemists and advanced students of developments in heterocyclic chemistry in a convenient format. * Covers the heterocyclic literature published in 2008 * Includes specialized reviews * Features contributions from leading researchers in their fields

The Design and Development of New Transition Metal-catalyzed Serial and Multi-component Cycloadditions

The Design and Development of New Transition Metal-catalyzed Serial and Multi-component Cycloadditions
Author : Gabriel Grant Gamber
Publisher : Unknown
Release Date : 2004
Category :
Total pages :470
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Applications of Transition Metal Catalysis in Drug Discovery and Development

Applications of Transition Metal Catalysis in Drug Discovery and Development
Author : Matthew L. Crawley,Barry M. Trost
Publisher : John Wiley & Sons
Release Date : 2012-05-14
Category : Science
Total pages :376
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This book focuses on the drug discovery and developmentapplications of transition metal catalyzed processes, which canefficiently create preclinical and clinical drug candidates as wellas marketed drugs. The authors pay particular attention tothe challenges of transitioning academically-developed reactionsinto scalable industrial processes. Additionally, the book lays thegroundwork for how continued development of transition metalcatalyzed processes can deliver new drug candidates. This workprovides a unique perspective on the applications of transitionmetal catalysis in drug discovery and development – it is aguide, a historical prospective, a practical compendium, and asource of future direction for the field.

Development of Transition Metal-catalyzed Methods for the Enantioselective Synthesis of P-stereogenic Phosphines

Development of Transition Metal-catalyzed Methods for the Enantioselective Synthesis of P-stereogenic Phosphines
Author : Vincent Sai Ho Chan
Publisher : Unknown
Release Date : 2008
Category :
Total pages :580
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Index Volume Category 3

Index Volume Category 3
Author : C J Drayton,Jutta Backes
Publisher : Georg Thieme Verlag
Release Date : 2013-12-11
Category : Science
Total pages :1000
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Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to date for the entire field of organic and organometallic chemistry. As the only resource providing full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, Science of Synthesis is therefore a unique chemical information tool. Over 1000 world-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. The systematic, logical and consistent organization of the synthetic methods for each functional group enables users to quickly find out which methods are useful for a particular synthesis and which are not. Effective and practical experimental procedures can be implemented quickly and easily in the lab.//The content of this e-book was originally published in May 2008.

Transition Metal Catalysis in Aerobic Alcohol Oxidation

Transition Metal Catalysis in Aerobic Alcohol Oxidation
Author : Francesca Cardona,Camilla Parmeggiani
Publisher : Royal Society of Chemistry
Release Date : 2014-10-21
Category : Science
Total pages :280
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The oxidation of primary and secondary alcohols to the corresponding carbonyl compounds is of fundamental importance in organic synthesis, due to the wide use of these products as precursors and intermediates for many drugs, vitamins and fragrances. However, traditional oxidants are often toxic and release considerable amounts of by-products. As an alternative, oxygen is among the cheaper and less polluting stoichiometric oxidants, and the implementation of a transition metal-based catalyst in combination with oxygen represents an emerging alternative to the traditional procedures. This book aims to give an overview of the aerobic oxidation of alcohols catalyzed by transition metals, and covers the most important advances in the last fifteen years. Following an introductory chapter on homogeneous-, heterogeneous- and nano-catalysis, use of copper, ruthenium, palladium, gold, vanadium and iron are discussed in turn. The book concludes with a useful overview that includes representative experimental procedures. This book will provide a valuable reference to organic chemists and green chemists in academia and industry.

Transition Metal Catalyzed Carbonylation Reactions

Transition Metal Catalyzed Carbonylation Reactions
Author : Matthias Beller,Xiao-Feng Wu
Publisher : Springer Science & Business Media
Release Date : 2013-08-13
Category : Science
Total pages :228
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Transition Metal Catalyzed Carbonylation Reactions is a comprehensive monograph focusing on carbon monoxide usage. This book provides students and researchers in organic synthesis with a detailed discussion of carbonylation from the basics through to applications. The authors have structured the book around the types of reactions, based on the different nucleophiles involved. Scientists working in carbonylation or with carbon monoxide, as well as teachers of organic synthesis can use this book to become familiar with this important area of organic chemistry.

Progress in Inorganic Chemistry

Progress in Inorganic Chemistry
Author : Kenneth D. Karlin
Publisher : John Wiley & Sons
Release Date : 2014-07-22
Category : Science
Total pages :592
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This series provides inorganic chemists and materials scientistswith a forum for critical, authoritative evaluations of advances inevery area of the discipline. Volume 59 continues to report recentadvances with a significant, up-to-date selection of contributionsby internationally-recognized researchers. The chapters of this volume are devoted to the followingtopics: • Iron Catalysis in Synthetic Chemistry • A New Paradigm for Photodynamic Therapy Drug Design:Multifunctional, Supramolecular DNA Photomodification AgentsFeaturing Ru(II)/Os(II) Light Absorbers Coupled to Pt(II) orRh(III) Bioactive Sites • Selective Binding of Zn2+ Complexes to Non-CanonicalThymine or Uracil in DNA or RNA. • Progress Toward the Electrocatalytic Production ofLiquid Fuels from Carbon Dioxide • Monomeric Dinitrosyl Iron Complexes: Synthesis andReactivity • Interactions of Nitrosoalkanes/arenes, Nitrosamines,Nitrosothiols, and Alkyl Nitrites with Metals • Aminopyridine Iron and Manganese Complexes asMolecular Catalysts for Challenging Oxidative Transformations

Transition Metal Catalysis in Macromolecular Design

Transition Metal Catalysis in Macromolecular Design
Author : Lisa Saunders Boffa,Howard J Schaeffer Distinguished Professor and Head Department of Chemistry Bruce M Novak
Publisher : Amer Chemical Society
Release Date : 2000
Category : Science
Total pages :299
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Metal-mediated polymerization is fast becoming an essential tool for the fine control of macromolecular architecture. Advanced Catalysis demonstrates how the field of transition metal-catalyzed polymer syntheses has moved beyond the simple use of single-site catalysts to new applications and "advanced" techniques of architectural control. This book defines and presents "next generation" techniques and trends for polymer architecture control for an immediate grasp on the future of this exciting field.

Pyridine

Pyridine
Author : Pratima Parashar Pandey
Publisher : BoD – Books on Demand
Release Date : 2018-07-18
Category : Science
Total pages :84
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This book is designed and styled in order to give researchers a vast horizon about pyridine. A deep look in the structural analysis of pyridine provides a base for all the building blocks derived from it and its applications. Pyridines and pyridine moieties are found in many natural products, such as vitamins, coenzymes, alkaloids, many drugs, and pesticides. The book is divided into three parts: the first takes to the introduction, the second part deals with composition of various compounds using heterocyclic ring of pyridine, and the third part discusses about applications of pyridine compounds.