November 28, 2020

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Translational Medicine - What, Why and How: An International Perspective

Translational Medicine - What, Why and How: An International Perspective
Author : B. Alving,K. Dai,S.H.H. Chan
Publisher : Karger Medical and Scientific Publishers
Release Date : 2012-12-21
Category : Medical
Total pages :134
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This book is the first to provide an aerial view, as well as detailed information, on ‘how’ activities in translational medicine are under development in countries such as the USA, China, the UK, and Taiwan. Institutions in each country are training investigators to work as sophisticated interdisciplinary teams. Investigators from 11 US academic health centers explain how they are incentivizing collaborations through pilot project programs, forming partnerships with business schools to promote efficient management of basic and clinical research, creating ethical, high-value public-private (industry) partnerships, improving efficiency with utilization of informatics, and engaging the community in research. The essential role of evaluation is explained in a clear and concise manner. The readers will also learn about the role of private funding in Taiwan and the vision of the government in China in developing multiple translational research centers. The UK is developing methodical approaches to patient needs across their lifespans; ongoing innovation is encouraged through incubator programs. With the emphasis on open innovation and sharing, the concepts and practice of translational medicine are spreading rapidly on an international scale.

Translational Medicine

Translational Medicine
Author : Dennis Cosmatos,Shein-Chung Chow
Publisher : CRC Press
Release Date : 2008-12-17
Category : Mathematics
Total pages :224
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Examines Critical Decisions for Transitioning Lab Science to a Clinical Setting The development of therapeutic pharmaceutical compounds is becoming more expensive, and the success rates for getting such treatments approved for marketing and to the patients is decreasing. As a result, translational medicine (TM) is becoming increasingly important in the healthcare industry – a means of maximizing the consideration and use of information collected as compounds transition from initial lab discovery, through pre-clinical testing, early clinical trials, and late confirmatory studies that lead to regulatory approval of drug release to patients. Translational Medicine: Strategies and Statistical Methods suggests a process for transitioning from the initial lab discovery to the patient’s bedside with minimal disconnect and offers a comprehensive review of statistical design and methodology commonly employed in this bench-to-bedside research. Documents Alternative Research Approaches for Faster and More Accurate Data Judgment Calls Elaborating on how to introduce TM into clinical studies, this authoritative work presents a keen approach to building, executing, and validating statistical models that consider data from various phases of development. It also delineates a truly translational example to help bolster understanding of discussed concepts. This comprehensive guide effectively demonstrates how to overcome obstacles related to successful TM practice. It contains invaluable information for pharmaceutical scientists, research executives, clinicians, and biostatisticians looking to expedite successful implementation of this important process.

Translational Medicine: Tools And Techniques

Translational Medicine: Tools And Techniques
Author : Aamir Shahzad
Publisher : Academic Press
Release Date : 2015-11-24
Category : Medical
Total pages :196
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Translational Medicine: Tools and Techniques provides a standardized path from basic research to the clinic and brings together various policy and practice issues to simplify the broad interdisciplinary field. With discussions from academic and industry leaders at international institutions who have successfully implemented translational medicine techniques and tools in various settings, readers will be guided through implementation strategies relevant to their own needs and institutions. The book also addresses regulatory processes in USA, EU, Japan and China. By providing details on omics sciences techniques, biomarkers, data mining and management approaches, case reports from industry, and tools to assess the value of different technologies and techniques, this book is the first to provide a user-friendly go-to guide for key opinion leaders (KOLs), industry administrators, faculty members, clinicians, researchers, and students interested in translational medicine. Includes detailed and standardized information about the techniques and tools used in translational medicine Provides specific industry case scenarios Explains how to use translational medicine tools and techniques to plan and improve infrastructures and capabilities while reducing cost and optimizing resources

Translational Medicine

Translational Medicine
Author : James Mittra,Christopher-Paul Milne
Publisher : CRC Press
Release Date : 2016-04-19
Category : Medical
Total pages :294
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This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science into viable therapies for the clinic, which includes recognizing the importance of social, commercial, and regulatory environments in addition to good science.

Handbook of translational medicine

Handbook of translational medicine
Author : Josep M. Llovet
Publisher : Edicions Universitat Barcelona
Release Date : 2016-10-05
Category : Medical
Total pages :244
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This handbook aims to capture the basic concepts of translational medicine, understood as a branch of the biomedical field that translates discoveries into the clinical setting. This discipline is currently closing the gap between basic science and clinical research. The book is intended to be straightforward, easy-to-read, intelligible and practical. It describes the basic principles of translational medicine, including major advances in genomics, new technologies, the processing of big data and biobanks. Regarding the biological foundations of translational medicine, we address concepts related to the molecular basis of cancer, inflammation, angiogenesis, stem cells and experimental models. More specifically on translational medicine, we present discoveries and breakthroughs in oncology, neuroscience, metabolic and systemic diseases, and public health. Finally, we have specific sections focused on clinical trials and biomarkers in the genomic era, advances in imaging techniques and entrepreneurship and innovation. Our purpose is to offer a manageable text to guide graduate and post-graduate students, professionals and researchers in biomedicine through the major technologies and advances that have occurred in the translational field. It is also intended to aid residents, fellows and physician-scientists working in hospitals and academic institutions.

