June 18, 2021

Download Ebook Free Unraveling The Complexities Of Metastasis

Unraveling the Complexities of Metastasis

Unraveling the Complexities of Metastasis
Author : Ammad Ahmad Farooqi,Muhammad Zahid Qureshi,Uteuliyev Yerzhan Sabitaliyevi
Publisher : Academic Press
Release Date : 2020-09-15
Category :
Total pages :200
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Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer. The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism. This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis. Explains the mechanism of metastasis from basic to advanced level through easy and comprehensive chapters written by internationally distinguished researchers Provides simplified version of important process of metastasis for the readers to comprehend the latest advancements made in the field Presents colorful diagrams to make different aspects of scientifically difficult topics easier for young researchers and new-comers in the field of cancer metastasis

The Role of Eukaryotic Initiation Factor 4E (eIF4E) in Osteosarcoma Metastasis

The Role of Eukaryotic Initiation Factor 4E (eIF4E) in Osteosarcoma Metastasis
Author : Tanasa S. Osborne
Publisher : Unknown
Release Date : 2011
Category :
Total pages :129
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The most significant problem for cancer patients is the dissemination of cancer cells and the formation of metastatic disease. Emblematic of the problem is the clinical progression seen in most patients with osteosarcoma, where metastasis to the lung is the most common cause of death. The primary research need in the field is to understand the biology of metastasis in osteosarcoma so as to improve outcomes for future patients. Unraveling the complexity of metastasis demands a focus on new tools, reagents, and biology in order to investigate hypotheses. Accordingly, this body of work introduces an outcome-linked human ostoesarcoma tissue microarray (new tool) used to detect and validate protein biomarkers across a variety of patients and an ex vivo pulmonary metastasis assay (new reagent) that allows real-time assessment of metastatic progression in a relevant microenvironment. Furthermore, cancer cells are believed to efficiently regulate protein translation at specific times and locations in a cell in response to changes in their environment. Preventing the dynamic regulation of these proteins (many of which have been associated with cancer/metastasis) may be an effective treatment strategy in the management of metastasis. Within the process of protein translation the abundance and activation of the mRNA cap-binding phosphoprotein, eukaryotic initiation factor 4E (eIF4E) is considered to be both rate and process limiting. We describe for the first time, the biological role of eIF4E (new biology) in metastatic osteosarcoma. We employed a comparative approach to study the biology of metastasis in osteosarcoma by using tissues and reagents from murine and human osteosarcomas. Using overexpression and knockdown techniques we modulated eIF4E expression in murine and human osteosarcoma cell lines and then evaluated the consequences at various steps within the metastatic cascade in vitro and in vivo. We found that suppression of eIF4E significantly delayed migration and reduced the number and size of colonies that formed in soft agar. Additionally, suppression of eIF4E inhibited spontaneous pulmonary metastases. eIF4E overexpression did not change the phenotype of previously nonmetastatic cells. These results suggest eIF4E may be a necessary, but not sufficient, requirement for metastasis in osteosarcoma. The goals of this research were to utilize these new tools and reagents to identify proteins and/or processes that define the metastatic phenotype of osteosarcoma and to use our newfound understanding of eIF4E in osteosarcoma metastasis to develop novel therapeutic strategies to prevent growth of metastases and improve treatment outcomes for patients.

Molecular and Cellular Basis of Metastasis: Road to Therapy

Molecular and Cellular Basis of Metastasis: Road to Therapy
Author : Anonim
Publisher : Academic Press
Release Date : 2016-09-03
Category : Medical
Total pages :390
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Molecular and Cellular Basis of Metastasis: Road to Therapy, the latest in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, with this volume covering the molecular and cellular basis of metastasis. Presents groundbreaking information on the molecular and cellular basis of metastasis Provides information on cancer research Outstanding and original reviews Suitable for both researchers and students

ICRDB Cancergram

ICRDB Cancergram
Author : Anonim
Publisher : Unknown
Release Date : 1986
Category : Carcinogenesis
Total pages :129
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Metastasis Research Protocols

Metastasis Research Protocols
Author : Susan A. Brooks,Udo Schumacher
Publisher : Humana Press
Release Date : 2010-11-09
Category : Medical
Total pages :344
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The process of metastasis formation is hugely complex, as described in the introductory chapter of this book, and this complexity has led us to compile two volumes of methods, from a vastly divergent background that attempts to encompass the whole spectrum of cancer biology. This first volume, Metastasis Research Protocols: Analysis of Cells and Tissues, concentrates on analysis and mapping of molecules produced by cells and tissues and analysis of the molecular biology underlying their expression, whereas the second volume, Metastasis Research Protocols: Cell Behavior In Vitro and In Vivo,focuses sharply on the determination of cell behavior in vitro and in vivo. We have deliberately included chapters describing well-established and familiar te- niques (for example, SDS-PAGE and Western blotting [Chapter 11], and immunocytochemistry [Chapter 2]) in addition to the newer and more speci- ized approaches and specific examples of their application, because—although the methodology is readily available in the published literature and established in many laboratories—we wished these volumes to “stand alone” and to make accessible here the standard techniques that underpin much metastasis research for both the newcomer to the field and the seasoned researcher. Undoubtedly, owing to the complexity of the metastatic cascade and the wealth of research techniques involved in scientific approaches to its unraveling, and despite our best efforts to make these volumes as comprehensive as seems feasible, this is a tall order, and there will inevitably be omissions. For these we apologize.