Biomaterials in Translational Medicine

Biomaterials in Translational Medicine
Author : Lei Yang,Sarit Bhaduri,Thomas J. Webster
Publisher : Academic Press
Release Date : 2018-11-30
Category : Technology & Engineering
Total pages :358
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Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine Includes the translational or commercialization status of these new biomaterials Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials

Engineering in Translational Medicine

Engineering in Translational Medicine
Author : Weibo Cai
Publisher : Springer Science & Business Media
Release Date : 2013-12-19
Category : Technology & Engineering
Total pages :999
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This book covers a broad area of engineering research in translational medicine. Leaders in academic institutions around the world contributed focused chapters on a broad array of topics such as: cell and tissue engineering (6 chapters), genetic and protein engineering (10 chapters), nanoengineering (10 chapters), biomedical instrumentation (4 chapters), and theranostics and other novel approaches (4 chapters). Each chapter is a stand-alone review that summarizes the state-of-the-art of the specific research area. Engineering in Translational Medicine gives readers a comprehensive and in-depth overview of a broad array of related research areas, making this an excellent reference book for scientists and students both new to engineering/translational medicine and currently working in this area. The ability for engineering approaches to change biomedical research are increasing and having significant impact. Development of basic assays and their numerous applications are allowing for many new discoveries and should eventually impact human health. This book brings together many diverse yet related topics to give the reader a solid overview of many important areas that are not found together elsewhere. Dr. Weibo Cai has taken great care to select key research leaders of many sub-disciplines who have put together very detailed chapters that are easy to read yet highly rich in content. _______________ This book brings together many diverse yet related topics to give the reader a solid overview of many important areas that are not found together elsewhere. Dr. Weibo Cai has taken great care to select key research leaders of many sub-disciplines who have put together very detailed chapters that are easy to read yet highly rich in content. It is very exciting to see such a great set of chapters all together to allow one to have a key understanding of many different areas including cell, gene, protein, and nano engineering as well as the emerging field of theranostics. I am sure the readers will find this collection of important chapters helpful in their own research and understanding of how engineering has and will continue to play a critical role in biomedical research and clinical translation. Sanjiv Sam Gambhir M.D., Ph.D. Stanford University, USA Engineering in Translational Medicine is a landmark book bridging the fields of engineering and medicine with a focus on translational technologies and methods. In a single, well-coordinated volume, this book brings together contributions from a strong and international scientific cast, broadly covering the topics. The book captures the tremendous opportunities made possible by recent developments in bioengineering, and highlights the potential impact of these advances across a broad spectrum of pressing health care needs. The book can equally serve as a text for graduate level courses, a reference source, a book to be dipped into for pleasure by those working within the field, or a cover-to-cover read for those wanting a comprehensive, yet readable introduction to the current state of engineering advances and how they are impacting translational medicine. Simon R. Cherry, Ph.D. University of California, Davis, USA

Dictionary of Stem Cells, Regenerative Medicine, and Translational Medicine

Dictionary of Stem Cells, Regenerative Medicine, and Translational Medicine
Author : Frank J. Dye
Publisher : John Wiley & Sons
Release Date : 2017-02-15
Category : Science
Total pages :376
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Stem cells, regenerative medicine, and translational medicine, are all areas of burgeoning basic research and clinical application. This dictionary includes the fundamental terminology of each of these areas, the major discoveries and significant scientists that comprise the history and current development of the field, as well as a number of concepts. The vocabulary is presented within the broader lexicon of developmental biology and embryology, which provides context for these three fields. Topics covered range from stem cells (embryonic, adult, and iPSCs) to teratology. The inclusion of extensive cross-referencing of the terms will enable readers to broaden their understanding of them. The Dictionary of Stem Cells, Regenerative Medicine, and Translational Medicine will provide both the basic background terminology needed by pre-health professions/biology major undergraduate students and early-stage graduate students, as well as being a valuable reference for university professors, researchers and peers in related disciplines.

Translational Medicine and Drug Discovery

Translational Medicine and Drug Discovery
Author : Bruce H. Littman,Rajesh Krishna
Publisher : Cambridge University Press
Release Date : 2011-01-31
Category : Medical
Total pages :129
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This book, edited by two innovative leaders in the field, focuses on the new discipline of translational medicine as it pertains to drug development within the pharmaceutical and biotechnology industry. Translational medicine seeks to translate biological and molecular knowledge of disease and how drugs work into innovative development strategies that reduce the cost and increase the speed of delivering new medicines for patients. This book outlines general strategies, biomarker development, imaging tools, translational human models and examples of their application to real drug development. The latest thinking is presented by researchers from many of the world's leading drug development companies, including Pfizer, Merck, Eli Lilly, Abbott and Novartis, as well as academic institutions and public-private partnerships that support translational research. This book is essential for anyone interested in translational medicine from a variety of backgrounds: university institutes, medical schools, pharmaceutical companies and drug development researchers and decision-makers.

Carotenoids and Vitamin A in Translational Medicine

Carotenoids and Vitamin A in Translational Medicine
Author : Olaf Sommerburg,Werner Siems,Klaus Kraemer
Publisher : CRC Press
Release Date : 2013-04-24
Category : Medical
Total pages :436
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Vitamin A (retinol) is an essential dietary compound with myriad metabolic and regulatory functions. Deficiency can result in vision problems, compromised immune responses, and a host of other medical issues. More than 600 carotenoids have been identified in plants, algae, fungi, and bacteria, and around 50 carotenoids—including β-carotene—can be converted into vitamin A. Carotenoids and Vitamin A in Translational Medicine reviews the medical use of carotenoids and vitamin A in cancer; diseases of the skin, eye, ear, and lung; and inflammatory bowel and metabolic diseases. It also discusses the analytics of carotenoids and the supply of carotenoids and vitamin A in developing countries. Serving a broad community of researchers and practitioners conducting basic and clinical analysis on carotenoids and vitamin A for medical purposes, the book evaluates basic research, epidemiological studies, and clinical trials in the field. It updates information on the worldwide problem of vitamin A deficiency and discusses extensively the pros and cons of carotenoid supplementation in cancer. The authors provide a comprehensive overview of the efforts made in the field of carotenoid research with respect to translational medicine and present the future outlook on carotenoids as new therapeutic agents. It is the editors’ intent through the contributions in this volume to expand this important discussion on therapeutic approaches using carotenoids and retinoids. In doing so, they hope to enhance the quality of research which brings safe, effective, and clinically proven medicines to patients.

Technology and Method Developments for High-throughput Translational Medicine

Technology and Method Developments for High-throughput Translational Medicine
Author : Anonim
Publisher : Stanford University
Release Date : 2011
Category :
Total pages :129
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Translation of knowledge from basic science to medicine is essential to improving both clinical research and practice. In this translation, high-throughput genomic approaches can greatly accelerate our understanding of molecular mechanisms of diseases. A successful high-throughput genomic study of disease requires, first, comprehensive and efficient platforms to collect genomic data from clinical samples, and second, computational analysis methods that utilize databases of prior biological knowledge together with experimental data to derive clinically meaningful results. In this thesis, we discuss the development of a new microarray platform as well as computational methods for knowledge-based analysis along with their applications in clinical research. First, we and other colleagues have developed a new high-density oligonucleo-tide array of the human transcriptome for high-throughput and cost-efficient analysis of patient samples in clinical studies. This array allows comprehensive examination of gene expression and genome-wide identification of alternative splicing, and also pro-vides assays for coding SNP detection and non-coding transcripts. Compared with high-throughput mRNA sequencing technology, we show that this array is highly re-producible in estimating gene and exon expression, and sensitive in detecting expres-sion changes. In addition, the exon-exon junction feature of this array is shown to im-prove detection efficiency for mRNA alternative splicing when combined with an ap-propriate computational method. We implemented the use of this array in a multi-center clinical program and have obtained comparable levels of high quality and re-producible data. With low costs and high throughputs for sample processing, we antic-ipate that this array platform will have a wide range of applications in high-throughput clinical studies. Second, we investigated knowledge-based methods that utilize prior know-ledge from biology and medicine to improve analysis and interpretation of high-throughput genomic data. We have developed knowledge-based methods to enrich our prior knowledge, illustrate dynamic response to external stimulus, and identify distur-bances in cellular pathways by chemical exposure, as well as discover hidden biological signatures for the prediction of patient outcomes. Finally, we applied a knowledge-based approach in a large scale genomic study of trauma patients. Cooperating with clinical information, prior knowledge improved the interpretation of common and dif-ferential genomic response to injury, and provided efficient risk assessment for patient outcomes. The clinical and genomic data as well as analysis results in this trauma study were systematically organized and provided to research communities as new knowledge of traumatic injury. The microarray platform and knowledge-based methods presented in this thesis provide appropriate research tools for high-throughput translational medicine in a large clinical setting. This thesis is expected to advance understanding and treatment for dis-eases, and finally, improve public health.

Principles of Translational Science in Medicine

Principles of Translational Science in Medicine
Author : Martin Wehling
Publisher : Academic Press
Release Date : 2015-04-02
Category : Science
Total pages :364
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Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

Translational Medicine

Translational Medicine
Author : Robert A. Meyers
Publisher : John Wiley & Sons
Release Date : 2018-07-16
Category : Science
Total pages :1064
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This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.

Cell Biology and Translational Medicine, Volume 9

Cell Biology and Translational Medicine, Volume 9
Author : Kursad Turksen
Publisher : Springer Nature
Release Date : 2020
Category :
Total pages :129
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Cell Biology and Translational Medicine, Volume 10

Cell Biology and Translational Medicine, Volume 10
Author : Kursad Turksen (Retired)
Publisher : Springer Nature
Release Date : 2020
Category :
Total pages :129
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