Genomic Instability and Cancer Metastasis

Genomic Instability and Cancer Metastasis
Author : Chris Maxwell,Cal Roskelley
Publisher : Springer
Release Date : 2014-12-04
Category : Medical
Total pages :247
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Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse. This book connects cancer metastasis with genomic instability in a comprehensive manner. Section 1 outlines the fundamental mechanisms responsible for these cellular and tissue phenotypes. Section 2 discusses in silico, in vitro, and in vivo models used for the experimental study of these processes. Section 3 reviews emerging themes (ex., microenvironment, mechanotransduction, and immunomodulation), and Section 4 highlights new therapeutic approaches to overcome the unique challenges presented by the heterogeneous and metastatic tumor. This book is intended for undergraduates and postgraduates with an interest in the areas of medicine, oncology, and cancer biology as well as for the content expert searching for thorough reviews of current knowledge in these areas.

Metastasis Research Protocols

Metastasis Research Protocols
Author : Susan A. Brooks,Udo Schumacher
Publisher : Springer Science & Business Media
Release Date : 2001
Category : Cancer cells
Total pages :344
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Although ninety percent of fatal cancer cases involve the spread of a primary tumor, the formation of metastases is still a poorly understood, complex process and a significant problem in the treatment of cancer patients. In Metastasis Research Protocols, leading international investigators describe the key methods needed to investigate why and how metastasis occurs. Volume I of this two-volume set, Analysis of Cells and Tissues, presents a comprehensive collection of established and leading-edge techniques for analyzing the expression of key molecules and for examining their production at the genetic level. The work focuses on the analysis and mapping of molecules produced by cells and tissues, and on the molecular biology underlying their expression. The traditional methods range from the histopathological and the immunocytochemical to SDS-PAGE, Western blotting, and enzyme zymography. Newer and more specialized techniques for analyzing the genetic aspects of metastasis include in situ hybridization to localize mRNAs, FISH, CGH, methylation analysis of CpG islands, RT-PCR, and differential display. The second volume of this set, Analysis of Cell Behavior In Vitro and In Vivo, moves to the level of living cells and tissues to present methodologies applicable to examining metastatic behavior in vitro and in the whole animal. Comprehensive and authoritative, the two volumes of Metastasis Research Protocols constitute a gold-standard collection of readily reproducible methods for understanding the metastatic cascade-first at the cellular and molecular levels, then at the level of the whole organism-responsible for the spread of cancer and for developing novel strategies to combat its spread.

Metastasis

Metastasis
Author : Lalage Wakefield,Kent W. Hunter
Publisher : IOS Press
Release Date : 2007
Category : Medical
Total pages :162
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"Metastasis is the most dreaded aspect of the carcinogenic process. More than ninety percent of all cancer deaths are attributable to the consequences of the primary tumor successfully colonizing distant organs. Unlike the situation with colon cancer, a patient with breast cancer can never be considered cured, since as many as a third of breast cancer patients who have apparently curative surgery for their primary tumors ultimately relapse with metastatic disease, sometimes decades later. Much effort is now devoted to understanding this process of metastasis, and finding ways to predict and prevent its occurrence. This publication covers recent advances in the field, specifically as they relate to breast cancer. The availability of new tools and technological approaches has prompted a reconsideration of the very definition of a metastasis. Furthermore, a number of commonly held myths are being explored and a new definition of a metastasis, with important implications for clinical staging, is being proposed. Also, a novel conceptual framework for cancer progression based on the system-level dynamics of regulatory networks is presented and the role of chemokines in mediating some of the evolving transactional processes between tumor and stroma is being reviewed."

Regenerative Medicine Technology

Regenerative Medicine Technology
Author : Sean V. Murphy,Anthony Atala
Publisher : CRC Press
Release Date : 2016-11-30
Category : Medical
Total pages :428
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Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery. This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.

Cancer Research

Cancer Research
Author : Anonim
Publisher : Unknown
Release Date : 2009-08
Category : Cancer
Total pages :129
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Pain

Pain
Author : Anonim
Publisher : Unknown
Release Date : 1985
Category : Pain
Total pages :128
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Scientific Report

Scientific Report
Author : Scripps Research Institute
Publisher : Unknown
Release Date : 2000
Category : Medicine
Total pages :129
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Assessing the Role of Sumoylation in Genotoxic Stress Induced NF-kappaB Activation

Assessing the Role of Sumoylation in Genotoxic Stress Induced NF-kappaB Activation
Author : Angela M. Mabb
Publisher : Unknown
Release Date : 2007
Category :
Total pages :212
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Journal of Cellular Physiology

Journal of Cellular Physiology
Author : Anonim
Publisher : Unknown
Release Date : 1984
Category : Cancer
Total pages :214
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Scientific Foundations of Surgery

Scientific Foundations of Surgery
Author : James Kyle,Larry C. Carey
Publisher : Unknown
Release Date : 1989
Category : Pathologie chirurgicale
Total pages :651
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